Genomic causes and consequences of sexually antagonistic selection

性对抗选择的基因组原因和后果

基本信息

批准号：
10477347
负责人：
Mark Kirkpatrick
金额：
$ 38.67万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-17 至 2024-08-31
项目状态：
已结题

项目摘要

Project Summary / Abstract Sexually antagonistic selection (or SAS) acts when an allele is beneficial to one sex but deleterious to the other. It is thought to be important to the maintenance of genetic diseases, variation in social behaviors, and evolution of genome structure. Despite its importance to evolution, we know little about the genomic impact of SAS in natural populations because the classical tools of molecular evolution cannot detect it. This project will advance our understanding of SAS in two dimensions: Aim 1 will use new methods to detect SAS by measuring the small differences between allele frequencies in males and females that result from SAS acting in the current generation. Individually, these differences are rarely statistically significant, but we recently discovered that these differences can be aggregated across the genome to detect and quantify SAS. We will apply this strategy to large samples of whole genomes from natural populations of stickleback fishes that differ in their degree of sexual dimorphism. The results will provide the first estimates of the genome-wide strength of SAS, and the total amount of mortality imposed on males and females because individuals carry alleles that are adapted to the other sex. Aim 2 will provide the first systematic test of the prevailing hypothesis that SAS drives transitions between XY and ZW sex chromosome systems. These transitions are key events in genome evolution: they rewire the sex determination pathway, can trigger the degeneration of the Y or W chromosome, and have downstream effects on population demography. While theory shows these transitions can result from SAS, no systematic test of the hypothesis has been carried out. The research will focus on poeciliid fishes that vary both within and between species for XY and ZW sex determination. A novel strategy will be used to obtain the phased sequences of X, Y, Z, and W chromosomes. Gene trees for these chromosomes will show the sequence in which they evolved, test a key prediction of the SAS hypothesis, and give unprecedented views of very young W sex chromosomes. The research will have two major kinds of broader impacts. (i) It will develop a new approach for detecting selection acting contemporaneously, and determining its demographic impact. The strategy is a major departure from current methods, which rely on genetic signatures that only accumulate over many generations. The new methods will have applications to diverse forms of selection and to other species, including humans. (ii) The project will develop poeciliid fishes as the first model system in which all four types of sex chromosomes (X, Y, Z, and W) can be studied. Important new research horizons will be opened, for example revealing how confining a sex chromosome to females (the W) alters the mode and tempo of its evolution.

项目摘要 /摘要当等位基因对一种性别有益，但对此有害时，性拮抗选择（或SAS）会起作用其他。人们认为这对于维持遗传疾病，社会行为的差异和基因组结构的演变。尽管它对进化的重要性，但我们对天然种群中的SAS是因为分子进化的经典工具无法检测到它。这个项目将提高我们对SAS在两个维度上的理解： AIM 1将使用新方法来检测SAS，通过测量等位基因频率之间的较小差异由SAS在当前一代起作用的男性和女性。单独，这些差异是很少有统计学意义，但我们最近发现这些差异可以在整个基因组检测和量化SAS。我们将将此策略应用于大量的全基因组样本其性二态性程度有所不同的粘性鱼类天然种群。结果将提供对SAS全基因组强度的首次估计，并施加的死亡率总数男性和女性是因为个体携带适合他人的等位基因。 AIM 2将对现行假设提供首次系统测试，即SAS驱动XY之间的过渡和ZW性别染色体系统。这些过渡是基因组进化中的关键事件：它们重新连接性别确定途径，可以触发Y或W染色体的变性，并具有下游效应关于人口统计学。虽然理论表明这些过渡可能是由SAS引起的，但没有系统的测试该假设已经进行。这项研究将重点介绍在内部和内部各种的poeciliid鱼类上在XY和ZW性别确定的物种之间。新颖的策略将用于获得分阶段 X，Y，Z和W染色体的序列。这些染色体的基因树将显示他们进化了，测试了SAS假设的关键预测，并给出了非常年轻的前所未有的观点 W性染色体。这项研究将产生两种主要的广泛影响。（i）它将开发一种新方法来检测选择同时行动，并确定其人口影响。该策略是主要的偏离当前方法，这些方法依赖于仅在许多世代积累的遗传特征。新方法将应用于各种形式的选择形式和包括人类在内的其他物种。（ii）该项目将开发Poeciliid鱼类作为第一个模型系统，其中所有四种性别可以研究染色体（X，Y，Z和W）。例如，重要的新研究视野将被打开揭示了将性染色体局限于女性（w）如何改变其进化的模式和速度。

项目成果

期刊论文数量（29）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Limited Introgression between Rock-Wallabies with Extensive Chromosomal Rearrangements.

DOI：
10.1093/molbev/msab333
发表时间：
2022-01-07
期刊：
Molecular biology and evolution
影响因子：
10.7
作者：
Potter S;Bragg JG;Turakulov R;Eldridge MDB;Deakin J;Kirkpatrick M;Edwards RJ;Moritz C
通讯作者：
Moritz C

Chromosomal Fusions Facilitate Adaptation to Divergent Environments in Threespine Stickleback.

DOI：
10.1093/molbev/msab358
发表时间：
2022-02-03
期刊：
Molecular biology and evolution
影响因子：
10.7
作者：
Liu Z;Roesti M;Marques D;Hiltbrunner M;Saladin V;Peichel CL
通讯作者：
Peichel CL

Searching for signatures of sexually antagonistic selection on stickleback sex chromosomes.

DOI：
10.1098/rstb.2021.0205
发表时间：
2022-08
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
影响因子：
6.3
作者：
Dagilis, Andrius J.;Sardell, Jason M.;Josephson, Matthew P.;Su, Yiheng;Kirkpatrick, Mark;Peichel, Catherine L.
通讯作者：
Peichel, Catherine L.

Sex chromosomes manipulate mate choice.

性染色体控制配偶选择。