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Small Animal Imaging Shared Resource

小动物成像共享资源

基本信息

批准号：
10478037
负责人：
RALPH P. MASON
金额：
$ 9.4万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10478037
关键词：
Acetates American Anatomy Animal Experimentation Animal Housing Animals Area Award Biodistribution Budgets Cancer Biology Cancer Center Planning Grant Cancer Center Support Grant Chemicals Choline Clinic Clinical Trials Communication Companions Complement Comprehensive Cancer Center Consult Consultations Cyclotrons Data Development Doctor of Philosophy Drug Kinetics Drug Targeting Ensure Equipment Ethics Evaluation Functional disorder Funding Gastroenterology Genetic Engineering Goals Grant Image Imaging Device Imaging Techniques Imaging technology ImmunoPET Immunooncology Individual Infrastructure Intervention Investigation Isotope Labeling Isotopes Journals Label Laboratories Leadership Link Magnetic Resonance Imaging Malignant Neoplasms Medical center Metabolism Methods Misonidazole Multimodal Imaging NCI Center for Cancer Research National Cancer Institute Nature Neurosciences Optics PET/CT scan Peer Review Performance Prognostic Marker Publications Publishing Radiation Radiochemistry Radioisotopes Radiolabeled Reagent Research Research Personnel Research Project Grants Resource Sharing Resources Series Services Small Animal Imaging Shared Resource Societies Technology Testing The Sun Therapeutic Therapeutic antibodies Tracer Training Translational Research Translations Ultrasonography Visualization Work anatomic imaging animal imaging anticancer research base cellular imaging clinical investigation community center cost experience fluorodeoxyglucose germ free condition image guided imaging approach imaging biomarker imaging facilities imaging modality improved in vivo insight instrument instrumentation irradiation meetings member molecular imaging novel novel strategies novel therapeutic intervention novel therapeutics nuclear imaging optical imaging optoacoustic tomography outreach pre-clinical precision oncology programs receptor single photon emission computed tomography success symposium theranostics tool treatment response tumor tumor hypoxia ultrasound

项目摘要

The Small Animal Imaging Shared Resource (SAISR) at Simmons Comprehensive Cancer Center (SCCC) is a comprehensive small animal multimodality imaging resource that facilitates advances in the understanding of cancer biology and the development of novel therapeutics. The SAISR enables noninvasive assessment of tumor development, progression, and response to therapy based on multiple imaging technologies, including optical, ultrasound, photoacoustics, MRI, CT, SPECT, and PET/CT. In addition to anatomical visualization, the SAISR provides spatial and functional context for prognostic biomarkers and theranostic interventions. Under the leadership of Ralph P. Mason, PhD, the SAISR facilitates and integrates pathophysiology, metabolism, and receptor target identification with anatomical imaging. The SAISR provides SCCC investigators with assisted and unassisted usage of imaging technologies, consultations on optimal imaging approaches, and hands-on training in the use of imaging modalities. Since the last renewal, the SAISR has incorporated several new approaches in order to stay at the leading edge of technology. Important enhancements in infrastructure and capabilities include new photoacoustic tomography and access to short-lived isotopes generated by a new cyclotron that provides multiple tracers, including 18F-MISO, 11C-acetate, and choline, that can be observed with a new Mediso PET/CT scanner. There have also been substantial upgrades to the MRI facilities that significantly expand the new preclinical radiation services so that investigators can use MRI and image-guided irradiation inside a specific pathogen-free vivarium, complementing the existing instruments in conventional animal housing areas. These capabilities of the SAISR were utilized by 41 investigators across four SCCC research programs in 2019 and provided key data and insights to support the success of more than 30 peer-reviewed, funded research project grants and 119 peer-reviewed publications since 2014, including work published in high-impact journals such as Nature, Nature Communications, Nature Neurosciences, Journal of Clinical Investigation, Gastroenterology, and the Journal of the American Chemical Society. In summary, the SAISR advances, supports, and provides important cancer research imaging modalities to the SCCC community, enabling them to efficiently test new therapeutic strategies in vivo as well as facilitate companion studies in clinical trials.

西蒙斯综合癌症中心（SCCC）的小动物成像共享资源（SAISR）是一个一个全面的小动物多模态成像资源，促进了对癌症生物学和新疗法的发展。SAISR能够对肿瘤进行无创评估基于多种成像技术，包括光学，超声、光声、MRI、CT、SPECT和PET/CT。除了解剖可视化，SAISR 为预后生物标志物和治疗诊断干预提供空间和功能背景。下在Ralph P. Mason博士的领导下，SAISR促进并整合了病理生理学、代谢和受体靶点识别与解剖成像。SAISR为SCCC调查人员提供协助，和无辅助使用成像技术，最佳成像方法的咨询，使用成像模式的培训。自上次更新以来，SAISR已纳入几个新的为了保持技术的领先地位，我们采取了各种方法。基础设施的重大改进，能力包括新的光声层析成像和获得由新的回旋加速器，提供多种示踪剂，包括18F-MISO，11 C-乙酸盐和胆碱，可以用新的Mediso PET/CT扫描仪MRI设备也进行了大量升级，扩展新的临床前放射服务，以便研究人员可以使用MRI和图像引导照射在一个无特定病原体的动物饲养场内，补充了传统动物饲养中的现有仪器地区SAISR的这些功能被四个SCCC研究项目的41名研究人员使用在2019年，提供了关键数据和见解，以支持30多个同行评审，资助的成功自2014年以来，研究项目赠款和119篇同行评议的出版物，包括在高影响力期刊上发表的作品期刊如Nature、Nature Communications、Nature Neurosciences、Journal of Clinical Investigation，胃肠病学和美国化学学会杂志。总之，SAISR的进步，支持并为SCCC社区提供重要的癌症研究成像模式，使他们能够在体内有效地测试新的治疗策略，并促进临床试验中的伴随研究。