Oklahoma Rheumatic Disease Research Cores Center (Overall Application)

俄克拉荷马州风湿病研究核心中心（整体申请）

• 批准号: 10478206
• 负责人: JUDITH A JAMES
• 金额: $ 87.4万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-07 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10478206
• 关键词: Aging; Applications Grants; Autoimmunity; Basic Science; Biological Assay; Biological Markers; Biomedical Engineering; Brain; Cells; Clinical; Clinical Management; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Collection; Communication; Complex; Connective Tissue Diseases; Consult; Cytometry; Data; Data Set; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease; Distant; Evaluation; Flow Cytometry; Foundations; Future; Genus Capra; Goals; Health; Human; Human Resources; Immune response; Immunologic Monitoring; Indigenous; Inflammatory; Informatics; Information Systems; Infrastructure; Institutes; Institution; International; Investigation; Investments; Leadership; Literature; Lupus; Manuscripts; Medicine; Mentors; Methodology; Mission; Modeling; Molecular; Monitor; NCI Scholars Program; National Institute of Allergy and Infectious Disease; Oklahoma; Pathogenesis; Pathologic; Patient Selection; Patient-Focused Outcomes; Patients; Phenotype; Pilot Projects; Precision therapeutics; Pregnancy; Preparation; Prevalence; Prevention; Prevention trial; Procedures; Prognosis; Proteomics; Public Health; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rheumatism; Rheumatoid Arthritis; Rheumatology; Sampling; Scientist; Seasons; Services; Sjogren' s Syndrome; Study Subject; Symptoms; System; Systemic Lupus Erythematosus; Technology; Testing; Training; Undifferentiated; United States National Institutes of Health; Work; assay development; autoimmune rheumatologic disease; base; biobank; career; clinical care; cost; data access; data warehouse; disease classification; experience; high dimensionality; inter-institutional; molecular phenotype; multidimensional data; multidisciplinary; patient subsets; phenotypic data; precision medicine; prognostic; programs; recruit; response; sample collection; systems research; therapeutic target; transcriptomics

Oklahoma Rheumatic Disease Research Cores Center: Overall Project Summary The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) unites 25 established Center Investigators, 22 junior center investigators (11 within and 11 outside Oklahoma) and a newly proposed Reichlin/Capra Scholar program to develop early-stage investigators with outstanding promise in rheumatic disease research. The mission of the ORDRCC is to optimize interactions between basic, clinical and analytic scientists focused on deciphering pathogenesis, prediction, prevention and precision therapeutic selection in rheumatic disease. As the foundation for this mission, the ORDRCC has developed some of the largest existing cross-sectional and longitudinal collections of SLE, Sjogren’s, and rheumatoid arthritis. With a CAP- certified Biorepository and electronic clinical research management system, the ORDRCC continues to expand these large, well-characterized collections and to build others in osteoarthritis, undifferentiated connective tissue disease and autoimmune rheumatic disease pregnancies. The ORDRCC-supported collections and biorepository infrastructure are critical resources for many established rheumatic disease investigators and inter-institutional rheumatic disease collaborations, and have helped launch the independent careers of 27 former New Investigators. Without ORDRCC support, these collections would be unavailable, as would the basic infrastructure that enables the Biorepository to serve several NIH-sponsored and other investigator- initiated clinical trials at a fraction of the cost of a commercial biorepository. The Clinical Characterization and Biorepository Core (CCBC) which houses these collections, also provides clinical research units to aid in study recruitment, regulatory assistance for junior investigators and Scholars, and translational informatics to help visualize complex datasets of clinical and molecular data. The newly revised Human Phenotyping Core (HPC) empowers ORDRCC investigators to use the latest high-content phenotyping methodologies for precision medicine approaches by providing experienced technical personnel, proven standard operating procedures and training for sample preparation, assay development, data QC, and analytical assistance. The HPC helps ORDRCC investigators perform and analyze high-dimensional cytometry, single-cell transcriptomics and proteomics, high-content flow cytometry for functional immune response assays, molecular phenotyping by transcriptomics, and high-throughput testing of soluble biomarkers. Together the CCBC and HPC will integrate clinical and molecular information to identify molecularly homogeneous subsets of subjects for studies or trials. The Administrative Core serves as the central management and communication hub for the ORDRCC and coordinates a multi-disciplinary enrichment program, including a Rheumatic Disease Research Forum, a vibrant and successful Pilot Projects program, a new Proposal Development Core to assist investigators with developing robust manuscripts and competitive grant applications and a new Expanding Rheumatic Disease Research Colloquium to forge interactions between ORDRCC scientists and investigators from other fields.

俄克拉荷马州风湿病研究核心中心：总体项目总结 俄克拉荷马州风湿性疾病研究核心中心（ORDRCC）联合了25个已建立的中心 研究人员，22名初级中心研究人员（11名在俄克拉荷马州内，11名在俄克拉荷马州外）和一名新提出的 Reichlin/Capra Scholar计划旨在培养在风湿性关节炎方面具有突出前景的早期研究者 疾病研究。该中心的使命是优化基础、临床和分析之间的相互作用 科学家们专注于破译发病机制，预测，预防和精确的治疗选择， 风湿病作为这一使命的基础，该中心开发了一些最大的 现有的SLE、干燥综合征和类风湿性关节炎的横断面和纵向收集。戴上帽子- 经过认证的生物储存库和电子临床研究管理系统， 这些大的，特征良好的集合，并建立其他骨关节炎，未分化结缔组织 组织疾病和自身免疫性风湿病妊娠。ORCCC支持的收藏品和 生物贮藏库基础设施是许多已建立的风湿病研究者的关键资源， 机构间风湿性疾病合作，并帮助推出了27个独立的职业生涯 前新调查员如果没有ORDRCC支持，这些集合将不可用， 基本的基础设施，使生物储存库能够为几个NIH赞助的和其他研究者服务， 开始了临床试验，成本仅为商业生物储存库的一小部分。临床表征和 生物库核心（CCBC）存放这些收藏品，还提供临床研究单位，以帮助研究 招聘，初级研究人员和学者的监管援助，以及翻译信息学，以帮助 可视化临床和分子数据的复杂数据集。新修订的人类表型核心（HPC） 使ORDRCC研究人员能够使用最新的高含量表型分析方法， 通过提供经验丰富的技术人员，经过验证的标准操作程序， 以及样品制备、测定开发、数据质量控制和分析协助方面的培训。HPC帮助 研究人员进行和分析了高维细胞计数，单细胞转录组学和 蛋白质组学，用于功能性免疫应答测定的高含量流式细胞术， 转录组学和可溶性生物标志物的高通量测试。CCBC和HPC将共同集成 临床和分子信息，以确定研究或试验的受试者的分子同质子集。 行政核心是区域减灾协调中心的中央管理和通信枢纽， 协调多学科的丰富计划，包括风湿病研究论坛， 充满活力和成功的试点项目计划，一个新的提案开发核心，以协助调查人员， 开发强大的手稿和有竞争力的赠款申请和一个新的扩大风湿性疾病 研究座谈会，以建立ORDRC科学家和其他领域的调查人员之间的互动。