Administrative Core

摘要-行政核心 杜克/杜克阿尔茨海默病研究中心（ADRC）行政核心提供领导， 监督和基础设施支持杜克/杜克大学ADRC的五个核心（临床;神经病理学; 数据管理和统计（DMS）;外展，招募和参与（ORE）;和生物标志物 核心）及其研究教育组件（REC）。行政核心负责培养 并围绕确定整个生命周期中与年龄有关的变化这一主题促进“中心性”， 有助于阿尔茨海默病（AD）的发展，进展和经历。虽然我们的主题和 队列研究的重点是AD，行政核心确保杜克/杜克大学ADRC满足需求 研究AD或阿尔茨海默病相关痴呆症任何方面的更广泛的研究人员社区 (AD+ADRD）。为此，行政核心每年进行需求评估，提供“礼宾服务”， 为有兴趣获得ADRC专业知识和资源的当地或非当地调查人员提供“服务”，监督 及时、合规地共享数据和资源的过程，并管理一个发展项目 该计划旨在激励和支持AD+ADRD研究的创新路线。确保定期评估 核心文件和区域经济合作委员会的有效性和可获得性， 行政核心杜克/杜克大学ADRC监测所有核心/REC的进展，并聘请内部顾问 由机构领导人和主要AD+ADRD科学家组成的委员会（IAC）和外部咨询委员会（EAB） 科学家和外行人的参与。行政核心的具体目标是：1）提供协调，以及 作为科学和行政领导和监督，以确保运作效率，财政责任， 和法规遵从性; 2）支持和宣传严格的AD+ADRD研究文化; 3）征求， 选择，管理和监督发展项目（DP），从一个高素质的，创造性的，多样化的人才库， 调查员; 4）维持和促进杜克/杜克大学ADRC与外部利益相关者之间的联系; 5） 通过年度评估过程评估和完善杜克/杜克大学ADRC计划。一个关键的作用， 这个新的ADRC的行政核心将领导识别、培育和评估“口袋”的过程 的机会”，着眼于这些领域应该如何发展和运作，可能作为新的 核心或辅助研究，随着中心的发展。

ABSTRACT - ADMINISTRATIVE CORE The Duke/UNC Alzheimer’s Disease Research Center (ADRC) Administrative Core provides leadership, oversight, and infrastructure support for each of the Duke/UNC ADRC’s five Cores (Clinical; Neuropathology; Data Management and Statistical (DMS); Outreach, Recruitment, and Engagement (ORE); and Biomarker Cores) and its Research Education Component (REC). The Administrative Core is responsible for cultivating and promoting “Center-ness” around the theme of identifying age-related changes across the lifespan that contribute to the development, progression, and experience of Alzheimer’s disease (AD). While our theme and cohort studies are focused on AD, the Administrative Core ensures that the Duke/UNC ADRC meets the needs of a broader community of researchers studying any aspect of AD or Alzheimer’s disease-related dementias (AD+ADRD). To this end, the Administrative Core conducts annual needs assessments, provides a “concierge service” for local or non-local investigators interested in accessing ADRC expertise and resources, oversees the process of timely and compliant sharing of data and resources, and administers a Developmental Project program to stimulate and support innovative lines of AD+ADRD research. To ensure regular assessment of the Cores’ and REC’s effectiveness and accessibility, and formal annual evaluation and subsequent response of the Duke/UNC ADRC, the Administrative Core monitors progress of all Cores/REC and engages an Internal Advisory Committee (IAC) of institutional leaders and leading AD+ADRD scientists and an External Advisory Board (EAB) of both scientific and lay members. The Administrative Core Specific Aims are to: 1) Provide coordination as well as scientific and administrative leadership and oversight to ensure operational efficiency, fiscal responsibility, and regulatory compliance; 2) Support and promulgate a culture of rigorous AD+ADRD research; 3) Solicit, select, administer, and monitor developmental projects (DP), from a diverse pool of high-caliber, creative investigators; 4) Sustain and promote connection between the Duke/UNC ADRC and external stakeholders; 5) Assess and refine the Duke/UNC ADRC program through an annual evaluation process. A critical role of the Administrative Core in this new ADRC will be to lead the process of identifying, nurturing, and evaluating “pockets of opportunity” with an eye toward how such areas should be developed and operationalized, possibly as new Cores or ancillary studies, as the Center evolves.