Fatty acid supplements alter biological signatures in children with Autism Spectrum Disorder
脂肪酸补充剂改变自闭症谱系障碍儿童的生物特征
基本信息
- 批准号:10480779
- 负责人:
- 金额:$ 40.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Adverse eventAffectAgeAnti-Inflammatory AgentsBehavior DisordersBiologicalBiological AvailabilityChildClinicalConflict (Psychology)ConsumptionDataDiagnosisDocosahexaenoic AcidsDocosahexaenoic acid supplementationDoseEicosapentaenoic AcidErythrocytesFamilyFatty AcidsFish OilsFormulationFoundationsFutureGoalsInflammationInfrastructureInterferon Type IIInterleukin-1 betaInterleukin-2Lifestyle-related conditionNatural ProductsObesityOmega-3 Fatty AcidsOutcomeParentsParticipantPathway interactionsPatientsPersonal SatisfactionPharmaceutical PreparationsPhasePhysiologicalPlant ExtractsPlasmaPopulationPropertyPsyche structurePublishingQuality of lifeRandomizedReportingResearchResearch PersonnelSafetySamplingSpecific qualifier valueSupplementationSymptomsTestingVariantVitaminsWeightautism spectrum disorderautistic childrenbaseborage oilclinical research siteclinically significantcomorbiditydesigndietary supplementsdosageeffective therapyefficacy trialevidence baseexternalizing behaviorfatty acid supplementationgamma-Linolenic Acidgastrointestinalinflammatory markerphysical symptomprimary endpointrecruitstemsymptomatic improvement
项目摘要
ABSTRACT
Fatty acid supplements are among the most popular complementary products consumed by children with Autism Spectrum Disorder (ASD), driven by anecdotal evidence of benefit and a few small RCTs that demonstrated improvements in externalizing behaviors. Because no approved drugs exist to treat the core symptoms of ASD, well-intentioned parents are reaching for any product that may help their child. The implications are that fatty acid supplements are given to children without any evidence base as to their function, mechanism of action, effective dose, or benefits versus harms. Over-the-counter (OTC) fatty acid supplements are plentiful and consist of varying fatty acid compositions and often contain other ingredients. Recent evidence from our group and others suggest a combination of fish and borage oils providing supplementation of DHA, EPA and GLA (“Omega 3-6”) is particularly promising compared to other formulations. A critical need exists to evaluate Omega 3-6 for optimal dosing and changes in a physiologically relevant biological signature related to ASD symptoms, before a rigorous, full-scale efficacy trial can be launched. Our objective is to evaluate the effects of higher doses of Omega 3-6 on pre-specified biological signatures Our overall hypothesis is that optimal dosing of Omega 3-6 will alter biological signatures in a manner that correlates with improvements in ASD-related behaviors. The R61 phase of this proposal will test the hypothesis that Omega 3-6 will produce a clinically-significant reduction (improvement) in one or more the inflammatory markers IL-1β, IL-2, and IFNγ and our higher doses will demonstrate bioavailability, safety, and tolerability. The R33 phase of this proposal will test the hypothesis that the impact on biological signatures correlates with Omega 3-6 dose, can be replicated in a new sample of patients, and the change in key inflammatory marker(s) are correlated with core ASD symptoms after supplementation. Upon completion of this proposed 2-phase project, we expect to have identified an optimal dosing range for which Omega 3-6 exerts its effect on inflammation and, subsequently, on ASD symptoms in children. Such results are expected to have an important positive impact by laying the necessary groundwork for a full-scale efficacy trial to evaluate the effect of Omega 3-6 on ASD symptom improvement.
摘要
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder.
- DOI:10.1007/s10803-021-05396-9
- 发表时间:2022-12
- 期刊:
- 影响因子:3.9
- 作者:Keim, Sarah A.;Jude, Abigail;Smith, Katie;Khan, Aiman Q.;Coury, Daniel L.;Rausch, Joseph;Udaipuria, Shivika;Norris, Megan;Bartram, Lindsay R.;Narayanan, Anita R.;Rogers, Lynette K.
- 通讯作者:Rogers, Lynette K.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sarah Keim其他文献
Sarah Keim的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sarah Keim', 18)}}的其他基金
Environmental Influences on Child Health Outcomes (ECHO) and Pregnancy in Ohio
俄亥俄州环境对儿童健康结果 (ECHO) 和怀孕的影响
- 批准号:
10746498 - 财政年份:2023
- 资助金额:
$ 40.05万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10226056 - 财政年份:2020
- 资助金额:
$ 40.05万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10650351 - 财政年份:2020
- 资助金额:
$ 40.05万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm - Administrative Supplement
学步期补充 DHA 对早产儿的长期影响和安全性 - 行政补充
- 批准号:
10727669 - 财政年份:2020
- 资助金额:
$ 40.05万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10012322 - 财政年份:2020
- 资助金额:
$ 40.05万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10443726 - 财政年份:2020
- 资助金额:
$ 40.05万 - 项目类别:
Fatty acid supplements alter biological signatures in children with Autism Spectrum Disorder
脂肪酸补充剂改变自闭症谱系障碍儿童的生物特征
- 批准号:
10222888 - 财政年份:2017
- 资助金额:
$ 40.05万 - 项目类别:
Fatty acid supplements alter biological signatures in children with Autism Spectrum Disorder
脂肪酸补充剂改变自闭症谱系障碍儿童的生物特征
- 批准号:
10266170 - 财政年份:2017
- 资助金额:
$ 40.05万 - 项目类别:
The Development of Early Childhood Obesity in Children Born Preterm
早产儿早期肥胖的发展
- 批准号:
9112267 - 财政年份:2016
- 资助金额:
$ 40.05万 - 项目类别:
Development and Evaluation of New Breastfeeding Questions Applicable to Multiple National Surveys
适用于多项全国调查的新母乳喂养问题的开发和评估
- 批准号:
9159393 - 财政年份:2016
- 资助金额:
$ 40.05万 - 项目类别:
相似海外基金
Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
- 批准号:
495182 - 财政年份:2023
- 资助金额:
$ 40.05万 - 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
- 批准号:
2601817 - 财政年份:2021
- 资助金额:
$ 40.05万 - 项目类别:
Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
- 批准号:
2029039 - 财政年份:2020
- 资助金额:
$ 40.05万 - 项目类别:
Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
- 批准号:
9888417 - 财政年份:2019
- 资助金额:
$ 40.05万 - 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
- 批准号:
17K11318 - 财政年份:2017
- 资助金额:
$ 40.05万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9320090 - 财政年份:2017
- 资助金额:
$ 40.05万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
10166936 - 财政年份:2017
- 资助金额:
$ 40.05万 - 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
- 批准号:
9761593 - 财政年份:2017
- 资助金额:
$ 40.05万 - 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
- 批准号:
BB/M50306X/1 - 财政年份:2014
- 资助金额:
$ 40.05万 - 项目类别:
Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
- 批准号:
288272 - 财政年份:2013
- 资助金额:
$ 40.05万 - 项目类别:
Miscellaneous Programs














{{item.name}}会员




