Oklahoma Rheumatic Disease Research Cores Center (Overall Application)

俄克拉荷马州风湿病研究核心中心（整体申请）

• 批准号: 10478206
• 负责人: JUDITH A JAMES
• 金额: $ 87.4万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478206
• 关键词: Aging; Applications Grants; Autoimmunity; Basic Science; Biological Assay; Biological Markers; Biomedical Engineering; Brain; Cells; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Collection; Communication; Complex; Connective Tissue Diseases; Consult; Cytometry; Data; Data Set; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease; Distant; Evaluation; Flow Cytometry; Foundations; Future; Genus Capra; Goals; Health; Human; Human Resources; Immune response; Immunologic Monitoring; Indigenous; Inflammatory; Informatics; Information Systems; Infrastructure; Institutes; Institution; International; Investigation; Investments; Leadership; Literature; Lupus; Manuscripts; Medicine; Mentors; Methodology; Mission; Modeling; Molecular; Monitor; NCI Scholars Program; National Institute of Allergy and Infectious Disease; Oklahoma; Pathogenesis; Pathologic; Patient Selection; Patient-Focused Outcomes; Patients; Phenotype; Pilot Projects; Precision therapeutics; Pregnancy; Preparation; Prevalence; Prevention; Prevention trial; Procedures; Prognosis; Proteomics; Public Health; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Sampling; Scientist; Seasons; Services; Sjogren' s Syndrome; Study Subject; Symptoms; System; Systemic Lupus Erythematosus; Technology; Testing; Training; Undifferentiated; United States National Institutes of Health; Work; assay development; autoimmune rheumatologic disease; base; biobank; career; clinical care; cost; data access; data warehouse; disease classification; experience; high dimensionality; inter-institutional; molecular phenotype; multidimensional data; multidisciplinary; patient subsets; phenotypic data; precision medicine; prognostic; programs; recruit; response; sample collection; systems research; therapeutic target; transcriptomics

Oklahoma Rheumatic Disease Research Cores Center: Overall Project Summary The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) unites 25 established Center Investigators, 22 junior center investigators (11 within and 11 outside Oklahoma) and a newly proposed Reichlin/Capra Scholar program to develop early-stage investigators with outstanding promise in rheumatic disease research. The mission of the ORDRCC is to optimize interactions between basic, clinical and analytic scientists focused on deciphering pathogenesis, prediction, prevention and precision therapeutic selection in rheumatic disease. As the foundation for this mission, the ORDRCC has developed some of the largest existing cross-sectional and longitudinal collections of SLE, Sjogren’s, and rheumatoid arthritis. With a CAP- certified Biorepository and electronic clinical research management system, the ORDRCC continues to expand these large, well-characterized collections and to build others in osteoarthritis, undifferentiated connective tissue disease and autoimmune rheumatic disease pregnancies. The ORDRCC-supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators and inter-institutional rheumatic disease collaborations, and have helped launch the independent careers of 27 former New Investigators. Without ORDRCC support, these collections would be unavailable, as would the basic infrastructure that enables the Biorepository to serve several NIH-sponsored and other investigator- initiated clinical trials at a fraction of the cost of a commercial biorepository. The Clinical Characterization and Biorepository Core (CCBC) which houses these collections, also provides clinical research units to aid in study recruitment, regulatory assistance for junior investigators and Scholars, and translational informatics to help visualize complex datasets of clinical and molecular data. The newly revised Human Phenotyping Core (HPC) empowers ORDRCC investigators to use the latest high-content phenotyping methodologies for precision medicine approaches by providing experienced technical personnel, proven standard operating procedures and training for sample preparation, assay development, data QC, and analytical assistance. The HPC helps ORDRCC investigators perform and analyze high-dimensional cytometry, single-cell transcriptomics and proteomics, high-content flow cytometry for functional immune response assays, molecular phenotyping by transcriptomics, and high-throughput testing of soluble biomarkers. Together the CCBC and HPC will integrate clinical and molecular information to identify molecularly homogeneous subsets of subjects for studies or trials. The Administrative Core serves as the central management and communication hub for the ORDRCC and coordinates a multi-disciplinary enrichment program, including a Rheumatic Disease Research Forum, a vibrant and successful Pilot Projects program, a new Proposal Development Core to assist investigators with developing robust manuscripts and competitive grant applications and a new Expanding Rheumatic Disease Research Colloquium to forge interactions between ORDRCC scientists and investigators from other fields.

俄克拉荷马州风湿病研究核心中心：总体项目摘要 俄克拉荷马州风湿病研究中心(ORDRCC)联合了25个已建立的中心 调查员，22名初级中心调查员(11名在俄克拉荷马州境内，11名在俄克拉荷马州以外)和一名新提出的 Reichlin/Capra学者计划开发在风湿病领域前景光明的早期研究人员 疾病研究。ORDRCC的使命是优化基础、临床和分析之间的互动 科学家们专注于破译疾病的发病机制、预测、预防和精确的治疗选择 风湿病。作为这项任务的基础，ORDRCC开发了一些最大的 现有的SLE、干燥和类风湿关节炎的横断面和纵向集合。使用CAP- 认证生物信息库和电子临床研究管理系统，ORDRCC继续扩大 这些大的，特征良好的集合和建立其他骨关节炎，未分化的结缔组织 组织病和自身免疫性风湿病妊娠。ORDRCC支持的集合和 生物信息库基础设施是许多成熟的风湿病研究人员和 风湿病机构间合作，并帮助启动了27个独立的职业生涯 前新调查员。如果没有ORDRCC支持，这些集合将不可用， 基本基础设施，使生物库能够为NIH赞助的几个研究人员和其他研究人员提供服务 启动了临床试验，成本只有商业生物仓库的一小部分。临床特征和临床表现 存储这些集合的生物信息库核心(CCBC)还提供临床研究单位来帮助研究 招聘、对初级调查人员和学者的监管援助以及翻译信息学 可视化临床和分子数据的复杂数据集。新修订的人类表型核心(HPC) 使ORDRCC调查人员能够使用最新的高含量表型方法来提高精确度 通过提供经验丰富的技术人员、经过验证的标准操作程序来实现医疗方法 以及关于样品准备、分析开发、数据质量控制和分析协助的培训。HPC帮助 ORDRCC调查人员执行和分析高维细胞术、单细胞转录和 蛋白质组学，用于功能免疫反应分析的高含量流式细胞术，分子表型 转录学和可溶生物标记物的高通量测试。CCBC和HPC将共同整合 临床和分子信息，以确定研究或试验对象的分子同质亚群。 管理核心是ORDRCC的中央管理和通信枢纽， 协调多学科丰富计划，包括风湿病研究论坛、 充满活力和成功的试点项目计划，一个新的提案开发核心，以帮助调查人员 发展强劲的稿件和竞争性的赠款申请与一种新的扩张性风湿病 研究座谈会，以促进ORDRCC科学家和其他领域的研究人员之间的互动。