Small Animal Imaging Shared Resource

小动物成像共享资源

基本信息

  • 批准号:
    10478037
  • 负责人:
  • 金额:
    $ 9.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-09-01 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

The Small Animal Imaging Shared Resource (SAISR) at Simmons Comprehensive Cancer Center (SCCC) is a comprehensive small animal multimodality imaging resource that facilitates advances in the understanding of cancer biology and the development of novel therapeutics. The SAISR enables noninvasive assessment of tumor development, progression, and response to therapy based on multiple imaging technologies, including optical, ultrasound, photoacoustics, MRI, CT, SPECT, and PET/CT. In addition to anatomical visualization, the SAISR provides spatial and functional context for prognostic biomarkers and theranostic interventions. Under the leadership of Ralph P. Mason, PhD, the SAISR facilitates and integrates pathophysiology, metabolism, and receptor target identification with anatomical imaging. The SAISR provides SCCC investigators with assisted and unassisted usage of imaging technologies, consultations on optimal imaging approaches, and hands-on training in the use of imaging modalities. Since the last renewal, the SAISR has incorporated several new approaches in order to stay at the leading edge of technology. Important enhancements in infrastructure and capabilities include new photoacoustic tomography and access to short-lived isotopes generated by a new cyclotron that provides multiple tracers, including 18F-MISO, 11C-acetate, and choline, that can be observed with a new Mediso PET/CT scanner. There have also been substantial upgrades to the MRI facilities that significantly expand the new preclinical radiation services so that investigators can use MRI and image-guided irradiation inside a specific pathogen-free vivarium, complementing the existing instruments in conventional animal housing areas. These capabilities of the SAISR were utilized by 41 investigators across four SCCC research programs in 2019 and provided key data and insights to support the success of more than 30 peer-reviewed, funded research project grants and 119 peer-reviewed publications since 2014, including work published in high-impact journals such as Nature, Nature Communications, Nature Neurosciences, Journal of Clinical Investigation, Gastroenterology, and the Journal of the American Chemical Society. In summary, the SAISR advances, supports, and provides important cancer research imaging modalities to the SCCC community, enabling them to efficiently test new therapeutic strategies in vivo as well as facilitate companion studies in clinical trials.
西蒙斯综合癌症中心(SCCC)的小动物成像共享资源(SAISR)是一项综合性研究

项目成果

期刊论文数量(0)
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专利数量(0)

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RALPH P. MASON其他文献

RALPH P. MASON的其他文献

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{{ truncateString('RALPH P. MASON', 18)}}的其他基金

Novel nanoparticles to stimulate therapeutic angiogenesis in peripheral arterial disease
刺激外周动脉疾病治疗性血管生成的新型纳米颗粒
  • 批准号:
    10462909
  • 财政年份:
    2022
  • 资助金额:
    $ 9.4万
  • 项目类别:
Novel nanoparticles to stimulate therapeutic angiogenesis in peripheral arterial disease
刺激外周动脉疾病治疗性血管生成的新型纳米颗粒
  • 批准号:
    10756875
  • 财政年份:
    2022
  • 资助金额:
    $ 9.4万
  • 项目类别:
Novel nanoparticles to stimulate therapeutic angiogenesis in peripheral arterial disease
刺激外周动脉疾病治疗性血管生成的新型纳米颗粒
  • 批准号:
    10616740
  • 财政年份:
    2022
  • 资助金额:
    $ 9.4万
  • 项目类别:
Vascular image-guided optimization of response (VIGOR) to therapy in kidney cancer
血管图像引导肾癌治疗反应优化 (VIGOR)
  • 批准号:
    10646312
  • 财政年份:
    2020
  • 资助金额:
    $ 9.4万
  • 项目类别:
Vascular image-guided optimization of response (VIGOR) to therapy in kidney cancer
血管图像引导肾癌治疗反应优化 (VIGOR)
  • 批准号:
    10442463
  • 财政年份:
    2020
  • 资助金额:
    $ 9.4万
  • 项目类别:
Vascular image-guided optimization of response (VIGOR) to therapy in kidney cancer
血管图像引导肾癌治疗反应优化 (VIGOR)
  • 批准号:
    10058644
  • 财政年份:
    2020
  • 资助金额:
    $ 9.4万
  • 项目类别:
Vascular image-guided optimization of response (VIGOR) to therapy in kidney cancer
血管图像引导肾癌治疗反应优化 (VIGOR)
  • 批准号:
    10171568
  • 财政年份:
    2020
  • 资助金额:
    $ 9.4万
  • 项目类别:
PROGNOSTIC RADIOLOGY AND THE PATHOPHYSIOLOGY OF TUMORS
预后放射学和肿瘤病理生理学
  • 批准号:
    8363897
  • 财政年份:
    2011
  • 资助金额:
    $ 9.4万
  • 项目类别:
SMALL ANIMAL IMAGING RESEARCH PROGRAM
小动物影像研究计划
  • 批准号:
    8363912
  • 财政年份:
    2011
  • 资助金额:
    $ 9.4万
  • 项目类别:
Small Animal Imaging Shared Resource
小动物成像共享资源
  • 批准号:
    10170627
  • 财政年份:
    2010
  • 资助金额:
    $ 9.4万
  • 项目类别:

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