1/2 Assessing the Cumulative Impact of Early Life Substance and Environment Exposure on Child Neurodevelopment and Health

1/2 评估生命早期物质和环境暴露对儿童神经发育和健康的累积影响

• 批准号: 10381103
• 负责人: Viren Andrew D'Sa
• 金额: $ 1.18万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381103
• 关键词: Achievement; Address; Affect; Age; Analgesics; Area; Attention; Attitude; Behavioral; Birth; Brain; COVID-19; COVID-19 pandemic; California; Child; Child Development; Childhood; Cognitive; Communication; Communities; Complex; Conceptions; County; Data; Data Collection; Development; Economics; Electrocardiogram; Electroencephalography; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Methods; Family; Fentanyl; Foundations; Frequencies; Genetic; Genotype; Growth; Health; Health Care Research; Health Policy; Health Services; Heart; Heroin; Home; Human Characteristics; Individual; Infant; Lead; Learning; Life; Light; Low income; Magnetic Resonance Imaging; Masks; Measurement; Measures; Mediating; Memory; Methods; Mother-Child Relations; National Institute of Drug Abuse; Nature; Neighborhoods; Neonatal Abstinence Syndrome; Neurocognitive; Neurosciences; New England; Newborn Infant; Nutritional; Opioid; Outcome; Parent-Child Relations; Participant; Pathway interactions; Pattern; Physical environment; Physiology; Play; Population; Process; Protocols documentation; Public Health; Recording of previous events; Research; Resources; Rhode Island; Sampling; Sampling Studies; Science; Selection Bias; Services; Shapes; Site; Sleep; Socioeconomic Factors; Structure; Substance Withdrawal Syndrome; System; Time; Tissues; Trust; base; behavioral phenotyping; brain shape; caregiving; cognitive neuroscience; community engagement; data harmonization; demographics; distrust; early childhood; economic disparity; ethnic minority population; experience; fetal; fetal substance exposure; health equity; health inequalities; high dimensionality; in utero; infancy; innovation; multimodality; myelination; neurobehavior; neurodevelopment; neuroimaging; nutrition; opioid epidemic; peer; phenotypic data; postnatal; pregnant; prenatal; prenatal exposure; psychosocial; racial disparity; racial equality; racial minority; racism; relating to nervous system; repository; skills; social; social capital; social equality; socioeconomics; study population; substance use; synaptogenesis; treatment services; visual tracking

PROJECT SUMMARY / DESCRIPTION What are the neurodevelopmental sequelae of in utero opiate and other substance exposure? The succinct nature of this question masks the complex and multifaceted nature of human neurodevelopment, and the diversity of environmental influences that can mediate or moderate the initial direct effects substances may have on the developing brain. From conception to age 10, our brain undergoes remarkable structural and functional growth. Neurodevelopmental processes that include myelination and synaptogenesis are at their peak, responding to integrative cascades of genetic and environmental interactions as they mature neural systems and provide the foundation for emerging cognitive and behavioral skills. The patterns of this early development reflects adaptation to the child's direct and contextual environments and, thus, the potential impact of in utero substance exposures must be considered within the broader family, psychosocial, economic, and physical environment. Over the past year, these environments have witnessed unprecedented upheaval as a result of the COVID-19 pandemic, impacting children, families, and pregnant individuals with disproportionate impact on lower-income, and racial and ethnic minority families - the very families already shaken by the ongoing opioid crisis. Our proposal aims to understand the neurodevelopmental impact of these converging experiences. We will collect deep multi-level and repeat neuroimaging and behavioral phenotype data, alongside rich contextual measures of environmental exposures centered on the child's lived experience, including social equity and socioeconomic factors. Building from a central hypothesis that brain development is an integrative process that is shaped by prenatal insults (opiate and other substance exposures) and ongoing postnatal influences against a backdrop of social,economic, and health inequalities we will: 1. Characterize the variability of `neurotypical' development, recognizing that multiple pathways reflecting individual adaption may lead to the same outcomes; 2. Examine how in utero substance exposures alter these patterns and pathways; and 3. Take a holistic and integrated approach to understanding how the diversity of a child's environment shapes and modifies brain patterns and outcomes. Achievement of these aims requires a careful and purposefully planned study with unbiased measures, community partners, and representative socioeconomic and demographic populations - communities with well-founded distrust of research and public health workers. At the heart of our proposal is the principle of access. We will reduce traditional barriers to participation using innovative data collection methods and mobile labs to bring the research to under-represented and marginalized communities; and build trusted connections with our participating families through our established community advisory boards and peer navigator networks. Our approach, therefore, aims to clarify the impact of substance exposure on child development whilst shifting the field of developmental neuroscience and substance use to a more equitable standard of research, with generalizable findings that can guide non-punitive public health policies.

项目概要/描述 子宫内阿片类药物和其他物质暴露的神经发育后遗症是什么？简洁的 这个问题的本质掩盖了人类神经发育的复杂性和多面性， 环境影响的多样性，可以调解或缓和物质可能具有的初始直接效应 对大脑发育的影响从受孕到10岁，我们的大脑经历了显著的结构和功能变化， 增长包括髓鞘形成和突触发生在内的神经发育过程处于高峰期， 随着神经系统的成熟，对遗传和环境相互作用的综合级联反应 并为新兴的认知和行为技能提供基础。这种早期发展的模式 反映了对孩子的直接和背景环境的适应，因此， 物质暴露必须在更广泛的家庭、心理社会、经济和身体范围内加以考虑。 环境在过去一年中，这些环境经历了前所未有的动荡， 2019冠状病毒病大流行，影响儿童、家庭和孕妇，对 低收入、种族和少数民族家庭--这些家庭已经被正在进行的阿片类药物所动摇 危机我们的建议旨在了解这些融合经验对神经发育的影响。我们 将收集深层次的多层次和重复的神经成像和行为表型数据，以及丰富的上下文 以儿童的生活经历为中心的环境暴露措施，包括社会公平， 社会经济因素。从一个中心假设，即大脑发育是一个整合的过程， 是由产前侮辱（阿片类药物和其他物质的暴露）和持续的产后影响， 在社会、经济和健康不平等的背景下，我们将：1。描述“神经型”的变异性 发展，认识到反映个人适应的多种途径可能导致相同的结果; 2.检查子宫内物质暴露如何改变这些模式和途径; 3.做一个全面的检查， 一种综合的方法来理解儿童环境的多样性如何塑造和改变大脑 模式和结果。实现这些目标需要认真和有目的的计划研究， 公正的措施，社区合作伙伴，以及代表性的社会经济和人口- 社区对研究和公共卫生工作者有充分的不信任。我们建议的核心是 准入原则。我们将利用创新的数据收集方法减少传统的参与障碍 和移动的实验室，将研究带到代表性不足和边缘化的社区;并建立可信的 通过我们建立的社区咨询委员会和同行与我们的参与家庭建立联系 导航网络因此，我们的方法旨在阐明物质暴露对儿童的影响。 发展，同时将发展神经科学和物质使用领域转移到更公平的 研究标准，具有可指导非惩罚性公共卫生政策的可推广研究结果。