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The Developing Brain: Influences and Outcomes

发育中的大脑：影响和结果

基本信息

批准号：
10475650
负责人：
Viren Andrew D'Sa
金额：
$ 40.48万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475650
关键词：
Address Adolescent Adult Affect Age Behavior Behavior Disorders Behavioral Birth Body Composition Body mass index Brain Brain imaging Caring Child Child Nutrition Childhood Clinical Cognition Cognition Disorders Cognitive Collection Complex Conceptions Cross-Sectional Studies DNA Data Data Set Databases Development Disease Elements Environment Environmental Exposure Environmental Risk Factor Event Exposure to Family history of Fetal Development Fetal Growth Retardation Foundations Future Genetic Genetic Polymorphism Genotype Growth Growth Factor Growth and Development function Health Heterogeneity Human Characteristics Image Individual Infant Intervention Learning Life Link Longitudinal Studies Magnetic Resonance Imaging Maps Masks Measurement Measures Mediating Mental Health Mental disorders Modeling Neurocognitive Neurodegenerative Disorders Neurologic Nutritional Outcome Pattern Police Population Premature Birth Process Public Health Research Design Shapes Sleep Statistical Methods Statistical Models Structure Symptoms Techniques Update Variant Visit base behavioral outcome brain behavior brain shape cognitive development cognitive skill cohort deciduous tooth early childhood early life exposure experience fecal microbiome fetal genetic risk factor gut microbiome holistic approach improved in utero infancy insight lead exposure longitudinal analysis microbiome model development multimodality myelination neural network neurobehavioral neurodevelopment neuroimaging nutrition obesity in children oral microbiome physical conditioning postnatal pressure recruit response serial imaging skills sleep health sociodemographics success synaptic pruning synaptogenesis

项目摘要

PROJECT SUMMARY / DESCRIPTION How does our healthy brain grow? The simplicity of this question masks the highly complex and multifaceted nature of human neurodevelopment. Across fetal development, infancy and early childhood, our brain undergoes remarkable change in response to diverse genetic and environmental pressures. Processes including myelination and synaptogenesis are at their peak across the first 2-3yrs of life, contributing to the emergence of nearly all cognitive and behavioral skills, and laying the foundation for future learning and academic success. While the importance of this early life period to life-long mental health is widely recognized, important questions remain regarding the influences that shape brain growth and cognitive development: 1. How is brain growth altered by specific pre- and post-natal environmental or genetic factors; 2. How are patterns of brain growth associated with, and predictive of, emerging cognitive and behavioral abilities; and 3. How are these brain-behavior relationships influenced by modifiable factors experienced throughout childhood? This proposal seeks to address these fundamental questions using a unique longitudinal neuroimaging dataset that spans fetal, infant and childhood development (22wks to 10yrs of age) and contains more than 2500 measures from ~650 children with diverse birth outcomes, environmental exposures and genotypes. Alongside multimodal MRI, extensive neurocognitive, sociodemographic, physical health, family and medical history, anthropometric, nutrition, sleep, and biospecimen (DNA, oral and fecal microbiome, and shed deciduous teeth) data have been collected on each child and updated at biannual or annual visits. Using this extensive dataset, we aim to address our central hypothesis: that intrauterine events, early life environmental exposures and genetic factors influence cognitive/behavioral outcomes by altering patterns of brain growth. We will examine this hypothesis in three incremental steps. First, we will demonstrate that intrauterine events, early life exposures and specific genetic polymorphisms give rise to altered trajectories of brain development. Next, we will show that differing patterns of neurodevelopment are associated with varying cognitive and behavioral profiles. Finally, we will take a holistic approach and examine how modifiable factors, specifically child nutrition and obesity, sleep health, and our microbiome may mediate these brain-cognition/behavior relationships within the context of related pre- and post-natal environmental and genetic influences. This marks a distinct departure from prior studies, which have typically examined these factors in relative isolation and using cross-sectional study designs. Over the course of this proposal, an additional 500 children will be recruited and 3000 longitudinal measures acquired (bringing the totals to ~1100 children and ~6100 measures). This represents the largest pediatric neuroimaging database that spans birth to 10yrs, and the only that includes fetal and infant measures on the same children. This study and dataset, therefore, represent an unprecedented opportunity to examine the diverse influences, and their complex interactions, that shape brain growth across a fundamental yet understudied period of development.

项目总结/描述

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children.

DOI：
10.1126/sciadv.adi0497
发表时间：
2023-12-22
期刊：
SCIENCE ADVANCES
影响因子：
13.6
作者：
Bonham, Kevin S.;Bottino, Guilherme Fahur;McCann, Shelley Hoeft;Beauchemin, Jennifer;Weisse, Elizabeth;Barry, Fatoumata;Lorente, Rosa Cano;Huttenhower, Curtis;Bruchhage, Muriel;D'Sa, Viren;Deoni, Sean;Klepac-Ceraj, Vanja
通讯作者：
Klepac-Ceraj, Vanja

A New Approach for Functional Connectivity via Alignment of Blood Oxygen Level-Dependent Signals