Oklahoma Rheumatic Disease Research Cores Center (Overall Application)
俄克拉荷马州风湿病研究核心中心(整体申请)
基本信息
- 批准号:10478206
- 负责人:
- 金额:$ 87.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-07 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgingApplications GrantsAutoimmunityBasic ScienceBiological AssayBiological MarkersBiomedical EngineeringBrainCellsClinicalClinical ManagementClinical ResearchClinical TrialsClinical Trials DesignCollaborationsCollectionCommunicationComplexConnective Tissue DiseasesConsultCytometryDataData SetDegenerative polyarthritisDevelopmentDiagnosisDiagnosticDiseaseDistantEvaluationFlow CytometryFoundationsFutureGenus CapraGoalsHealthHumanHuman ResourcesImmune responseImmunologic MonitoringIndigenousInflammatoryInformaticsInformation SystemsInfrastructureInstitutesInstitutionInternationalInvestigationInvestmentsLeadershipLiteratureLupusManuscriptsMedicineMentorsMethodologyMissionModelingMolecularMonitorNCI Scholars ProgramNational Institute of Allergy and Infectious DiseaseOklahomaPathogenesisPathologicPatient SelectionPatient-Focused OutcomesPatientsPhenotypePilot ProjectsPrecision therapeuticsPregnancyPreparationPrevalencePreventionPrevention trialProceduresPrognosisProteomicsPublic HealthResearchResearch DesignResearch InfrastructureResearch PersonnelResourcesRheumatismRheumatoid ArthritisRheumatologySamplingScientistSeasonsServicesSjogren&aposs SyndromeStudy SubjectSymptomsSystemSystemic Lupus ErythematosusTechnologyTestingTrainingUndifferentiatedUnited States National Institutes of HealthWorkassay developmentautoimmune rheumatologic diseasebasebiobankcareerclinical carecostdata accessdata warehousedisease classificationexperiencehigh dimensionalityinter-institutionalmolecular phenotypemultidimensional datamultidisciplinarypatient subsetsphenotypic dataprecision medicineprognosticprogramsrecruitresponsesample collectionsystems researchtherapeutic targettranscriptomics
项目摘要
Oklahoma Rheumatic Disease Research Cores Center: Overall Project Summary
The Oklahoma Rheumatic Disease Research Cores Center (ORDRCC) unites 25 established Center
Investigators, 22 junior center investigators (11 within and 11 outside Oklahoma) and a newly proposed
Reichlin/Capra Scholar program to develop early-stage investigators with outstanding promise in rheumatic
disease research. The mission of the ORDRCC is to optimize interactions between basic, clinical and analytic
scientists focused on deciphering pathogenesis, prediction, prevention and precision therapeutic selection in
rheumatic disease. As the foundation for this mission, the ORDRCC has developed some of the largest
existing cross-sectional and longitudinal collections of SLE, Sjogren’s, and rheumatoid arthritis. With a CAP-
certified Biorepository and electronic clinical research management system, the ORDRCC continues to expand
these large, well-characterized collections and to build others in osteoarthritis, undifferentiated connective
tissue disease and autoimmune rheumatic disease pregnancies. The ORDRCC-supported collections and
biorepository infrastructure are critical resources for many established rheumatic disease investigators and
inter-institutional rheumatic disease collaborations, and have helped launch the independent careers of 27
former New Investigators. Without ORDRCC support, these collections would be unavailable, as would the
basic infrastructure that enables the Biorepository to serve several NIH-sponsored and other investigator-
initiated clinical trials at a fraction of the cost of a commercial biorepository. The Clinical Characterization and
Biorepository Core (CCBC) which houses these collections, also provides clinical research units to aid in study
recruitment, regulatory assistance for junior investigators and Scholars, and translational informatics to help
visualize complex datasets of clinical and molecular data. The newly revised Human Phenotyping Core (HPC)
empowers ORDRCC investigators to use the latest high-content phenotyping methodologies for precision
medicine approaches by providing experienced technical personnel, proven standard operating procedures
and training for sample preparation, assay development, data QC, and analytical assistance. The HPC helps
ORDRCC investigators perform and analyze high-dimensional cytometry, single-cell transcriptomics and
proteomics, high-content flow cytometry for functional immune response assays, molecular phenotyping by
transcriptomics, and high-throughput testing of soluble biomarkers. Together the CCBC and HPC will integrate
clinical and molecular information to identify molecularly homogeneous subsets of subjects for studies or trials.
The Administrative Core serves as the central management and communication hub for the ORDRCC and
coordinates a multi-disciplinary enrichment program, including a Rheumatic Disease Research Forum, a
vibrant and successful Pilot Projects program, a new Proposal Development Core to assist investigators with
developing robust manuscripts and competitive grant applications and a new Expanding Rheumatic Disease
Research Colloquium to forge interactions between ORDRCC scientists and investigators from other fields.
俄克拉何马州风湿病研究核心中心:总体项目总结
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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JUDITH A JAMES其他文献
JUDITH A JAMES的其他文献
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{{ truncateString('JUDITH A JAMES', 18)}}的其他基金
Autoimmune Drivers and Protectors Team Science (ADAPTS)
自身免疫驱动器和保护器团队科学 (ADAPTS)
- 批准号:
10657232 - 财政年份:2023
- 资助金额:
$ 87.4万 - 项目类别:
Environmental Influences Driving Autoimmunity and Autoimmune Disease in Tribal Members
环境影响导致部落成员发生自身免疫和自身免疫疾病
- 批准号:
10438444 - 财政年份:2022
- 资助金额:
$ 87.4万 - 项目类别:
Environmental Influences Driving Autoimmunity and Autoimmune Disease in Tribal Members
环境影响导致部落成员发生自身免疫和自身免疫疾病
- 批准号:
10707068 - 财政年份:2022
- 资助金额:
$ 87.4万 - 项目类别:
Oklahoma Shared Clinical and Translational Resources
俄克拉荷马州共享临床和转化资源
- 批准号:
10293114 - 财政年份:2021
- 资助金额:
$ 87.4万 - 项目类别:
Oklahoma ACE: Molecular Deconstruction of Autoimmune Disease to Aid Clinical Trial Success
俄克拉荷马州 ACE:自身免疫性疾病的分子解构有助于临床试验的成功
- 批准号:
10608163 - 财政年份:2019
- 资助金额:
$ 87.4万 - 项目类别:
Oklahoma ACE: Molecular Deconstruction of Autoimmune Disease to Aid Clinical Trial Success
俄克拉荷马州 ACE:自身免疫性疾病的分子解构有助于临床试验的成功
- 批准号:
9901415 - 财政年份:2019
- 资助金额:
$ 87.4万 - 项目类别:
Oklahoma ACE: Molecular Deconstruction of Autoimmune Disease to Aid Clinical Trial Success
俄克拉荷马州 ACE:自身免疫性疾病的分子解构有助于临床试验的成功
- 批准号:
10396550 - 财政年份:2019
- 资助金额:
$ 87.4万 - 项目类别:
Oklahoma ACE: Molecular Deconstruction of Autoimmune Disease to Aid Clinical Trial Success
俄克拉荷马州 ACE:自身免疫性疾病的分子解构有助于临床试验的成功
- 批准号:
10158411 - 财政年份:2019
- 资助金额:
$ 87.4万 - 项目类别:
Oklahoma Rheumatic Disease Research Cores Center
俄克拉荷马州风湿病研究核心中心
- 批准号:
10704387 - 财政年份:2018
- 资助金额:
$ 87.4万 - 项目类别:
Molecular Phenotyping of Autoimmunity in Tribal Members: Aiding Precision Medicine and Tribal Student Training
部落成员自身免疫的分子表型:协助精准医学和部落学生培训
- 批准号:
10005381 - 财政年份:2018
- 资助金额:
$ 87.4万 - 项目类别:














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