Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania

乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系

• 批准号: 10267198
• 负责人: Simon Kasasa
• 金额: $ 10.48万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-21 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10267198
• 关键词: AIDS/HIV problem; Africa; Africa South of the Sahara; Age; Air; Area; Biological Specimen Banks; Cancer Etiology; Caring; Cessation of life; Clinical; Clinical Distribution; Cohort Analysis; Collaborations; Cross-Sectional Studies; Data; Databases; Diagnosis; Diagnostic radiologic examination; Disease; ERBB2 gene; Epidemiologist; Epidemiology; Epidermal Growth Factor Receptor; Etiology; Female; Genomics; Guidelines; HIV; HIV Infections; HIV-1; Health Personnel; Histology; Histopathology; Image; Incidence; Individual; Infection; KRAS2 gene; Knowledge; Laboratories; Life; Link; Logistic Regressions; Lung nodule; Malignant Neoplasms; Malignant neoplasm of lung; Mediating; Modeling; Modification; Molecular; Mutation; Outcome; Patients; Persons; Phase; Physicians; Prevalence; Prevention program; Primary Prevention; ROS1 gene; Recurrence; Reporting; Research Proposals; Risk; Risk Factors; Role; Savings; Series; Sex Differences; Smoking; Smoking Behavior; Smoking Status; Somatic Mutation; Standardization; Tanzania; Thoracic Radiography; Time; Uganda; Universities; Woman; World Health Organization; antiretroviral therapy; base; cancer risk; cancer survival; case control; clinical epidemiology; design; innovation; lifetime risk; low and middle-income countries; male; men; mortality; multidisciplinary; personalized medicine; residence; screening; screening program; sex; survival outcome; tumor progression

ABSTRACT – Project 1 The innovation of our research proposal focuses on three main areas: 1) primary prevention; 2) screening; and 3) personalized medicine. Currently, several studies in the US and Africa have demonstrated that HIV-1 infection increases the risk of lifetime cancer risk, particularly lung cancer. The etiology of lung cancer among HIV-1 infected individuals is unknown, but of great importance given the number of individuals who live infected with HIV-1. Here we will investigate potential risk factors for lung cancer such as geospatial residence, indoor and outdoor air quality, and smoking behavior to better understand the underlying risk factors. This general knowledge will serve to develop primary prevention programs designed to reduce adverse exposures thus lowering the onset of lung cancer disease. Beyond primary prevention, our proposal will assess clinical features associated with lung cancer risk and progression among those infected by HIV-1. This will provide the opportunity to develop screening programs based on HIV-1 infection status thus detecting disease at an earlier phase and decreasing the overall mortality. For example, TB may present as lung nodules during chest x-rays and patients who actually have lung cancer have a delay in the diagnosis of lung cancer and life-saving treatments. Understanding this relationship will better enable physicians and health providers to provide comprehensive screening. Lastly, our proposal will expand the concept of personalized medicine by providing a descriptive analysis of somatic genomic mutations among lung cancer cases infected with HIV-1. This will provide the basis to examine for differences and provide optimal care under current guidelines.

摘要-项目1 我们的创新研究方案集中在三个主要领域：1）初级预防; 2）筛查; 3)个性化医疗目前，美国和非洲的几项研究表明， 增加终生癌症风险，尤其是肺癌的风险。HIV-1感染者肺癌的病因学研究 感染的个体是未知的，但考虑到感染者的数量， HIV-1在这里，我们将调查肺癌的潜在危险因素，如地理空间居住，室内和 室外空气质量和吸烟行为，以更好地了解潜在的风险因素。这个一般 知识将有助于制定旨在减少有害暴露的初级预防方案， 降低肺癌的发病率。除了一级预防，我们的建议将评估临床特征， 与HIV-1感染者的肺癌风险和进展相关。这将提供机会 制定基于HIV-1感染状况的筛查方案，从而在早期阶段发现疾病， 降低整体死亡率。例如，结核病可能在胸部X光检查时表现为肺结节， 实际上，肺癌患者在肺癌诊断和挽救生命的治疗方面存在延迟。 了解这种关系将更好地使医生和健康提供者提供全面的 筛选最后，我们的提案将通过提供描述性的 HIV-1感染肺癌患者体细胞基因组突变分析这将提供基础 检查差异，并根据现行指南提供最佳护理。