UAB Pilot Center for Precision Animal Modeling (C-PAM) - Preclinical/Co-Clinical Section

UAB 精密动物建模试点中心 (C-PAM) - 临床前/临床联合部分

基本信息

项目摘要

ABSTRACT (PRE/CO-CLINICAL SECTION) The Preclinical/Co-Clinical Section (PCS) provides a critical link between affected individuals and referring clinicians and the C-PAM. Guiding principles are 1) to maintain a dialog with affected individuals and referring clinicians to ensure that adequate information is available to prioritize creation of a model and to validate the model, and 2) to engage affected individuals and referring clinicians as partners, providing updates on progress in a responsible manner. We expect to receive nominations for creation of an animal model from several ongoing programs at UAB that have an existing queue of genomic variants for analysis, as well as from sources outside of UAB. The PCS will provide a secure web-based gateway for accession of clinical information, obtained with the informed consent of participants. The PCS team will review this information and summarize it in a PhenoTips entry. This in turn will be used to generate a Variant Phenopacket (VPP), which will include human phenotype ontology terms related to the affected individual's phenotype along with relevant genotypic information. There will also be the capacity to obtain and store biological samples, such as blood, urine, saliva, and surgical specimens, if needed. The VPP will be passed onto the Bioninformatics Section for further analysis, leading ultimately to information to guide a decision by the Steering Committee of whether to create a model. Once a model is made, the PCS will work together with the Disease Modeling Unit to provide co-clinical assessments. If the model is one that might demonstrate a phenotype similar to that seen in the affected individual, the PCS will help to validate the model phenotype in light of the clinical phenotype. Often this will require going back to the affected individual or referring clinician for additional phenotypic information. In other cases, the model will address cellular function altered by the genomic variant. Further validation of this finding might require additional studies in tissue obtained from the affected individual. The PCS will also work with the Disease Modeling Unit in studies of potential therapies. In some instances, a drug or substance might be identified that is recognized as having potential therapeutic benefit. In other instances, the creation of the model might enable a drug discovery effort. In either case, the PCS will work with the Disease Modeling Unit to assess potential therapies. If results shed light on the pathogenicity of a variant or on the availability of a possible treatment, these will be reviewed by a Clinical Curation Committee before any information is shared with the referring physician. Ultimately, if approved by the committee and the affected individual has opted into learning of such information, the PCS physician will communicate with the referring physician. Otherwise, general information on research progress will be maintained on the C-PAM portal to keep the affected individual and referring physician apprised of general progress.
摘要(临床前/协同临床部分) 临床前/协同临床部分(PCS)提供了受影响个体和转诊之间的关键联系 临床医生和C-PAM。指导原则是:1)与受影响的个人保持对话, 临床医生确保有足够的信息可用于优先创建模型并验证 模型,以及2)让受影响的个人和转介临床医生作为合作伙伴,提供最新进展 以负责任的方式。我们希望从几个正在进行的动物模型创建中获得提名 UAB的程序,这些程序具有用于分析的基因组变体的现有队列,以及来自外部的来源 关于UAB PCS将提供一个安全的基于Web的网关,用于访问通过以下方式获得的临床信息 参与者的知情同意。PCS团队将审查这些信息,并将其总结在PhenoTips中。 入境这反过来将用于生成变体表型包(VPP),其中将包括人类表型 与受影响个体的表型沿着相关基因型信息相关的本体术语。那里 也将是获取和存储生物样本的能力,如血液,尿液,唾液和手术 如果需要的话,还可以做标本。VPP将被传递到生物信息学部分进行进一步分析, 最终,指导委员会将信息用于指导是否创建模型的决定。一次 在制作模型后,PCS将与疾病模型组合作,提供临床评估。 如果该模型可能表现出与受影响个体相似的表型, 将有助于根据临床表型验证模型表型。通常这需要回到 受影响的个体或转诊临床医生以获得额外的表型信息。在其他情况下,模型将 解决由基因组变体改变的细胞功能。进一步验证这一发现可能需要额外的 从受影响的个体获得的组织中进行的研究。PCS还将与疾病建模股合作, 研究潜在的治疗方法。在某些情况下,可能会识别出一种药物或物质, 具有潜在的治疗益处。在其他情况下,模型的创建可能使药物 探索的努力在这两种情况下,PCS将与疾病建模部门合作,以评估潜在的治疗方法。 如果结果揭示了变异的致病性或可能的治疗方法的可用性, 在与转诊医生共享任何信息之前,由临床治疗委员会审查。 最终,如果得到委员会的批准,并且受影响的个人选择了解这些信息, PCS医生将与转诊医生进行通信。否则,研究的一般信息 将在C-PAM门户网站上保持进展,以通知受影响的个人和转诊医生 普遍进步。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Matthew Brendon Might其他文献

Matthew Brendon Might的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Matthew Brendon Might', 18)}}的其他基金

UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB 精密动物建模试点中心 (C-PAM)
  • 批准号:
    10477301
  • 财政年份:
    2020
  • 资助金额:
    $ 21.75万
  • 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB 精密动物建模试点中心 (C-PAM)
  • 批准号:
    10260614
  • 财政年份:
    2020
  • 资助金额:
    $ 21.75万
  • 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB 精密动物建模试点中心 (C-PAM)
  • 批准号:
    10793200
  • 财政年份:
    2020
  • 资助金额:
    $ 21.75万
  • 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM)
UAB 精密动物建模试点中心 (C-PAM)
  • 批准号:
    10661435
  • 财政年份:
    2020
  • 资助金额:
    $ 21.75万
  • 项目类别:
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Preclinical/Co-Clinical Section
UAB 精密动物建模试点中心 (C-PAM) - 临床前/临床联合部分
  • 批准号:
    10260616
  • 财政年份:
    2020
  • 资助金额:
    $ 21.75万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 21.75万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了