Core C: Administrative Core

核心 C：行政核心

• 批准号: 10475020
• 负责人: Cory Abate-Shen
• 金额: $ 15.86万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-11 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475020
• 关键词: Abate; Academic Medical Centers; Area; Bioinformatics; Biometry; Budgets; Cancer Center; Cancer Model; Collaborations; Communication; Conflict (Psychology); Databases; Ensure; Evaluation; Evolution; Feedback; Future; Genomics; Health Insurance Portability and Accountability Act; Human Resources; Individual; Infrastructure; Institution; Investigation; Laboratories; Laboratory Personnel; Leadership; Logistics; Malignant neoplasm of urinary bladder; Memorial Sloan-Kettering Cancer Center; Mission; Modeling; Molecular Analysis; Monitor; Mus; Participant; Pathogenesis; Positioning Attribute; Preparation; Program Reviews; Progress Reports; Reproducibility; Research; Research Personnel; Resolution; Resource Sharing; Resources; Scientist; Secure; Structure; Time; Universities; Work; cloud storage; data management; data resource; data sharing; design; encryption; experience; improved; laboratory experiment; medical schools; meetings; member; molecular pathology; operation; programs; recruit; senior faculty; success; synergism; tumor

Project Summary/Abstract: The Administrative Core will provide coordination and oversight of all activities of the Projects and Cores in this Program, and will maximize interactions and potential synergies among Project Leaders, Core Leaders, and laboratory personnel at the two participating institutions, namely, Columbia University Medical Center (CUMC) and Memorial Sloan Kettering Cancer Center (MSKCC). The major scientific functions of the Core will be to provide expert bioinformatic and biostatistical support for the Projects and other Cores. In addition, to facilitate program integration and effective communication among its various members, the Core will organize monthly meetings composed of two parts: (i) Research presentations, which will include all program participants, as well as relevant Internal Advisory Board members; and (ii) Executive meetings, which will be limited to the Executive Committee (Drs. Abate-Shen, Shen, Solit, and Al-Ahmadie) and members of the Internal Advisory Board. The latter meetings will provide a forum for candid assessment of research progress, oversight of Core utilization, prioritization of resources and objectives, and resolution of potential conflicts. An important function of the Core will be to provide logistical support through management of data and resources, fiscal review and budget analysis, preparation of progress reports, and regulatory compliance. Finally, the Core will organize an annual full-day review of the Program Project by members of the Internal and External Advisory Boards, who will provide detailed feedback on research progress and future directions, as well as advice on program management. This Core will have the following specific aims: (1) To provide bioinformatic and (2) biostatistical support for the Projects, which will be led by co-Investigators, Drs. Barry Taylor (MSKCC) and Tian Zheng (CUMC), respectively. (3) Program management, which will include: (a) Coordination of the overall program by maintaining the organization of the program and establishing mechanisms for effective interaction among its personnel; (b) Data and resource management by promoting effective utilization of Cores A and B, supporting access to secure storage of research presentations and databases, and facilitating data and resource sharing with external laboratories; (c) Review of the Program Project by Internal and External Advisory Boards to evaluate ongoing progress of each Project, review the functionality of the Cores, and provide advice on future research directions. Taken together, the operations of the Administrative Core will ensure the smooth and efficient functioning of the overall Program, as well as planning and oversight for its operations, and will promote the sharing of data and resources within the Program Project as well as with external investigators.

项目概要/摘要： 行政核心将协调和监督项目的所有活动， 本计划的核心，并将最大限度地发挥项目负责人，核心 两个参与机构的领导和实验室人员，即哥伦比亚大学医学院 Memorial Sloan Kettering Cancer Center（MSKCC）的主要科学功能 核心将为项目和其他核心提供生物信息学和生物统计学方面的专家支持。在 此外，为了促进计划的整合和各成员之间的有效沟通， 将组织每月会议，会议由两部分组成：㈠研究报告，其中将包括所有 计划参与者，以及相关的内部咨询委员会成员;（ii）执行会议， 将仅限于执行委员会（Abate-Shen、Shen、Solit和Al-Ahmadie博士）和 内部顾问委员会。后几次会议将为坦率评估研究进展提供一个论坛， 监督核心资源的利用情况，确定资源和目标的优先次序，并解决潜在的冲突。一个 核心的重要职能是通过管理数据和资源提供后勤支助， 财务审查和预算分析、编制进度报告以及法规遵从性。最后，核心 将组织内部和外部的成员对计划项目进行年度全天审查 顾问委员会，就研究进展和未来方向提供详细的反馈，以及 项目管理咨询。 该核心将具有以下具体目标：（1）提供生物信息学和（2）生物统计学支持 对于这些项目，将由共同研究者巴里泰勒博士（MSKCC）和田征博士（JKC）领导， 分别(3)方案管理，包括：（a）通过以下方式协调整个方案： 维持方案的组织，并建立有效互动的机制， （B）数据和资源管理，促进核心A和B的有效利用， 访问研究报告和数据库的安全存储，促进数据和资源共享 （c）由内部和外部咨询委员会审查计划项目， 评估每个项目正在进行的进展，审查核心的功能，并提供未来的建议， 研究方向。总而言之，行政核心的运作将确保顺利进行， 整个计划的有效运作，以及计划和监督其运作，并将 促进项目内部以及与外部调查人员共享数据和资源。