A technology-based psychosocial intervention to support social engagement and well-being in adults aging with HIV

基于技术的社会心理干预，支持艾滋病毒感染者的社会参与和福祉

• 批准号: 10481052
• 负责人: SARA J CZAJA
• 金额: $ 25.43万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10481052
• 关键词: AIDS/HIV problem; Address; Adult; Affect; Age; Age-Years; Aging; Area; Behavior; Behavior Therapy; Biological; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Communities; Data; Development; Diagnosis; Early treatment; Education; Elderly; Engineering; Ensure; Focus Groups; Fostering; Funding; Goals; HIV; HIV Long-Term Survivors; Health; Health behavior; Home; Impaired cognition; Individual; Intervention; Intervention Studies; Kidney Diseases; Knowledge; Learning; Life Expectancy; Liver diseases; Loneliness; Long-Term Survivors; Malignant Neoplasms; Measures; Medical; Medicine; Mental Depression; Mental Health; NIH Office of AIDS Research; Outcome; Participant; Pattern; Personal Satisfaction; Persons; Phase; Pilot Projects; Population; Prevalence; Process; Psychosocial Influences; Public Health; Quality of life; Randomized; Reporting; Research; Research Personnel; Resources; Risk; Sample Size; Sampling; Services; Social Network; Social isolation; Social support; Stigmatization; Substance abuse problem; System; Tablets; Technology; Testing; Time; United States National Academy of Sciences; United States National Institutes of Health; Withdrawal; Work; aged; antiretroviral therapy; base; cohort; comorbidity; design; disparity reduction; efficacy trial; experience; health related quality of life; improved; improved outcome; indexing; innovative technologies; intervention program; mortality; multidisciplinary; multiple chronic conditions; phase 1 study; pilot trial; programs; psychosocial; recruit; resilience; social; social capital; social engagement; social stigma; systematic review; therapy development; usability; working group

Project Summary Older people with HIV (OPH) often live with significant mental health challenges such as social isolation, loneliness, and depression. Yet to date, there has been limited intervention research directed at psychosocial issues such as social isolation and loneliness among aging adults with HIV, especially long-term survivors, an area especially relevant given the COVID-19 pandemic and “stay in place” requirements. This proposed exploratory/development study addresses these issues and is responsive to NIH PAR-18-190 Multidisciplinary Studies of HIV and Aging. Consistent with OAR emphasis on improving outcomes through Cross-Cutting research to address HIV-associated comorbidities and complications, the study objectives are to develop and evaluate a technology-based psychosocial intervention program designed to: enhance social engagement and support, resource access and education; reduce loneliness; and improve well-being among older adults with HIV who are long-term survivors (diagnosed with HIV ≥ 20 years). The program, Connecting Older Positive People to Enhance Health and Resilience (COPPEhR), will build on the PRISM tablet platform [13] and the programs and services available at the Center for Special Studies (CSS) at Weill Cornell Medicine (WCM) (see preliminary studies). Phase 1 of the study will involve developing and tailoring the system for this understudied population, focus groups, and usability testing with a small sample of aging adults with HIV, and Phase 2 will involve a two-group pilot efficacy trial (akin to an NIH Stage 1b trial). The COPPEhR intervention will be compared to a tablet-only control condition (TCC). Sixty-eight adults aged 50+, stratified by age, with HIV who are long-term survivors (diagnosed with HIV ≥ 20 years) will be recruited and randomly assigned 1:1 to the COPPEhR or TCC conditions. The intervention duration will be six months. Outcomes will include measures of depression, loneliness, social support, changes in social network, quality of life, and indices of health. Assessments will be conducted at baseline and 3 & 6-months post-randomization. We will also assess the feasibility, usefulness, and usability of the COPPEhR system and collect real time data on system use. The specific aims of this developmental project are to: 1) Evaluate the feasibility, usefulness, and usability of a state-of-the art technology-based multicomponent COPPEhR intervention for aging adults with HIV; and, 2) Obtain preliminary information on the potential efficacy of the COPPEhR program in terms of enhancing social engagement, well-being, and resource access, and reducing loneliness among older adults with HIV. The overall goal of the research is to support the development of an efficacious technology-based intervention for OPH that can be evaluated in a larger scale trial and be delivered to diverse older adults in a variety of community and residential settings.

项目摘要 老年艾滋病毒感染者（OPH）往往面临严重的心理健康挑战，如社会孤立， 孤独和抑郁然而，迄今为止，针对心理社会的干预研究有限。 艾滋病毒感染者，特别是长期幸存者的社会孤立和孤独等问题， 鉴于COVID-19疫情和“原地不动”的要求，这一领域尤其相关。这一拟议 探索性/开发性研究解决了这些问题，并响应了NIH PAR-18 - 190多学科 艾滋病毒和衰老的研究。与OAR强调的通过跨领域改进成果相一致 研究，以解决艾滋病毒相关的合并症和并发症，研究的目的是开发和 评估基于技术的心理社会干预计划，旨在：加强社会参与， 支持、资源获取和教育;减少孤独感;改善老年人的福祉， HIV长期存活者（诊断为HIV ≥ 20年）。该计划，连接老年人积极 人们增强健康和复原力（COPPEhR），将建立在PRISM平板电脑平台[13]和 项目和服务可在特殊研究中心（CSS）在威尔康奈尔医学（WCM）（见 初步研究）。该研究的第一阶段将涉及开发和定制该系统， 人口，焦点小组和可用性测试与艾滋病毒感染的老年人的小样本，第2阶段将 涉及两组试点疗效试验（类似于NIH Stage 1b试验）。COPPEhR的干预将是 与仅平板电脑对照条件（TCC）相比。68名50岁以上的成年人，按年龄分层， 将招募长期存活者（诊断为HIV感染≥ 20年），并按1：1的比例随机分配至 COPPEhR或TCC条件。干预持续时间为6个月。成果将包括以下措施： 抑郁、孤独、社会支持、社会网络变化、生活质量和健康指数。 将在基线和随机化后3个月和6个月进行评估。我们亦会评估 COPPEhR系统的可行性、有用性和可用性，并收集系统使用的真实的时间数据。的 这个开发项目的具体目标是：1）评估的可行性，有用性和可用性， 对感染艾滋病毒的老年人进行基于最新技术的多组分COPPEhR干预;以及2） 获得关于COPPEhR计划在提高 社会参与、福祉和资源获取，并减少艾滋病毒感染者的孤独感。 研究的总体目标是支持开发有效的基于技术的干预措施 对于OPH，可以在更大规模的试验中进行评估，并以各种方式提供给不同的老年人， 社区和住宅环境。