Geriatrics Research: From Bench to Bedside

老年病学研究：从实验室到临床

• 批准号: 9291407
• 负责人: Heather E. Whitson
• 金额: $ 5.99万
• 依托单位: AMERICAN GERIATRICS SOCIETY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9291407
• 关键词: Address; Adherence; Age; Aging; American; Applications Grants; Area; Award; Baltimore; Cardiovascular Diseases; Caregiver Burden; Caring; Chronic; Chronic Disease; Clinical; Cognition; Collaborations; Communities; Comorbidity; Complex; Delirium; Development; Discipline; Disease; Elderly; Ensure; Evaluation; Evidence based treatment; Faculty; Fatigue; Fatty acid glycerol esters; Feedback; Feeling; Fostering; Foundations; Funding; Future; Geriatrics; Gerontology; Geroscience; Glossary; Goals; Grant; Growth; Guidelines; Health; Heterogeneity; Impaired cognition; Impairment; Industry; Inflammation; Institutes; Interdisciplinary Study; Intervention; Journals; Knowledge; Letters; Link; Location; Malignant Neoplasms; Medical; Mentors; Minority Participation; Mission; Modeling; Morbidity - disease rate; Muscle; National Institute on Aging; Obesity; Osteoporosis; Outcome; Participant; Persons; Philadelphia; Physical activity; Physiological; Population; Prevention; Program Development; Psyche structure; Publications; Quality of life; Recommendation; Research; Research Personnel; Risk Factors; Scientific Advances and Accomplishments; Scientist; Sensory; Series; Sleep Disorders; Slide; Societies; Soft Tissue Disorder; Structure; Testing; Thinking; Time; TimeLine; Training; Translating; Translational Research; Travel; United States National Institutes of Health; Urinary Incontinence; age related; base; bench to bedside; career development; clinical care; clinically relevant; comparative effectiveness; effective therapy; effectiveness research; experience; falls; frailty; improved; insight; medical specialties; meetings; multidisciplinary; multiple chronic conditions; novel; nutrient metabolism; programs; sarcopenia; soft tissue; symposium; tool; translational scientist; webinar

Project Abstract This U13 conference grant application titled “Geriatrics Research: From Bench to Bedside” is a competing renewal submitted on behalf of the American Geriatrics Society (AGS) and the Geriatrics and Clinical Gerontology Branch of the National Institute on Aging (NIA). The AGS/NIA “Bench to Bedside” series, now in its 10th year, has been highly successful (see Letters of Support and Background). The overall objective of the series is to advance research on emerging geriatrics topics with potential to greatly improve clinical care or prevention for older adults. Here, we propose three conferences, each focused on a common and clinically important pair of age-related conditions. The conferences will probe basic, clinical, and translational questions relevant to reducing co-occurrence and improving health outcomes for seniors with each dyad. As the population ages, the number of Americans with multiple chronic conditions, or multimorbidity, continues to grow. Although the majority of seniors have multimorbidity, we lack an evidence base for treatments and tools that have been tested in this rapidly increasing segment of the population. We have limited understanding of shared physiological mechanisms that underlie or link age-related conditions. There is a pressing need to advance scientific knowledge and comparative effectiveness research that will improve care practices and health outcomes for people with multimorbidity. Yet multimorbidity is a heterogeneous issue, which can hinder efforts to advance an actionable research agenda. The proposed series will create an opportunity to deepen meaningful collaborations and identify and prioritize specific knowledge and need gaps by focusing on the interface between three carefully selected pairs of conditions. The proposed topics for the conference series are: 1) sensory impairment & cognitive decline, 2) osteoporosis & soft tissue (muscle/fat) disorders, and 3) cancer & cardiovascular disease. The Specific Aims are: 1) Hold three multidisciplinary conferences that will define knowledge gaps and future priorities in aging research, 2) Foster dialogue in a manner that advances high quality research and new collaboration, and 3) Foster the growth of a diverse and productive research workforce that is trained and committed to addressing these problems. Key features of each conference will be: networking across disciplines, institutes, and stakeholders; strategies to encourage participation from under-represented groups; a career development program for Rising Stars; mechanisms to ensure timely dissemination, support emerging collaborations, and sustain momentum. Our plans benefit from the organizers’ experience, prior evaluations, and lessons learned over the past decade. Additionally, feedback from participants at initial meetings will help fine-tune the program and structure of subsequent meetings. The conference series is led by an Oversight Board. A Planning Committee for each conference includes experts in relevant fields, NIA representation, and at least one junior investigator; the Planning Committee is responsible for content and delivery of the meeting, post-meeting activities, and dissemination of findings.

项目摘要 这个U13会议资助申请题为“老年医学研究：从板凳到床边”是一个竞争 代表美国老年医学会（AGS）以及老年医学和临床医学会提交的更新 国家老龄问题研究所老年学分支。AGS/NIA“从工作台到床边”系列，现在在 成立10周年，取得了巨大成功（请参阅支持信和背景）。的总体目标 该系列旨在推进对新兴老年医学主题的研究，这些主题有可能大大改善临床护理或 预防老年人。在这里，我们提出了三个会议，每一个集中在一个共同的和临床上 与年龄有关的两个重要条件。会议将探讨基础，临床和翻译 与减少并发症和改善老年人健康结果有关的问题。 随着人口老龄化，患有多种慢性病或多发病的美国人的数量， 一个继续增长虽然大多数老年人患有多发性硬化症，但我们缺乏证据基础， 治疗方法和工具已经在这个快速增长的人群中进行了测试。我们有 对年龄相关疾病的共同生理机制的理解有限。有 迫切需要推进科学知识和比较有效性研究，以改善护理 实践和健康结果的人与多morphine。然而，多重死亡是一个复杂的问题， 这可能会阻碍推进可操作的研究议程的努力。该系列将创建一个 有机会深化有意义的合作，确定具体的知识和需求差距并将其列为优先事项 通过关注三个精心选择的条件对之间的界面。会议的拟议议题 会议系列是：1）感觉障碍和认知能力下降，2）骨质疏松症和软组织（肌肉/脂肪） 疾病，和3）癌症和心血管疾病。具体目标是：1）举办三个多学科 会议，将确定知识差距和未来的优先事项，在老龄化研究，2）促进对话， 促进高质量研究和新合作的方式，以及3）促进多样化和 生产力的研究队伍是训练有素的，并致力于解决这些问题。的关键特征 每次会议将：跨学科，机构和利益相关者的网络;鼓励战略 代表性不足的群体的参与;新星的职业发展计划; 确保及时传播，支持新出现的合作，并保持势头。我们的计划得益于 组织者的经验、先前的评估和过去十年的经验教训。此外，反馈 初步会议与会者的意见将有助于调整后续会议的方案和结构。的 会议系列由监督委员会领导。每次会议的规划委员会包括下列专家： 相关领域，NIA代表和至少一名初级调查员;规划委员会负责 会议的内容和交付、会后活动和传播调查结果。