A photoplethysmography sensor-based personalized feedback intervention for heavy-drinking young adults targeting heart rate variability, resting heart rate, and sleep

摘要 据报道，年轻人酗酒的比例最高，是预防和预防酗酒的优先人群 干预努力。利用其他健康问题并利用技术的酒精战略可能 提供创新的解决方案。采用这种方法，我们进行了第一次移动睡眠的初步测试 让酗酒的年轻人参与治疗的干预措施，并显示出对饮酒的良好效果。 这项初步研究和我们目前的后续研究(R34AA026021)的数据产生了新的假设 以及改进这种移动干预的方向。具体地说，酗酒的年轻人希望 关于他们健康状况的反馈，以及他们如何通过减少饮酒和改善健康状况来改善健康状况 睡吧。因此，为了优化针对年轻人的个性化酒精反馈的有效性，我们建议 将其嵌入更全面的健康反馈计划中，并将饮酒不仅与睡眠联系起来，而且 也适用于强大的非侵入性健康生物标志物-静息心率(RHR)和心率变异性(HRV)， 后者尤其受到酗酒和睡眠不佳的影响。此外，我们还将 采用新的传感器技术，利用光体积描记术(PPG)获得日常被动采集 可以连接到移动应用程序以提供基于这些数据的反馈的HRV、RHR和睡眠。在……里面 一项关于PPG传感器和集成移动应用程序的初步研究，用户注意到他们的 饮酒和睡眠/健康数据促使他们减少饮酒。因此，PPG技术 有必要对酒精预防和早期干预进行进一步研究。目前的提案将进行第一次 通过PPG传感器和PPG传感器对针对HRV、RHR和睡眠的反馈/简短建议干预进行受控测试 为大量饮酒的年轻人提供电子日记，并将利用市场上PPG的好处 传感器和移动应用程序OURATM。我们将把受试者随机分为：(1)评估(n=30)或(2)反馈 (n=30)。所有受试者将佩戴OURA™，并在6周内完成每日电子日记，并参加后续- 6周和10周的UPS。评估中的受试者将只监测他们的健康/行为，不会收到 任何健康反馈或建议。反馈中的受试者将监测他们的健康/行为，并每天接受 来自Oura™应用程序的健康信息以及与酒精相关的双周健康反馈/建议 根据OURA™和日记数据得出：(1)酒精使用摘要以及饮酒和饮酒之间的联系 OURA™健康生物标记物和(2)根据这一数据量身定做的循证简短的酒精和睡眠建议。这 研究将产生重要的初步数据，以支持对这种新方法进行更大规模的调查， 喝酒的年轻人。大量饮酒的年轻人可能非常适合移动健康反馈 考虑到他们对科技的偏好和不常饮酒的情况，将酒精含量纳入干预措施有助于- 寻找。

Abstract Young adults report the highest rates of heavy drinking and are a priority population for alcohol prevention and intervention efforts. Alcohol strategies that leverage their other health concerns and utilize technology may offer an innovative solution. Taking this approach, we conducted the first preliminary test of a mobile sleep intervention to engage heavy-drinking young adults in treatment and showed promising effects on drinking. Data from this pilot study and our current follow-up study (R34AA026021) have generated new hypotheses and directions for refinement of this mobile intervention. Specifically, heavy-drinking young adults want feedback about their health status and how they can improve it by reducing their drinking and improving their sleep. Thus, to optimize the effectiveness of personalized alcohol feedback for young adults, we propose to embed it within a more comprehensive health feedback program and connect alcohol use not only to sleep but also to robust, non-invasive health biomarkers – resting heart rate (RHR) and heart rate variability (HRV), with the latter particularly affected by heavy alcohol use and potentially by poor sleep. In addition, we will incorporate new sensor technology that utilizes photoplethysmography (PPG) to obtain daily, passive collection of HRV, RHR, and sleep that can be connected to mobile apps to provide feedback based on these data. In one preliminary study of a PPG sensor and integrated mobile app, users who noted a link between their alcohol use and sleep/health data were motivated to reduce their drinking. Therefore, PPG technology warrants further study for alcohol prevention and early intervention. The current proposal will conduct the first controlled test of a feedback/brief advice intervention targeting HRV, RHR, and sleep via PPG sensors and electronic daily diaries for heavy-drinking young adults and will leverage the benefits of a marketed PPG sensor and mobile app, OURATM. We will randomize subjects to: (1) Assessment (n=30) or (2) Feedback (n=30). All subjects will wear an OURA™ and complete daily electronic diaries for 6 weeks and attend follow- ups at Weeks 6 and 10. Subjects in Assessment will only monitor their health/behaviors and will not receive any health feedback or advice. Subjects in Feedback will monitor their health/behaviors and receive daily health information from the OURA™ app as well as bi-weekly alcohol-related health feedback/advice that we derive from the OURA™ and diary data: (1) summaries of alcohol use and the links between drinking and OURA™ health biomarkers and (2) evidence-based brief alcohol and sleep advice tailored to this data. This study will yield important preliminary data to support a larger investigation of this novel approach with heavy- drinking young adults. Heavy-drinking young adults may be ideally suited for mobile health feedback interventions that incorporate alcohol content given their preference for technology and infrequent alcohol help- seeking.