Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania

乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系

• 批准号: 10478908
• 负责人: Simon Kasasa
• 金额: $ 12.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478908
• 关键词: AIDS/HIV problem; Africa; Africa South of the Sahara; Age; Air; Area; Biological Specimen Banks; Cancer Etiology; Caring; Cessation of life; Clinical; Clinical Distribution; Cohort Analysis; Collaborations; Cross-Sectional Studies; Data; Databases; Diagnosis; Disease; ERBB2 gene; Epidemiologist; Epidemiology; Epidermal Growth Factor Receptor; Etiology; Female; Genomics; Guidelines; HIV; HIV Infections; HIV-1; Health Personnel; Histology; Histopathology; Image; Incidence; Individual; Infection; KRAS2 gene; Knowledge; Laboratories; Life; Link; Logistic Regressions; Lung nodule; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Modeling; Modification; Molecular; Mutation; Outcome; Patients; Persons; Phase; Physicians; Prevalence; Prevention program; Primary Prevention; ROS1 gene; Recurrence; Reporting; Research Proposals; Risk; Risk Factors; Role; Savings; Series; Sex Differences; Smoking; Smoking Behavior; Smoking Status; Somatic Mutation; Standardization; Tanzania; Thoracic Radiography; Time; Uganda; Universities; Woman; World Health Organization; antiretroviral therapy; base; cancer risk; cancer survival; case control; clinical epidemiology; design; innovation; lifetime risk; low and middle-income countries; male; men; mortality; multidisciplinary; personalized medicine; radiological imaging; residence; screening; screening program; sex; survival outcome; tumor progression

ABSTRACT – Project 1 The innovation of our research proposal focuses on three main areas: 1) primary prevention; 2) screening; and 3) personalized medicine. Currently, several studies in the US and Africa have demonstrated that HIV-1 infection increases the risk of lifetime cancer risk, particularly lung cancer. The etiology of lung cancer among HIV-1 infected individuals is unknown, but of great importance given the number of individuals who live infected with HIV-1. Here we will investigate potential risk factors for lung cancer such as geospatial residence, indoor and outdoor air quality, and smoking behavior to better understand the underlying risk factors. This general knowledge will serve to develop primary prevention programs designed to reduce adverse exposures thus lowering the onset of lung cancer disease. Beyond primary prevention, our proposal will assess clinical features associated with lung cancer risk and progression among those infected by HIV-1. This will provide the opportunity to develop screening programs based on HIV-1 infection status thus detecting disease at an earlier phase and decreasing the overall mortality. For example, TB may present as lung nodules during chest x-rays and patients who actually have lung cancer have a delay in the diagnosis of lung cancer and life-saving treatments. Understanding this relationship will better enable physicians and health providers to provide comprehensive screening. Lastly, our proposal will expand the concept of personalized medicine by providing a descriptive analysis of somatic genomic mutations among lung cancer cases infected with HIV-1. This will provide the basis to examine for differences and provide optimal care under current guidelines.

摘要-项目1 我们研究方案的创新集中在三个主要领域：1)初级预防；2)筛查；以及 3)个性化用药。目前，美国和非洲的几项研究表明，艾滋病毒-1感染 增加终生罹患癌症的风险，尤其是肺癌。HIV-1中肺癌的病原学研究 感染的人是未知的，但考虑到感染了病毒的人数，这一点非常重要 HIV-1。在这里，我们将调查肺癌的潜在危险因素，如地理空间居住、室内和 室外空气质量和吸烟行为，以更好地了解潜在的危险因素。这位将军 知识将有助于制定旨在减少不良暴露的初级预防计划，从而 降低肺癌发病率。除了初级预防之外，我们的建议还将评估临床特征 与HIV-1感染者中的肺癌风险和进展有关。这将提供一个机会 根据HIV-1感染状况制定筛查计划，以便在早期阶段发现疾病，以及 降低总死亡率。例如，在胸部x光检查和患者的治疗过程中，结核病可能表现为肺结节。 那些实际患有肺癌的人在肺癌的诊断和挽救生命的治疗方面存在延误。 了解这种关系将更好地使医生和卫生保健提供者能够提供全面的 放映。最后，我们的提案将通过提供描述性的 HIV-1感染的肺癌患者体细胞基因组突变分析。这将为以后的研究提供依据 在目前的指导方针下，检查差异并提供最佳护理。