Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania
乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系
基本信息
- 批准号:10267198
- 负责人:
- 金额:$ 10.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-21 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAfricaAfrica South of the SaharaAgeAirAreaBiological Specimen BanksCancer EtiologyCaringCessation of lifeClinicalClinical DistributionCohort AnalysisCollaborationsCross-Sectional StudiesDataDatabasesDiagnosisDiagnostic radiologic examinationDiseaseERBB2 geneEpidemiologistEpidemiologyEpidermal Growth Factor ReceptorEtiologyFemaleGenomicsGuidelinesHIVHIV InfectionsHIV-1Health PersonnelHistologyHistopathologyImageIncidenceIndividualInfectionKRAS2 geneKnowledgeLaboratoriesLifeLinkLogistic RegressionsLung noduleMalignant NeoplasmsMalignant neoplasm of lungMediatingModelingModificationMolecularMutationOutcomePatientsPersonsPhasePhysiciansPrevalencePrevention programPrimary PreventionROS1 geneRecurrenceReportingResearch ProposalsRiskRisk FactorsRoleSavingsSeriesSex DifferencesSmokingSmoking BehaviorSmoking StatusSomatic MutationStandardizationTanzaniaThoracic RadiographyTimeUgandaUniversitiesWomanWorld Health Organizationantiretroviral therapybasecancer riskcancer survivalcase controlclinical epidemiologydesigninnovationlifetime risklow and middle-income countriesmalemenmortalitymultidisciplinarypersonalized medicineresidencescreeningscreening programsexsurvival outcometumor progression
项目摘要
ABSTRACT – Project 1
The innovation of our research proposal focuses on three main areas: 1) primary prevention; 2) screening; and
3) personalized medicine. Currently, several studies in the US and Africa have demonstrated that HIV-1 infection
increases the risk of lifetime cancer risk, particularly lung cancer. The etiology of lung cancer among HIV-1
infected individuals is unknown, but of great importance given the number of individuals who live infected with
HIV-1. Here we will investigate potential risk factors for lung cancer such as geospatial residence, indoor and
outdoor air quality, and smoking behavior to better understand the underlying risk factors. This general
knowledge will serve to develop primary prevention programs designed to reduce adverse exposures thus
lowering the onset of lung cancer disease. Beyond primary prevention, our proposal will assess clinical features
associated with lung cancer risk and progression among those infected by HIV-1. This will provide the opportunity
to develop screening programs based on HIV-1 infection status thus detecting disease at an earlier phase and
decreasing the overall mortality. For example, TB may present as lung nodules during chest x-rays and patients
who actually have lung cancer have a delay in the diagnosis of lung cancer and life-saving treatments.
Understanding this relationship will better enable physicians and health providers to provide comprehensive
screening. Lastly, our proposal will expand the concept of personalized medicine by providing a descriptive
analysis of somatic genomic mutations among lung cancer cases infected with HIV-1. This will provide the basis
to examine for differences and provide optimal care under current guidelines.
摘要-项目1
我们的创新研究方案集中在三个主要领域:1)初级预防; 2)筛查;
3)个性化医疗目前,美国和非洲的几项研究表明,
增加终生癌症风险,尤其是肺癌的风险。HIV-1感染者肺癌的病因学研究
感染的个体是未知的,但考虑到感染者的数量,
HIV-1在这里,我们将调查肺癌的潜在危险因素,如地理空间居住,室内和
室外空气质量和吸烟行为,以更好地了解潜在的风险因素。这个一般
知识将有助于制定旨在减少有害暴露的初级预防方案,
降低肺癌的发病率。除了一级预防,我们的建议将评估临床特征,
与HIV-1感染者的肺癌风险和进展相关。这将提供机会
制定基于HIV-1感染状况的筛查方案,从而在早期阶段发现疾病,
降低整体死亡率。例如,结核病可能在胸部X光检查时表现为肺结节,
实际上,肺癌患者在肺癌诊断和挽救生命的治疗方面存在延迟。
了解这种关系将更好地使医生和健康提供者提供全面的
筛选最后,我们的提案将通过提供描述性的
HIV-1感染肺癌患者体细胞基因组突变分析这将提供基础
检查差异,并根据现行指南提供最佳护理。
项目成果
期刊论文数量(0)
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{{ truncateString('Simon Kasasa', 18)}}的其他基金
Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania
乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系
- 批准号:
10478908 - 财政年份:2020
- 资助金额:
$ 10.48万 - 项目类别:
Characterization of the clinical epidemiology of lung cancer and relationship to HIV-1 infection in Uganda and Tanzania
乌干达和坦桑尼亚肺癌临床流行病学特征及其与 HIV-1 感染的关系
- 批准号:
10084627 - 财政年份:2020
- 资助金额:
$ 10.48万 - 项目类别:
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