Oklahoma Shared Clinical and Translational Resources

俄克拉荷马州共享临床和转化资源

• 批准号: 10293114
• 负责人: JUDITH A JAMES
• 金额: $ 175.91万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293114
• 关键词: Address; Aging; American Indians; Americas; Area; Arthritis; Autoimmunity; Biometry; Caliber; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Center for Translational Science Activities; Cessation of life; Child Health; Childhood; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colon Carcinoma; Communication; Communities; Community Networks; Core Facility; County; Data; Development; Development Plans; Diabetes Mellitus; Discipline; Disease; Epidemiology; Eye; Female; Fostering; Foundations; Funding; Gap Junctions; Goals; Grant; Health; Health Priorities; Health Professional; Health system; Healthcare; Heart; High Prevalence; Immunization; Individual; Industry; Infrastructure; Institution; Investments; Leadership; Life Expectancy; Link; Longevity; Malignant Neoplasms; Measures; Medical; Mentors; Minority Groups; Mission; Modeling; Obesity; Oklahoma; Outcome; Patients; Population; Prevention; Primary Health Care; Privatization; Provider; Public Health; Registries; Research; Research Infrastructure; Research Personnel; Resources; Rural; Rural Minority; Rural Population; Sampling; Scientist; Secure; Smoking; Source; Students; Tobacco Use Cessation; Tobacco use; Training; Training and Infrastructure; Translational Research; Tribes; Underrepresented Minority; Underrepresented Populations; Underserved Population; United States National Institutes of Health; Vision; Visit; Work; Writing; biobank; cancer health disparity; career; catalyst; clinical data warehouse; clinical practice; community engaged research; data resource; data warehouse; disability; dissemination research; early childhood; education resources; health disparity; health equity; implementation research; improved; improved outcome; interest; malignant breast neoplasm; medical schools; mortality; novel; online resource; opioid abuse; opioid epidemic; patient registry; practice-based research network; premature; programs; recruit; repository; success; tool; training opportunity; translational research program; tribal Nation; tribal health; web portal

The pandemic caused by the novel coronavirus SARS-CoV-2 has resulted in substantial global morbidity and mortality including in Oklahoma and caused unprecedented interruptions in nearly all aspects of our lives. COVID-19 has demonstrated considerable disparities based on age and certain chronic illnesses as well as other social determinants of health. The population of the state of Oklahoma is at particular risk to SARS-CoV- 2 due to its large rural population, strained healthcare system, and poor overall health. Rural populations in general are medically underserved, older, and experience significant health disparities that overlap with those comorbid conditions that can result in severe cases or even death from the infection. The Oklahoma Shared Clinical and Translational Resources (OSCTR) and its long-standing community-engaged research programs and partnerships are perfectly positioned to contribute to the knowledge base necessary to improve the effectiveness of interventions to increase testing in underserved and vulnerable populations. We have designed an approach that allows us not only to collect essential information about community, provider, and patient-relevant impediments to SARS-CoV-2 diagnostic testing but also to meet the critical need to increase testing in our state as rapidly as possible. The Community-engaged Approaches to Testing in Community and Healthcare settings for Underserved Populations (CATCH-UP) program will involve both practice-based and community-based approaches to maximize the reach of the RADx-UP consortium, broaden the potential perspectives that could be captured, and compare the effectiveness of strategies. The interventions will be pragmatic to allow CATCH-UP to respond to changing attitudes, barriers, and environments as the pandemic progresses as well as expected technology developments to produce more effective viral testing that can provide rapid results to patients. The practice-based intervention will utilize our existing research infrastructure to assist 50 small primary care practices to implement guidelines-based testing and patient education about COVID-19 and risk mitigation strategies. Our community-based approach is designed to rapidly respond to community testing needs by deploying mobile testing sites that will provide operational support to increase the efficiency and the existing capacity for state-wide testing by Oklahoma’s public health authorities. Together, we estimate that the CATCH-UP program will result in at least 105,000 SARS-CoV-2 tests performed during the first year of implementation. A comprehensive, ongoing evaluation will be performed to analyze patient and provider attitudes, barriers and facilitators of viral testing, identified health disparities caused by COVID-19, effectiveness of the intervention in both settings, and to allow robust collaboration with other RADx-UP consortium sites.

由新型冠状病毒SARS-CoV-2引起的大流行导致了大量的全球发病率， 死亡率，包括在俄克拉荷马州，并造成前所未有的中断，几乎所有方面的我们的生活。 COVID-19已经显示出基于年龄和某些慢性疾病以及 健康的其他社会决定因素。俄克拉荷马州的人口特别容易感染SARS-CoV， 2由于其庞大的农村人口，紧张的医疗保健系统和整体健康状况不佳。农村人口 一般是医疗服务不足，年龄较大，并经历了重大的健康差距，与那些重叠 合并症，可能导致严重病例，甚至死亡的感染。俄克拉荷马州共享 临床和转化资源（OSCTR）及其长期的社区参与研究计划 和伙伴关系完全有能力为改善环境所需的知识基础作出贡献。 提高干预措施的有效性，以增加对服务不足和弱势群体的检测。我们有 设计了一种方法，使我们不仅可以收集有关社区，供应商的基本信息， SARS-CoV-2诊断检测的患者相关障碍，同时也满足增加 尽快在我国进行检测。社区参与的方法来测试在社区和 医疗保健设置为服务不足的人群（追赶）计划将涉及基于实践的， 以社区为基础的方法，以最大限度地扩大RADx-UP联盟的覆盖面，扩大潜力， 可以捕捉的观点，并比较战略的有效性。干预措施将是 务实地允许CATCH-UP对流行病不断变化的态度、障碍和环境做出反应， 以及预期的技术发展，以产生更有效的病毒检测， 为患者提供快速的结果。基于实践的干预将利用我们现有的研究基础设施 协助50个小型初级保健诊所实施基于指南的检测和患者教育， COVID-19及风险缓解策略。我们以社区为基础的方法旨在快速响应 通过部署移动的测试站点来满足社区测试需求，这些站点将提供运营支持， 效率和俄克拉荷马州公共卫生当局现有的全州范围内的测试能力。一起我们 据估计，追赶计划将导致至少105,000 SARS-CoV-2测试期间进行， 实施的第一年。将进行一项全面、持续的评价，以分析患者和 提供者的态度，病毒检测的障碍和促进者，确定了COVID-19造成的健康差异， 在这两种情况下干预的有效性，并允许与其他RADx-UP进行强有力的合作 财团网站。