Environmental Influences on Child Health Outcomes (ECHO) and Pregnancy in Ohio
俄亥俄州环境对儿童健康结果 (ECHO) 和怀孕的影响
基本信息
- 批准号:10746498
- 负责人:
- 金额:$ 132.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2025-05-31
- 项目状态:未结题
- 来源:
- 关键词:21 year oldAdultAmerican Heart AssociationAnthropometryAppalachian RegionAreaBehaviorBirthBlack raceCaringChildChild BehaviorChild HealthChildhoodClinicalCollaborationsCommunitiesComplementConceptionsContinuous Glucose MonitorDataData CollectionData ElementDevelopmentDimensionsDisparateEmotionalEnrollmentEnsureEnvironmental ExposureEthnic OriginGenerationsGenesGeneticGenomic approachGoalsHealthHealth systemImmigrantImpairmentIndividualInequityInfant HealthInvestigationKnowledgeLeadershipLifeLife StyleLong-Term EffectsLongitudinal StudiesMaternal ExposureMaternal and Child HealthMeasuresMediatingMediationMediatorMedical centerMethodsMolecularNeonatalNeurodevelopmental ImpairmentNot Hispanic or LatinoOhioOutcomeParentsParticipantPathway interactionsPatientsPatternPediatric HospitalsPennsylvaniaPerinatalPersonal SatisfactionPopulationPopulation HeterogeneityPostpartum PeriodPovertyPregnancyPregnancy OutcomeProtocols documentationRefugeesResearchResearch PersonnelRoleRuralSecureSiteSurveysTechniquesTimeUnderserved PopulationUnited States National Institutes of HealthUniversitiesWest VirginiaWorkcardiovascular healthcohortemerging adultepidemiologic dataethnic minority populationexperiencefollow-uphealth datahigh riskimprovedinnovationmaternal riskneurodevelopmentoffspringperinatal periodpostnatalpregnantprenatalprogramspublic health relevanceracial minority populationrecruitrepositorysocial health determinantssuburb
项目摘要
PROJECT SUMMARY / ABSTRACT
The goal of the ECHO Ohio Cohort Site at Nationwide Children’s Hospital and The Ohio State University Wexner
Medical Center (NCH-OSUWMC) is to contribute to the ECHO Cohort by collecting and providing valuable data
on a diverse and often underserved population of participating pregnant individuals, conceiving partners, and
children who live in our region, so we can improve maternal and child health everywhere by better understanding
how exposures prior to and during pregnancy impact childhood outcomes. Nearly 1/5 of Ohio’s children live in
poverty. The rate is more than twice that for non-Hispanic Black children. Central Ohio is diverse with a rapidly
growing immigrant population including the largest ethnic Nepali and 2nd largest Somali refugee populations in
the U.S.; 1 in 6 Columbus children have an immigrant parent. The patients we serve live not only in urban,
suburban, and rural central Ohio, but also within Appalachian portions of southeast Ohio, Pennsylvania, and
West Virginia. The communities we serve are ranked poorly across multiple maternal and child health well-being
indicators, underscoring a critical need to better understand environmental influences in the perinatal period that
contribute to adverse child outcomes both locally and nationally. The NCH-OSUWMC health system is highly
experienced in contributing to large multicenter NIH studies involving pregnant individuals and children and well-
poised to contribute interdisciplinary leadership. We have maintained a large perinatal repository of clinical,
survey, and rich biospecimen data from pregnant individuals, their partners, and their children for over a decade.
Our research coordinators and investigators are highly experienced in recruiting both pregnant individuals and
children for research investigations and securely and efficiently processing health data and biospecimens. Of
note, our track record in retaining diverse subpopulations of high-risk maternal/child dyads, as well as conceiving
partners, for follow-up is strong. We provide specific expertise in evaluating lifestyle exposures in pregnancy,
most prominently in maternal cardiovascular health, and outcomes expertise in pre-, peri-, and postnatal health
and childhood neurodevelopment. We propose 1) evaluating the impact of maternal cardiovascular health during
pregnancy using the American Heart Association Life’s Essential 8 framework on child socioemotional
development and behavior to age 21, using existing ECHO Cohort Protocol core data elements and 2)
investigating, using innovative methods (continuous glucose monitoring), the association between evolving
maternal dysglycemia patterns across the peripartum period and child socioemotional development and behavior
while evaluating neonatal anthropometrics as potential mediators. We propose to evaluate the interaction
between genes and lifestyle exposures on socioemotional development via an association study complemented
with imputed -omics data. In a preconception-focused aim, we propose examining the impact of maternal and
paternal preconception cardiovascular health on socioemotional development and behavior. Our contributions
to the ECHO cohort, providing diversity and expertise, will enhance knowledge leading to improved child health.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sarah Keim其他文献
Sarah Keim的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sarah Keim', 18)}}的其他基金
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10226056 - 财政年份:2020
- 资助金额:
$ 132.58万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10650351 - 财政年份:2020
- 资助金额:
$ 132.58万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm - Administrative Supplement
学步期补充 DHA 对早产儿的长期影响和安全性 - 行政补充
- 批准号:
10727669 - 财政年份:2020
- 资助金额:
$ 132.58万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10012322 - 财政年份:2020
- 资助金额:
$ 132.58万 - 项目类别:
Long-term Effects and Safety of DHA Supplementation in Toddlerhood for Children born Preterm
学步期补充 DHA 对早产儿的长期影响和安全性
- 批准号:
10443726 - 财政年份:2020
- 资助金额:
$ 132.58万 - 项目类别:
Fatty acid supplements alter biological signatures in children with Autism Spectrum Disorder
脂肪酸补充剂改变自闭症谱系障碍儿童的生物特征
- 批准号:
10222888 - 财政年份:2017
- 资助金额:
$ 132.58万 - 项目类别:
Fatty acid supplements alter biological signatures in children with Autism Spectrum Disorder
脂肪酸补充剂改变自闭症谱系障碍儿童的生物特征
- 批准号:
10266170 - 财政年份:2017
- 资助金额:
$ 132.58万 - 项目类别:
Fatty acid supplements alter biological signatures in children with Autism Spectrum Disorder
脂肪酸补充剂改变自闭症谱系障碍儿童的生物特征
- 批准号:
10480779 - 财政年份:2017
- 资助金额:
$ 132.58万 - 项目类别:
The Development of Early Childhood Obesity in Children Born Preterm
早产儿早期肥胖的发展
- 批准号:
9112267 - 财政年份:2016
- 资助金额:
$ 132.58万 - 项目类别:
Development and Evaluation of New Breastfeeding Questions Applicable to Multiple National Surveys
适用于多项全国调查的新母乳喂养问题的开发和评估
- 批准号:
9159393 - 财政年份:2016
- 资助金额:
$ 132.58万 - 项目类别:
相似海外基金
Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
- 批准号:
MR/Z503605/1 - 财政年份:2024
- 资助金额:
$ 132.58万 - 项目类别:
Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
- 批准号:
2336167 - 财政年份:2024
- 资助金额:
$ 132.58万 - 项目类别:
Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
- 批准号:
2402691 - 财政年份:2024
- 资助金额:
$ 132.58万 - 项目类别:
Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
- 批准号:
24K12150 - 财政年份:2024
- 资助金额:
$ 132.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
- 批准号:
2341428 - 财政年份:2024
- 资助金额:
$ 132.58万 - 项目类别:
Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
- 批准号:
DE240100561 - 财政年份:2024
- 资助金额:
$ 132.58万 - 项目类别:
Discovery Early Career Researcher Award
Laboratory testing and development of a new adult ankle splint
新型成人踝关节夹板的实验室测试和开发
- 批准号:
10065645 - 财政年份:2023
- 资助金额:
$ 132.58万 - 项目类别:
Collaborative R&D
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 132.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
- 批准号:
23K07552 - 财政年份:2023
- 资助金额:
$ 132.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
- 批准号:
23K07559 - 财政年份:2023
- 资助金额:
$ 132.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)