Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania

乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系

• 批准号: 10478908
• 负责人: Simon Kasasa
• 金额: $ 12.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478908
• 关键词: AIDS/HIV problem; Africa; Africa South of the Sahara; Age; Air; Area; Biological Specimen Banks; Cancer Etiology; Caring; Cessation of life; Clinical; Clinical Distribution; Cohort Analysis; Collaborations; Cross-Sectional Studies; Data; Databases; Diagnosis; Disease; ERBB2 gene; Epidemiologist; Epidemiology; Epidermal Growth Factor Receptor; Etiology; Female; Genomics; Guidelines; HIV; HIV Infections; HIV-1; Health Personnel; Histology; Histopathology; Image; Incidence; Individual; Infection; KRAS2 gene; Knowledge; Laboratories; Life; Link; Logistic Regressions; Lung nodule; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Modeling; Modification; Molecular; Mutation; Outcome; Patients; Persons; Phase; Physicians; Prevalence; Prevention program; Primary Prevention; ROS1 gene; Recurrence; Reporting; Research Proposals; Risk; Risk Factors; Role; Savings; Series; Sex Differences; Smoking; Smoking Behavior; Smoking Status; Somatic Mutation; Standardization; Tanzania; Thoracic Radiography; Time; Uganda; Universities; Woman; World Health Organization; antiretroviral therapy; base; cancer risk; cancer survival; case control; clinical epidemiology; design; innovation; lifetime risk; low and middle-income countries; male; men; mortality; multidisciplinary; personalized medicine; radiological imaging; residence; screening; screening program; sex; survival outcome; tumor progression

ABSTRACT – Project 1 The innovation of our research proposal focuses on three main areas: 1) primary prevention; 2) screening; and 3) personalized medicine. Currently, several studies in the US and Africa have demonstrated that HIV-1 infection increases the risk of lifetime cancer risk, particularly lung cancer. The etiology of lung cancer among HIV-1 infected individuals is unknown, but of great importance given the number of individuals who live infected with HIV-1. Here we will investigate potential risk factors for lung cancer such as geospatial residence, indoor and outdoor air quality, and smoking behavior to better understand the underlying risk factors. This general knowledge will serve to develop primary prevention programs designed to reduce adverse exposures thus lowering the onset of lung cancer disease. Beyond primary prevention, our proposal will assess clinical features associated with lung cancer risk and progression among those infected by HIV-1. This will provide the opportunity to develop screening programs based on HIV-1 infection status thus detecting disease at an earlier phase and decreasing the overall mortality. For example, TB may present as lung nodules during chest x-rays and patients who actually have lung cancer have a delay in the diagnosis of lung cancer and life-saving treatments. Understanding this relationship will better enable physicians and health providers to provide comprehensive screening. Lastly, our proposal will expand the concept of personalized medicine by providing a descriptive analysis of somatic genomic mutations among lung cancer cases infected with HIV-1. This will provide the basis to examine for differences and provide optimal care under current guidelines.

摘要 - 项目1 我们的研究建议的创新侧重于三个主要领域：1）主要预防； 2）筛选；和 3）个性化医学。目前，美国和非洲的几项研究表明HIV-1感染 增加了终生癌症风险的风险，尤其是肺癌。 HIV-1中肺癌的病因 受感染的人未知，但鉴于被感染的个人人数很重要 HIV-1。在这里，我们将调查肺癌的潜在危险因素，例如地理空间居住，室内和 户外空气质量和吸烟行为，以更好地了解潜在的危险因素。这个将军 知识将有助于制定旨在减少不良暴露的主要预防计划 降低肺癌疾病的发作。除了初级预防之外，我们的建议还将评估临床特征 与HIV-1感染的肺癌风险和进展有关。这将提供机会 基于HIV-1感染状况制定筛查计划，从而在早期阶段检测疾病 降低整体死亡率。例如，胸部X射线和患者期间，结核病可能以肺结节形式出现 实际上患有肺癌的人在诊断肺癌和挽救生命的治疗方面延迟。 了解这种关系将更好地使医生和健康提供者提供全面 筛选。最后，我们的建议将通过提供描述性来扩大个性化医学的概念 对感染HIV-1的肺癌病例中体细胞基因组突变的分析。这将提供基础 检查差异并根据当前准则提供最佳护理。