Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania

乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系

• 批准号: 10084627
• 负责人: Simon Kasasa
• 金额: $ 12.73万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10084627
• 关键词: AIDS/HIV problem; Africa; Africa South of the Sahara; Age; Air; Area; Biological Specimen Banks; Cancer Etiology; Caring; Cessation of life; Clinical; Clinical Distribution; Cohort Analysis; Collaborations; Cross-Sectional Studies; Data; Databases; Diagnosis; Diagnostic radiologic examination; Disease; ERBB2 gene; Epidemiologist; Epidemiology; Epidermal Growth Factor Receptor; Etiology; Female; Genomics; Guidelines; HIV; HIV Infections; HIV-1; Health Personnel; Histology; Histopathology; Image; Incidence; Individual; Infection; KRAS2 gene; Knowledge; Laboratories; Life; Link; Logistic Regressions; Lung nodule; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Modeling; Modification; Molecular; Mutation; Outcome; Patients; Persons; Phase; Physicians; Prevalence; Prevention program; Primary Prevention; ROS1 gene; Recurrence; Reporting; Research Proposals; Risk; Risk Factors; Role; Savings; Series; Sex Differences; Smoking; Smoking Behavior; Smoking Status; Somatic Mutation; Standardization; Tanzania; Thoracic Radiography; Time; Uganda; Universities; Woman; World Health Organization; antiretroviral therapy; base; cancer risk; cancer survival; case control; clinical epidemiology; design; innovation; lifetime risk; low and middle-income countries; male; men; mortality; multidisciplinary; personalized medicine; residence; screening; screening program; sex; survival outcome; tumor progression

ABSTRACT – Project 1 The innovation of our research proposal focuses on three main areas: 1) primary prevention; 2) screening; and 3) personalized medicine. Currently, several studies in the US and Africa have demonstrated that HIV-1 infection increases the risk of lifetime cancer risk, particularly lung cancer. The etiology of lung cancer among HIV-1 infected individuals is unknown, but of great importance given the number of individuals who live infected with HIV-1. Here we will investigate potential risk factors for lung cancer such as geospatial residence, indoor and outdoor air quality, and smoking behavior to better understand the underlying risk factors. This general knowledge will serve to develop primary prevention programs designed to reduce adverse exposures thus lowering the onset of lung cancer disease. Beyond primary prevention, our proposal will assess clinical features associated with lung cancer risk and progression among those infected by HIV-1. This will provide the opportunity to develop screening programs based on HIV-1 infection status thus detecting disease at an earlier phase and decreasing the overall mortality. For example, TB may present as lung nodules during chest x-rays and patients who actually have lung cancer have a delay in the diagnosis of lung cancer and life-saving treatments. Understanding this relationship will better enable physicians and health providers to provide comprehensive screening. Lastly, our proposal will expand the concept of personalized medicine by providing a descriptive analysis of somatic genomic mutations among lung cancer cases infected with HIV-1. This will provide the basis to examine for differences and provide optimal care under current guidelines.

摘要 – 项目 1 我们的研究方案的创新主要集中在三个领域：1）一级预防； 2）筛选；和 3）个性化医疗。目前，美国和非洲的多项研究表明，HIV-1感染 增加终生患癌症的风险，尤其是肺癌。 HIV-1肺癌的病因学 感染者人数尚不清楚，但考虑到感染者人数，这一点非常重要 HIV-1。在这里，我们将调查肺癌的潜在危险因素，例如地理空间居住、室内和室外环境等。 室外空气质量和吸烟行为，以更好地了解潜在的危险因素。这个一般 知识将有助于制定旨在减少不良暴露的初级预防计划，从而 降低肺癌疾病的发病率。除了一级预防之外，我们的提案还将评估临床特征 与 HIV-1 感染者的肺癌风险和进展相关。这将提供机会 制定基于 HIV-1 感染状况的筛查计划，从而及早发现疾病 降低总体死亡率。例如，结核病可能在胸部 X 光检查中表现为肺部结节，并且患者 真正患有肺癌的人会延迟肺癌的诊断和挽救生命的治疗。 了解这种关系将使医生和医疗服务提供者能够更好地提供全面的服务 筛选。最后，我们的建议将通过提供描述性的内容来扩展个性化医疗的概念 HIV-1感染肺癌病例体细胞基因组突变分析。这将提供基础 检查差异并根据现行指南提供最佳护理。