Neurobiological and psychobiological signatures of vocal effort in early career teachers

早期职业教师发声努力的神经生物学和心理生物学特征

• 批准号: 10475746
• 负责人: MARIA DIETRICH
• 金额: $ 44.87万
• 依托单位: UNIVERSITY HOSPITAL BONN
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475746
• 关键词: Acoustics; Address; Age; Algorithms; Amygdaloid structure; Anterior; Aphonia; Area; Behavioral; Behavioral inhibition; Brain; Case Study; Classification; Clinical; Conversion disorder; Cues; Data; Data Collection; Dysphonia; Educational process of instructing; Electrodes; Electromyography; Event; Exposure to; Fatigue; Female; Functional Magnetic Resonance Imaging; Functional disorder; Future Teacher; Goals; Hydrocortisone; Individual; Individual Differences; Intervention; Introversion; Knowledge; Laryngeal muscle structure; Larynx; Magnetic Resonance Imaging; Manuals; Meditation; Motor; Motor Cortex; Muscle; Muscle Tension; Neck; Neurobiology; Participant; Pathway interactions; Patient Self-Report; Patients; Pattern; Pattern Recognition; Peripheral; Personality; Persons; Play; Preventive measure; Production; Protocols documentation; Quality of life; Recurrence; Research; Risk; Role; Salivary; Sampling; Seeds; Skinfold Thickness; Speech; Speech Disorders; Stress; Subgroup; Sum; Surface; Technology; Transcranial magnetic stimulation; Treatment Efficacy; Voice; Voice Disorders; Voice Quality; acute stress; base; behavior measurement; behavioral response; career; clinically relevant; cohort; experimental study; improved; indexing; innovation; insight; interest; introvert; motor control; nervous system disorder; neural correlate; neurobiological mechanism; neurological rehabilitation; novel; programs; psychobiologic; relating to nervous system; social; stress reactivity; stressor; success; teacher; theories; trait; vocal cord; vocalization

Project Summary Muscle tension voice disorders such as primary muscle tension dysphonia (pMTD) are common and can profoundly impact quality of life. Precipitating events such as stress and introverted personality are possible factors in pMTD according to the trait theory of voice disorders. This theory proposed neurobiological mechanisms involving behavioral inhibition, but the condition remains an unclassified voice disorder with unknown causes. Large-scale research into the functional and clinical relevance of stressor-dependent limbic- motor interactions using functional MRI (fMRI) to support a neural basis for pMTD is missing. The aims of the project are to (1) determine the functional relevance of stressor-induced limbic activations on the control of voice in the brain in vocally healthy controls, (2) determine the clinical relevance of stressor-induced limbic activations on the control of voice in the brain in those with and without vocal fatigue, and (3) classify extralaryngeal muscular surface electromyography (sEMG) patterns of stress responders and nonresponders with and without vocal fatigue. Sixty female controls and thirty female early career teachers with vocal fatigue (based on Vocal Fatigue Index) between 21-39 years will read sentences with and without exposure to a speech anticipation stressor using a sparse-sampling event-related fMRI protocol. Salivary cortisol analyses will reveal cortisol stress responders and nonresponders. Participants will wear MRI-compatible sEMG electrodes on the anterior neck and complete a corresponding sEMG speech production protocol, but without stressor exposure, outside the scanner on a separate day. Audio data will be recorded to determine changes in vocal effort during speech production. fMRI activations in the laryngeal motor cortex and functional connectivity of core limbic regions will be determined. Further, sEMG patterns of subgroups will be classified, compared, and the total sEMG data correlated with neural (fMRI), psychobiological (cortisol, personality), and vocal function (acoustic) data for all participants and subgroups. The central hypothesis is that laryngeal stress responders have heightened limbic-motor activations involving the limbic vocalization pathway, which correlate with changes in extralaryngeal sEMG activity. In sum, this innovative project will determine neural, psychobiological, and vocal function signatures of stress responders and nonresponders in early career teachers with vocal fatigue and controls. The results will provide fundamentally missing data in our understanding of the role of stress in vocal complaints and will yield new insights about the neural correlates of pMTD. The study findings will have a significant impact on how we identify laryngoresponders for preventative measures and optimize the long-term success of interventions for a broad range of behavioral voice and speech disorders under consideration of neurorehabilitative interventions such as meditation and transcranial magnetic stimulation and wearable sEMG technology.

项目摘要 肌肉紧张性发声障碍，如原发性肌肉紧张性发声障碍（pMTD）是常见的， 深刻影响生活质量。压力和内向性格等令人沮丧的事件是可能的 根据嗓音障碍的特质理论，pMTD的因素。这一理论提出了神经生物学 机制涉及行为抑制，但条件仍然是一个未分类的声音障碍， 原因不明。大规模研究应激依赖性边缘系统的功能和临床相关性， 使用功能性MRI（fMRI）来支持pMTD的神经基础的运动相互作用缺失。的目标 项目是（1）确定应激诱导的边缘系统激活对控制的功能相关性 声音健康对照组的大脑中的声音，（2）确定应激诱导的边缘系统的临床相关性， 在有和没有声音疲劳的人中，大脑中对声音控制的激活，以及（3）分类 应激反应者和无反应者的喉外肌表面肌电图（sEMG）模式 有或没有声音疲劳60名女性对照组和30名女性早期职业教师， （根据声音疲劳指数）21-39岁之间的人会在有和没有接触到一个声音的情况下阅读句子。 使用稀疏采样事件相关功能磁共振成像协议的语音预期应激源。唾液皮质醇分析 将揭示皮质醇应激反应者和无反应者。参与者将佩戴MRI兼容的sEMG 电极在前颈部，并完成相应的sEMG语音产生协议，但没有 压力源暴露，在扫描仪外的另一天。将记录音频数据，以确定 在言语产生过程中的发声努力。喉运动皮层的功能磁共振成像激活和功能连接 核心边缘区的位置将被确定。此外，亚组的sEMG模式将被分类，比较， 总的sEMG数据与神经（功能磁共振成像），心理生物学（皮质醇，个性）和声音相关 所有参与者和亚组的功能（声学）数据。中心假设是喉部压力 反应者的边缘运动激活增强，涉及边缘发声通路， 伴随着喉外表面肌电活动的变化。总之，这个创新的项目将确定神经， 职业生涯早期应激反应者和非应激反应者的心理生物学和发声功能特征 教师与声乐疲劳和控制。这些结果将提供我们的研究中基本缺失的数据。 了解压力在声乐投诉中的作用，并将产生关于神经相关的新见解， pMTD。研究结果将对我们如何识别喉反应者进行预防性治疗产生重大影响。 衡量并优化干预措施的长期成功，以获得广泛的行为声音， 正在考虑神经康复干预的言语障碍，如冥想和经颅 磁刺激和可穿戴表面肌电技术。