Administrative Core

抽象行政核心 杜克大学/北卡罗来纳大学阿尔茨海默病研究中心(ADRC)行政核心提供领导， 为杜克大学/北卡罗来纳大学ADRC的五个核心(临床；神经病理学； 数据管理和统计(DMS)；外联、征聘和参与(ORE)；以及生物标记员 核心)及其研究教育部分(REC)。行政核心负责培育 并围绕确定与年龄相关的变化这一主题来促进“中心性”， 有助于阿尔茨海默病(AD)的发展、进展和经验。虽然我们的主题和 队列研究侧重于AD，管理核心确保Duke/UNC ADRC满足需求 研究AD或阿尔茨海默病相关痴呆的任何方面的更广泛的研究社区 (AD ADRD)。为此，行政核心每年进行需求评估，提供“礼宾”。 为有兴趣利用亚洲发展研究中心的专业知识和资源的本地或非本地调查人员提供服务，监督 及时、合规地共享数据和资源并管理开发项目的过程 刺激和支持AD ADRD研究的创新路线的计划。确保定期评估 核心和区域经济共同体的有效性和可及性，以及正式的年度评价和随后对 杜克大学/北卡罗来纳大学ADRC，行政核心监测所有核心/REC的进展并聘请内部咨询 由机构领导人和AD ADRD顶尖科学家组成的委员会(IAC)和外部顾问委员会(EAB) 科学界和非科学界的成员。行政核心的具体目标是：1)还提供协调 作为科学和行政领导和监督，以确保业务效率、财政责任、 和法规遵从性；2)支持和颁布严格的AD ADRD研究文化；3)征集， 从各种高素质、有创意的人才池中选择、管理和监控开发项目(DP) 调查人员；4)维持和促进杜克大学/北卡罗来纳大学发展研究中心与外部利益攸关方之间的联系；5) 通过年度评估过程评估和完善杜克大学/北卡罗来纳大学ADRC计划。美国政府的关键作用 这个新的ADRC的行政核心将是领导识别、培育和评估“口袋”的过程 机会“，着眼于如何开发和运作这些领域，可能作为新的领域 随着中心的发展，核心研究或辅助研究。

ABSTRACT - ADMINISTRATIVE CORE The Duke/UNC Alzheimer’s Disease Research Center (ADRC) Administrative Core provides leadership, oversight, and infrastructure support for each of the Duke/UNC ADRC’s five Cores (Clinical; Neuropathology; Data Management and Statistical (DMS); Outreach, Recruitment, and Engagement (ORE); and Biomarker Cores) and its Research Education Component (REC). The Administrative Core is responsible for cultivating and promoting “Center-ness” around the theme of identifying age-related changes across the lifespan that contribute to the development, progression, and experience of Alzheimer’s disease (AD). While our theme and cohort studies are focused on AD, the Administrative Core ensures that the Duke/UNC ADRC meets the needs of a broader community of researchers studying any aspect of AD or Alzheimer’s disease-related dementias (AD+ADRD). To this end, the Administrative Core conducts annual needs assessments, provides a “concierge service” for local or non-local investigators interested in accessing ADRC expertise and resources, oversees the process of timely and compliant sharing of data and resources, and administers a Developmental Project program to stimulate and support innovative lines of AD+ADRD research. To ensure regular assessment of the Cores’ and REC’s effectiveness and accessibility, and formal annual evaluation and subsequent response of the Duke/UNC ADRC, the Administrative Core monitors progress of all Cores/REC and engages an Internal Advisory Committee (IAC) of institutional leaders and leading AD+ADRD scientists and an External Advisory Board (EAB) of both scientific and lay members. The Administrative Core Specific Aims are to: 1) Provide coordination as well as scientific and administrative leadership and oversight to ensure operational efficiency, fiscal responsibility, and regulatory compliance; 2) Support and promulgate a culture of rigorous AD+ADRD research; 3) Solicit, select, administer, and monitor developmental projects (DP), from a diverse pool of high-caliber, creative investigators; 4) Sustain and promote connection between the Duke/UNC ADRC and external stakeholders; 5) Assess and refine the Duke/UNC ADRC program through an annual evaluation process. A critical role of the Administrative Core in this new ADRC will be to lead the process of identifying, nurturing, and evaluating “pockets of opportunity” with an eye toward how such areas should be developed and operationalized, possibly as new Cores or ancillary studies, as the Center evolves.