Timing of prenatal stress and early markers of child psychopathology

产前应激的发生时间和儿童精神病理学的早期标志

• 批准号: 10480751
• 负责人: Gloria Anne Bogat
• 金额: $ 62.21万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10480751
• 关键词: 4 year old; Address; Adolescent; Adult; Affect; Age; Behavioral; Brain; Child; Child Behavior; Child Development; Child Rearing; Childhood; Chronic; Communities; Coping Skills; Data; Data Collection; Development; Early Diagnosis; Environment; Environmental Risk Factor; Family; Funding; Goals; Grain; Grant; Healthcare; Impulsivity; Individual Differences; Infant; Informal Social Control; Intervention; Knowledge; Laboratories; Lead; Life; Life Stress; Literature; Machine Learning; Measures; Mediating; Mental Health; Mental disorders; Methods; Mothers; National Institute of Child Health and Human Development; Outcome; Physiological; Postpartum Period; Poverty; Predisposition; Pregnancy; Preschool Child; Problem behavior; Psychopathology; Public Health; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Salivary; Sinus Arrhythmia; Stress; System; Teratogens; Testing; Time; United States National Institutes of Health; Woman; base; behavior influence; behavior observation; biobehavior; boys; cohort; critical period; early childhood; executive function; externalizing behavior; fetal; girls; innovation; intimate partner violence; maternal stress; negative affect; neurobehavioral; novel; postnatal; prenatal; prenatal stress; prevent; preventive intervention; prospective; psychologic; relating to nervous system; resilience; respiratory; sex; stress reactivity; stressor; virtual

PROJECT SUMMARY Psychopathology is a very serious public health burden that not only affects adults, but also many children and adolescents. To better understand this devastating problem, the scientific community has focused its efforts on pinpointing the earliest developmental origins of psychopathology. A considerable literature now implicates prenatal stress as a critical determinant of poor psychological functioning in childhood and beyond. However, knowledge about whether the timing of prenatal stress differentially influences the development of child psychopathology is virtually unknown. Gaining such knowledge is the long-term goal of our research. This proposed project “piggybacks” on our current RO1-funded project (NICHD grant # R01HD085990) that is following a cohort of 335 women oversampled for life stress, with data collection starting at pregnancy week 15 until 6 months postpartum. We are conducting a granular assessment of pregnancy stress (measured weekly by maternal report) with the goal of understanding critical periods during fetal life when stress derails later infant behavioral and physiological stress responsivity. The overall objective of this new RO1 project is to follow this cohort into the child's preschool years. Specifically, in Aim 1 we will determine how the differential timing of prenatal stress influences behavior problems and psychopathology measured at age 4, how differences in self-regulation (an important precursor of mental health functioning) mediates the relationship between prenatal stress and psychopathology at age 4, and how these relationships differ between boys and girls. Aim 2 will test a host of postnatal risk factors (e.g., poor maternal mental health, poverty, intimate partner violence) and resilience factors (e.g., sensitive parenting, coping skills) as moderators of the effects of timing of prenatal stress on behavior problems and psychopathology at age 4. Importantly and uniquely, postnatal stress (mother and child) is assessed also in a fine-grained manner by every 3 month assessments from age 6 mos to 4 years. Finally, in Aim 3 we will use an exploratory statistical approach, machine learning, to detect which relatively small epochs of stress in postnatal life (measured every 3 months) interact with small epochs of prenatal stress to maximally influence child behavior problems and psychopathology. This project is innovative in its highly multimethod approach (e.g., behavioral observation, salivary analytes, laboratory tasks), its granular assessment of chronic and episodic prenatal and postnatal stressors, and the novel statistical approaches used to determine which epochs of stress are most relevant for psychopathology. This highly significant research will be the first longitudinal, prospective, multi-method study of how differential timing of prenatal stress influences the development of psychopathology, as mediated by child self-regulation and moderated by postnatal environmental factors. Thus, this study is critical for understanding how early child development sets the stage for psychopathology and will lead to increased understanding of the developmental epochs to be targeted for preventative interventions.

项目摘要 精神病理学是一个非常严重的公共卫生负担，不仅影响成年人，而且影响许多儿童， 青少年。为了更好地理解这个毁灭性的问题，科学界将其努力集中在 指出了精神病理学最早的发展起源大量文献表明 产前压力是儿童期及以后心理功能不良的关键决定因素。然而，在这方面， 了解产前压力的时间是否对儿童的发育有不同的影响， 精神病理学几乎是未知的。获得这些知识是我们研究的长期目标。这 建议的项目“搭载”我们目前的RO1资助的项目（NICHD赠款# R01HD085990），即 对335名因生活压力而过度抽样的妇女进行队列研究，从怀孕第15周开始收集数据 直到产后6个月。我们正在进行妊娠压力的粒度评估（每周测量一次 通过母亲的报告），目的是了解胎儿生命中的关键时期，当压力脱轨后 婴儿行为和生理应激反应。这个新的RO1项目的总体目标是 跟随这一群人直到孩子的学龄前。具体来说，在目标1中，我们将确定 产前压力的时间影响行为问题和4岁时测量的精神病理学， 自我调节（心理健康功能的重要前体）的差异介导了这种关系 产前压力和4岁时的精神病理学之间的关系，以及这些关系在男孩和 姑娘们目标2将测试一系列产后风险因素（例如，产妇心理健康差，贫穷，亲密伴侣 暴力）和复原力因素（例如，敏感的父母，应对技能）作为调节剂的影响的时间， 4岁时行为问题和精神病理学的产前压力。重要而独特的是，产后压力 （母亲和儿童）也以细粒度的方式进行评估，从6岁起每3个月进行一次评估。 到4年。最后，在目标3中，我们将使用一种探索性的统计方法，机器学习，来检测 出生后生活中相对较小的压力时期（每3个月测量一次）与出生后生活中相对较小的压力时期相互作用。 产前压力最大限度地影响儿童行为问题和精神病理学。这个项目是 在其高度多方法的方法中具有创新性（例如，行为观察，唾液分析物，实验室 任务），其慢性和偶发性产前和产后压力的颗粒评估，以及新的 用于确定哪些压力时期与精神病理学最相关的统计方法。这 高度重要的研究将是第一个纵向，前瞻性，多方法研究如何区分 产前压力的时间影响心理病理学的发展，通过儿童自我调节来介导 并受产后环境因素的调节。因此，这项研究对于了解早期儿童 发展为精神病理学奠定了基础，并将导致对精神病理学的理解增加。 预防性干预的目标是发展时期。