A technology-based psychosocial intervention to support social engagement and well-being in adults aging with HIV

基于技术的社会心理干预，支持艾滋病毒感染者的社会参与和福祉

• 批准号: 10481052
• 负责人: SARA J CZAJA
• 金额: $ 25.43万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10481052
• 关键词: AIDS/HIV problem; Address; Adult; Affect; Age; Age-Years; Aging; Area; Behavior; Behavior Therapy; Biological; COVID-19; COVID-19 pandemic; Cardiovascular Diseases; Communities; Data; Development; Diagnosis; Early treatment; Education; Elderly; Engineering; Ensure; Focus Groups; Fostering; Funding; Goals; HIV; HIV Long-Term Survivors; Health; Health behavior; Home; Impaired cognition; Individual; Intervention; Intervention Studies; Kidney Diseases; Knowledge; Learning; Life Expectancy; Liver diseases; Loneliness; Long-Term Survivors; Malignant Neoplasms; Measures; Medical; Medicine; Mental Depression; Mental Health; NIH Office of AIDS Research; Outcome; Participant; Pattern; Personal Satisfaction; Persons; Phase; Pilot Projects; Population; Prevalence; Process; Psychosocial Influences; Public Health; Quality of life; Randomized; Reporting; Research; Research Personnel; Resources; Risk; Sample Size; Sampling; Services; Social Network; Social isolation; Social support; Stigmatization; Substance abuse problem; System; Tablets; Technology; Testing; Time; United States National Academy of Sciences; United States National Institutes of Health; Withdrawal; Work; aged; antiretroviral therapy; base; cohort; comorbidity; design; disparity reduction; efficacy trial; experience; health related quality of life; improved; improved outcome; indexing; innovative technologies; intervention program; mortality; multidisciplinary; multiple chronic conditions; phase 1 study; pilot trial; programs; psychosocial; recruit; resilience; social; social capital; social engagement; social stigma; systematic review; therapy development; usability; working group

Project Summary Older people with HIV (OPH) often live with significant mental health challenges such as social isolation, loneliness, and depression. Yet to date, there has been limited intervention research directed at psychosocial issues such as social isolation and loneliness among aging adults with HIV, especially long-term survivors, an area especially relevant given the COVID-19 pandemic and “stay in place” requirements. This proposed exploratory/development study addresses these issues and is responsive to NIH PAR-18-190 Multidisciplinary Studies of HIV and Aging. Consistent with OAR emphasis on improving outcomes through Cross-Cutting research to address HIV-associated comorbidities and complications, the study objectives are to develop and evaluate a technology-based psychosocial intervention program designed to: enhance social engagement and support, resource access and education; reduce loneliness; and improve well-being among older adults with HIV who are long-term survivors (diagnosed with HIV ≥ 20 years). The program, Connecting Older Positive People to Enhance Health and Resilience (COPPEhR), will build on the PRISM tablet platform [13] and the programs and services available at the Center for Special Studies (CSS) at Weill Cornell Medicine (WCM) (see preliminary studies). Phase 1 of the study will involve developing and tailoring the system for this understudied population, focus groups, and usability testing with a small sample of aging adults with HIV, and Phase 2 will involve a two-group pilot efficacy trial (akin to an NIH Stage 1b trial). The COPPEhR intervention will be compared to a tablet-only control condition (TCC). Sixty-eight adults aged 50+, stratified by age, with HIV who are long-term survivors (diagnosed with HIV ≥ 20 years) will be recruited and randomly assigned 1:1 to the COPPEhR or TCC conditions. The intervention duration will be six months. Outcomes will include measures of depression, loneliness, social support, changes in social network, quality of life, and indices of health. Assessments will be conducted at baseline and 3 & 6-months post-randomization. We will also assess the feasibility, usefulness, and usability of the COPPEhR system and collect real time data on system use. The specific aims of this developmental project are to: 1) Evaluate the feasibility, usefulness, and usability of a state-of-the art technology-based multicomponent COPPEhR intervention for aging adults with HIV; and, 2) Obtain preliminary information on the potential efficacy of the COPPEhR program in terms of enhancing social engagement, well-being, and resource access, and reducing loneliness among older adults with HIV. The overall goal of the research is to support the development of an efficacious technology-based intervention for OPH that can be evaluated in a larger scale trial and be delivered to diverse older adults in a variety of community and residential settings.

项目摘要 艾滋病毒（OPH）的老年人经常受到重大心理健康挑战，例如社会隔离， 孤独和沮丧。迄今为止，针对社会心理的干预研究有限 艾滋病毒衰老的成年人，尤其是长期生存的衰老成年人中的社会隔离和孤独等问题 鉴于COVID-19的大流行和“留在原位”的要求，区域特别相关。这提出了 探索/发展研究解决了这些问题，并对NIH PAR-18-190响应多学科 艾滋病毒和衰老的研究。与OAR强调通过横切改善结果一致 为解决与艾滋病毒相关的合并症和并发症的研究，研究目标是发展和 评估旨在：增强社会参与和的基于技术的社会心理干预计划 支持，资源访问和教育；减少孤独感；并改善老年人的幸福感 长期生存的HIV（被诊断为HIV≥20年）。该程序，连接较旧的积极 人们增强健康和弹性（COPPEHR）的人将在Prism平板电脑平台[13]和 Weill Cornell Medicine（WCM）的特殊研究中心（CSS）提供的计划和服务（请参阅 初步研究）。研究的第一阶段将涉及开发和调整系统以进行这种理解 人口，焦点组和可用性测试与艾滋病毒衰老的成年人相少，第二阶段将 涉及两组试验效率试验（类似于NIH阶段1B试验）。 COPPEHR干预将是 与仅平板电脑的控制条件（TCC）相比。六十八名年龄在50岁以上的成年人，按年龄分层，艾滋病毒 将招募长期生存（被诊断为HIV≥20年），并随机分配给1：1 COPPEHR或TCC条件。干预持续时间为六个月。结果将包括 抑郁，孤独，社会支持，社交网络的变化，生活质量和健康指标。 评估将在基线和随机后3个月和6个月进行。我们还将评估 COPPEHR系统的可行性，有用性和可用性，并收集有关系统使用的实时数据。 该发展项目的具体目的是：1）评估一个的可行性，有用性和可用性 针对艾滋病毒衰老的成年人的最先进的基于技术的多组分COPPEHR干预； 2） 在增强方面获得有关COPPEHR计划潜在效率的初步信息 社交参与，福祉和资源获取，并减少艾滋病毒老年人的孤独感。 该研究的总体目标是支持开发有效的基于技术的干预措施 对于可以在大规模试验中进行评估的OPH，并将其交付给潜水员的老年人 社区和居民设置。