Small Animal Imaging Shared Resource

Harold C.西蒙斯癌症中心 小动物影像共享资源（转化研究资源） 项目总结/摘要 小动物成像资源促进小动物成像使用多种方式，包括深度 分辨或平面光学成像（荧光（FLI）、生物发光（BLI）和化学发光（CLI））， MRI、超声、PET/CT、SPECT/CT和平面动脉造影。经验丰富的调查员和技术人员 有能力进行成像和协助数据解释的人与资源有关， 提供咨询并协助分析研究报告。有动物处理的基础设施（例如， 麻醉、输注、监测生命体征）。这些高端成像仪器将超出预算 大多数研究团队的成像技术，如果没有资源，大多数研究人员将无法获得成像技术。 技术咨询委员会的资源领导人和成员可就以下问题向调查人员提供咨询意见： 实验计划（最佳实验方法，图像处理，和统计分析， 与机构动物护理和使用委员会以及环境健康和安全协调）， 开展调查（使用仪器和安排实验）、数据分析和验证 和数据存档。这些专家可以协助进行原理验证调查，例如脉冲编程 用于新型MRI实验、MR线圈的设计和采集或构建、 报道分子和/或基因、放射性标记方法和配体的合成。一旦实验 已制定了方案，将在收回成本的基础上进行例行调查， 专业的技术人员。在过去的一年里，资源支持了26名成员，所有成员都有同行- 审查了资金支持，包括25个NIH赠款（主要是R 01，但也有P01，U 01，P50）以及重要的 来自CPRIT（25笔赠款）、国防部（8笔赠款）和私人基金会的支持。26篇论文发表于 2013年，受益于资源的能力。

Harold C. Simmons Cancer Center Small Animal Imaging Shared Resource (Translational Research Resource) Project Summary/Abstract The Small Animal Imaging Resource facilitates small animal imaging using multiple modalities including depth resolved or planar optical imaging (fluorescence (FLI), bioluminescence (BLI) and chemiluminescence (CLI)), MRI, ultrasound, PET/CT, SPECT/CT and planar scintigraphy. Experienced investigators and technical staff capable of undertaking imaging and assisting in data interpretation are associated with the Resource and provide consultation and assist with analysis of studies. There is infrastructure for animal handling (e.g., anesthesia, infusion, monitoring vital signs). These high end imaging instruments would be beyond the budget of most research teams and without the Resource, imaging would be unavailable to most investigators. Resource leaders and members of the Technical Advisory Committee can advise investigators on experimental planning (optimal experimental approaches, image manipulation, and statistical analysis, coordinating with Institutional Animal Care and Use Committee, and Environmental Health and Safety), implementing investigations (access to instruments and scheduling experiments), data analysis and validation and data archiving. These experts can assist with proof of principle investigations, such as pulse programming and implementation for novel MRI experiments, design and acquisition or building of MR coils, choice of reporter molecules and /or genes, radiolabeling procedures and synthesis of ligands. Once experimental protocols have been established, routine investigations will be performed on a cost recovery basis by dedicated skilled technicians. During the past year the Resource supported 26 members, all with peer- reviewed funding support including 25 NIH grants (primarily R01, but also P01, U01, P50) as well as significant support from CPRIT (25 grants), DOD (8 grants) and private foundations. 26 new publications appeared during 2013 which benefited from the capabilities of the Resource.