Oklahoma Shared Clinical and Translational Resources

俄克拉荷马州共享临床和转化资源

• 批准号: 10293114
• 负责人: JUDITH A JAMES
• 金额: $ 175.91万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10293114
• 关键词: Address; Aging; American Indians; Americas; Area; Arthritis; Autoimmunity; Biometry; Caliber; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Center for Translational Science Activities; Cessation of life; Child Health; Childhood; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Colon Carcinoma; Communication; Communities; Community Networks; Core Facility; County; Data; Development; Development Plans; Diabetes Mellitus; Discipline; Disease; Epidemiology; Eye; Female; Fostering; Foundations; Funding; Gap Junctions; Goals; Grant; Health; Health Priorities; Health Professional; Health system; Healthcare; Heart; High Prevalence; Immunization; Individual; Industry; Infrastructure; Institution; Investments; Leadership; Life Expectancy; Link; Longevity; Malignant Neoplasms; Measures; Medical; Mentors; Minority Groups; Mission; Modeling; Obesity; Oklahoma; Outcome; Patients; Population; Prevention; Primary Health Care; Privatization; Provider; Public Health; Registries; Research; Research Infrastructure; Research Personnel; Resources; Rural; Rural Minority; Rural Population; Sampling; Scientist; Secure; Smoking; Source; Students; Tobacco Use Cessation; Tobacco use; Training; Training and Infrastructure; Translational Research; Tribes; Underrepresented Minority; Underrepresented Populations; Underserved Population; United States National Institutes of Health; Vision; Visit; Work; Writing; biobank; cancer health disparity; career; catalyst; clinical data warehouse; clinical practice; community engaged research; data resource; data warehouse; disability; dissemination research; early childhood; education resources; health disparity; health equity; implementation research; improved; improved outcome; interest; malignant breast neoplasm; medical schools; mortality; novel; online resource; opioid abuse; opioid epidemic; patient registry; practice-based research network; premature; programs; recruit; repository; success; tool; training opportunity; translational research program; tribal Nation; tribal health; web portal

The pandemic caused by the novel coronavirus SARS-CoV-2 has resulted in substantial global morbidity and mortality including in Oklahoma and caused unprecedented interruptions in nearly all aspects of our lives. COVID-19 has demonstrated considerable disparities based on age and certain chronic illnesses as well as other social determinants of health. The population of the state of Oklahoma is at particular risk to SARS-CoV- 2 due to its large rural population, strained healthcare system, and poor overall health. Rural populations in general are medically underserved, older, and experience significant health disparities that overlap with those comorbid conditions that can result in severe cases or even death from the infection. The Oklahoma Shared Clinical and Translational Resources (OSCTR) and its long-standing community-engaged research programs and partnerships are perfectly positioned to contribute to the knowledge base necessary to improve the effectiveness of interventions to increase testing in underserved and vulnerable populations. We have designed an approach that allows us not only to collect essential information about community, provider, and patient-relevant impediments to SARS-CoV-2 diagnostic testing but also to meet the critical need to increase testing in our state as rapidly as possible. The Community-engaged Approaches to Testing in Community and Healthcare settings for Underserved Populations (CATCH-UP) program will involve both practice-based and community-based approaches to maximize the reach of the RADx-UP consortium, broaden the potential perspectives that could be captured, and compare the effectiveness of strategies. The interventions will be pragmatic to allow CATCH-UP to respond to changing attitudes, barriers, and environments as the pandemic progresses as well as expected technology developments to produce more effective viral testing that can provide rapid results to patients. The practice-based intervention will utilize our existing research infrastructure to assist 50 small primary care practices to implement guidelines-based testing and patient education about COVID-19 and risk mitigation strategies. Our community-based approach is designed to rapidly respond to community testing needs by deploying mobile testing sites that will provide operational support to increase the efficiency and the existing capacity for state-wide testing by Oklahoma’s public health authorities. Together, we estimate that the CATCH-UP program will result in at least 105,000 SARS-CoV-2 tests performed during the first year of implementation. A comprehensive, ongoing evaluation will be performed to analyze patient and provider attitudes, barriers and facilitators of viral testing, identified health disparities caused by COVID-19, effectiveness of the intervention in both settings, and to allow robust collaboration with other RADx-UP consortium sites.

新型冠状病毒 SARS-CoV-2 引起的大流行已导致全球发病率大幅上升， 包括俄克拉荷马州在内的死亡率，并对我们生活的几乎所有方面造成了前所未有的干扰。 COVID-19 已表现出基于年龄和某些慢性疾病以及 其他健康的社会决定因素。俄克拉荷马州的人口尤其面临 SARS-CoV 的威胁 2 由于农村人口众多、医疗系统紧张、整体健康状况不佳。农村人口 普遍医疗服务不足、年龄较大，并且经历着与这些情况重叠的显着健康差异 可能导致严重病例甚至因感染而死亡的合并症。俄克拉荷马共享 临床和转化资源 (OSCTR) 及其长期社区参与的研究项目 和伙伴关系完全有能力为改善所需的知识库做出贡献 增加对服务不足和弱势群体的检测的干预措施的有效性。我们有 设计了一种方法，使我们不仅可以收集有关社区、提供者和 SARS-CoV-2 诊断检测中与患者相关的障碍，同时也满足增加增加检测的迫切需要 尽快在我们州进行测试。社区参与测试的方法和 服务不足人群的医疗保健设置 (CATCH-UP) 计划将涉及基于实践和 基于社区的方法，最大限度地扩大 RADx-UP 联盟的影响范围，扩大潜力 可以捕获的观点，并比较策略的有效性。干预措施将是 务实，让 CATCH-UP 能够应对疫情期间不断变化的态度、障碍和环境 进步以及预期的技术发展可以产生更有效的病毒检测 为患者提供快速结果。基于实践的干预将利用我们现有的研究基础设施 协助 50 个小型初级保健机构实施基于指南的测试和患者教育 COVID-19 和风险缓解策略。我们基于社区的方法旨在快速响应 通过部署移动测试站点来满足社区测试需求，该站点将提供运营支持以提高 俄克拉荷马州公共卫生当局在全州范围内进行检测的效率和现有能力。我们一起 据估计，CATCH-UP 计划将在该计划期间进行至少 105,000 次 SARS-CoV-2 检测 实施的第一年。将进行全面、持续的评估来分析患者和 提供者的态度、病毒检测的障碍和促进因素、确定的由 COVID-19 引起的健康差异、 两种情况下干预措施的有效性，并允许与其他 RADx-UP 进行强有力的合作 财团网站。