HU-CHEM: Deploying evidence-based interventions in Chemistry at Hampton University to plug leaks in the biomedical training pipeline

HU-CHEM：在汉普顿大学化学领域部署循证干预措施，以堵住生物医学培训渠道中的漏洞

• 批准号: 10475730
• 负责人: OLUWATOYIN Ajibola ASOJO
• 金额: $ 37.5万
• 依托单位: HAMPTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475730
• 关键词: Academy; Active Learning; Administrator; Award; Biomedical Research; Case-Control Studies; Chemistry; Collaborations; Competence; Consent; Control Groups; Data; Data Analyses; Education; Educational process of instructing; Evidence based intervention; Faculty; Gatekeeping; Historically Black Colleges and Universities; Immersion; Intervention; Measures; Mentorship; Mission; Monitor; NCI Scholars Program; Outcome; Outcome Measure; Participant; Research; Research Design; Risk; STEM field; Schools; Science; Self Efficacy; Statistical Data Interpretation; Student Persistence; Students; Surveys; Teacher Professional Development; Testing; Texas; Time; Training; Translations; Universities; Vision; base; career; cohort; college; cost effective; educational atmosphere; efficacy testing; evidence base; experience; feasibility testing; follow-up; improved; innovation; interest; intervention program; pedagogy; programs; recruit; success; tool; undergraduate research experience; underrepresented minority student; university student

Project Summary We are submitting a Diversity Program Consortium (DPC) Dissemination and Translation Awards proposal to deploy and test evidence-based interventions to increase diversity in biomedical careers. Our proposal is to deploy the Hampton University Chemistry Education and Mentorship (HU-ChEM) intervention program to increase the persistence of underrepresented minority students in biomedical careers at Hampton University, a Historically Black Colleges and University (HBCU). Using a matched baseline control study design, we will test the efficacy of innovative, evidence-based interventions to improve student competency in gatekeeper chemistry courses at Hampton University, transform the departmental culture and improve the persistence of Hampton University students into biomedical careers. Our justification is that freshman chemistry is a gatekeeper course that leads to attrition and leaks in the biomedical training pipeline. HU-ChEM will include 3 interventions: 1) HU-ChEM SCALE-UP in which the entry level freshman chemistry course for STEM majors is taught using the Student-Centered Active Learning Environment with Upside-down Pedagogies (SCALE-UP); 2) HU-ChEM CUREs in which a pre-college Course-based Undergraduate Research Experiences (CUREs) academy is deployed; and 3) HU-ChEM faculty development, that offers enhanced training of chemistry faculty. We will conduct our interventions over the 3-year duration of this study and use DPC survey tools to measure and monitor the DPC hallmarks of student, faculty, and institutional success. We will collect both quantitative, and qualitative data and use robust statistical analysis to measure the effects of HU-ChEM interventions on participants compared to matched controls in the short-, medium- and long- terms. All cohort participants will be consented, and we will collect outcomes data for the 3-year duration of the project. We will also follow-up on participants and matched controls for 15 years in order to ascertain medium- and long- term outcomes and measures of success. Analysis of data from generated from HU-ChEM will reveal cost-effective ways of deploying intervention programs to plug the leaky biomedical training pipeline. HU-ChEM is a collaboration of educators, administrators, subject matter experts, students, alumni, and faculty to close the leaky training pipeline and increase diversity in biomedical careers. We are collaborating with the University of Texas, El Paso: BUILDing SCHOLARS program, to gain from their expertise in faculty training, deploying interventions, and to compare outcomes data.

项目摘要 我们正在提交多样性计划联盟(DPC)传播和翻译奖提案，以 部署和测试基于证据的干预措施，以增加生物医学职业的多样性。我们的建议是 部署汉普顿大学化学教育和导师(HU-CHEM)干预计划以 提高未被充分代表的少数族裔学生在汉普顿大学生物医学职业生涯中的持久性 历史上的黑人学院和大学(HBCU)。使用匹配的基线对照研究设计，我们将测试 创新的循证干预对提高学生看门人能力的有效性 汉普顿大学化学课程，转变系文化，提高坚持不懈 汉普顿大学的学生进入了生物医学职业生涯。我们的理由是，一年级的化学是一门 看门人课程，导致生物医学培训管道中的自然减员和泄漏。Huu-Chem将包括3个 干预：1)HU-CHEM扩大规模，STEM专业一年级化学课程的入门水平为 使用以学生为中心的主动学习环境进行教学，采用倒置教学法(按比例向上扩展)； 2)以大学预科课程为基础的本科生研究经验(CURES) 部署了学院；以及3)胡化学教师发展，提供加强的化学培训 教职员工。我们将在本研究的3年期间进行干预，并使用DPC调查工具 衡量和监控学生、教师和机构成功的DPC标志。我们会把两者都收集起来 定量和定性的数据，并使用稳健的统计分析来衡量沪化的效果 在短期、中期和长期内对参与者进行干预，并与匹配的对照组进行比较。所有队列 参与者将获得同意，我们将收集项目3年持续时间的结果数据。我们会 还对参与者和配对对照进行了15年的跟踪调查，以确定中长期 成果和成功的衡量标准。对从HU-CHEM产生的数据的分析将揭示成本效益 部署干预计划以堵塞漏水的生物医学培训管道的方法。胡哲是一位 教育工作者、管理人员、主题专家、学生、校友和教职员工之间的协作，以结束 漏水的培训渠道和增加生物医学职业的多样性。我们正在与加州大学合作 德克萨斯州，埃尔帕索：建立学者计划，以利用他们在教师培训方面的专业知识，部署 干预措施，并比较结果数据。

项目成果

Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis.

• DOI: 10.1107/s2053230x21013078
• 发表时间: 2022-01-01
• 期刊: Acta crystallographica. Section F, Structural biology communications
• 作者: Porter I;Neal T;Walker Z;Hayes D;Fowler K;Billups N;Rhoades A;Smith C;Smith K;Staker BL;Dranow DM;Mayclin SJ;Subramanian S;Edwards TE;Myler PJ;Asojo OA
• 通讯作者: Asojo OA

Crystal structure of a short-chain dehydrogenase/reductase from Burkholderia phymatum in complex with NAD.

• DOI: 10.1107/s2053230x22000218
• 发表时间: 2022-02-01
• 期刊: Acta crystallographica. Section F, Structural biology communications
• 作者: Alenazi J;Mayclin S;Subramanian S;Myler PJ;Asojo OA
• 通讯作者: Asojo OA

Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans.

• DOI: 10.1107/s2053230x21012632
• 发表时间: 2022-01-01
• 期刊: Acta crystallographica. Section F, Structural biology communications
• 作者: Davidson J;Nicholas K;Young J;Conrady DG;Mayclin S;Subramanian S;Staker BL;Myler PJ;Asojo OA
• 通讯作者: Asojo OA

Prostate secretory protein 94 inhibits sterol binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner.

前列腺分泌蛋白 94 以钙敏感方式抑制哺乳动物 CAP 蛋白 CRISP2 的甾醇结合和输出。

• DOI: 10.1016/j.jbc.2022.101600
• 发表时间: 2022-03
• 期刊: The Journal of biological chemistry
• 作者: El Atab O;Kocabey AE;Asojo OA;Schneiter R
• 通讯作者: Schneiter R

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx.

来自沙眼衣原体D/UW-3/CX的无机焦磷酸酶的晶体结构。

• DOI: 10.1107/s2053230x22002138
• 发表时间: 2022-03-01
• 期刊: Acta crystallographica. Section F, Structural biology communications
• 作者: Maddy J;Staker BL;Subramanian S;Abendroth J;Edwards TE;Myler PJ;Hybiske K;Asojo OA
• 通讯作者: Asojo OA