Environmental Influences on Child Health Outcomes (ECHO) and Pregnancy in Ohio

俄亥俄州环境对儿童健康结果 (ECHO) 和怀孕的影响

• 批准号: 10746498
• 负责人: Sarah Keim
• 金额: $ 132.58万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10746498
• 关键词: 21 year old; Adult; American Heart Association; Anthropometry; Appalachian Region; Area; Behavior; Birth; Black race; Caring; Child; Child Behavior; Child Health; Childhood; Clinical; Collaborations; Communities; Complement; Conceptions; Continuous Glucose Monitor; Data; Data Collection; Data Element; Development; Dimensions; Disparate; Emotional; Enrollment; Ensure; Environmental Exposure; Ethnic Origin; Generations; Genes; Genetic; Genomic approach; Goals; Health; Health system; Immigrant; Impairment; Individual; Inequity; Infant Health; Investigation; Knowledge; Leadership; Life; Life Style; Long-Term Effects; Longitudinal Studies; Maternal Exposure; Maternal and Child Health; Measures; Mediating; Mediation; Mediator; Medical center; Methods; Molecular; Neonatal; Neurodevelopmental Impairment; Not Hispanic or Latino; Ohio; Outcome; Parents; Participant; Pathway interactions; Patients; Pattern; Pediatric Hospitals; Pennsylvania; Perinatal; Personal Satisfaction; Population; Population Heterogeneity; Postpartum Period; Poverty; Pregnancy; Pregnancy Outcome; Protocols documentation; Refugees; Research; Research Personnel; Role; Rural; Secure; Site; Surveys; Techniques; Time; Underserved Population; United States National Institutes of Health; Universities; West Virginia; Work; cardiovascular health; cohort; emerging adult; epidemiologic data; ethnic minority population; experience; follow-up; health data; high risk; improved; innovation; maternal risk; neurodevelopment; offspring; perinatal period; postnatal; pregnant; prenatal; programs; public health relevance; racial minority population; recruit; repository; social health determinants; suburb

PROJECT SUMMARY / ABSTRACT The goal of the ECHO Ohio Cohort Site at Nationwide Children’s Hospital and The Ohio State University Wexner Medical Center (NCH-OSUWMC) is to contribute to the ECHO Cohort by collecting and providing valuable data on a diverse and often underserved population of participating pregnant individuals, conceiving partners, and children who live in our region, so we can improve maternal and child health everywhere by better understanding how exposures prior to and during pregnancy impact childhood outcomes. Nearly 1/5 of Ohio’s children live in poverty. The rate is more than twice that for non-Hispanic Black children. Central Ohio is diverse with a rapidly growing immigrant population including the largest ethnic Nepali and 2nd largest Somali refugee populations in the U.S.; 1 in 6 Columbus children have an immigrant parent. The patients we serve live not only in urban, suburban, and rural central Ohio, but also within Appalachian portions of southeast Ohio, Pennsylvania, and West Virginia. The communities we serve are ranked poorly across multiple maternal and child health well-being indicators, underscoring a critical need to better understand environmental influences in the perinatal period that contribute to adverse child outcomes both locally and nationally. The NCH-OSUWMC health system is highly experienced in contributing to large multicenter NIH studies involving pregnant individuals and children and well- poised to contribute interdisciplinary leadership. We have maintained a large perinatal repository of clinical, survey, and rich biospecimen data from pregnant individuals, their partners, and their children for over a decade. Our research coordinators and investigators are highly experienced in recruiting both pregnant individuals and children for research investigations and securely and efficiently processing health data and biospecimens. Of note, our track record in retaining diverse subpopulations of high-risk maternal/child dyads, as well as conceiving partners, for follow-up is strong. We provide specific expertise in evaluating lifestyle exposures in pregnancy, most prominently in maternal cardiovascular health, and outcomes expertise in pre-, peri-, and postnatal health and childhood neurodevelopment. We propose 1) evaluating the impact of maternal cardiovascular health during pregnancy using the American Heart Association Life’s Essential 8 framework on child socioemotional development and behavior to age 21, using existing ECHO Cohort Protocol core data elements and 2) investigating, using innovative methods (continuous glucose monitoring), the association between evolving maternal dysglycemia patterns across the peripartum period and child socioemotional development and behavior while evaluating neonatal anthropometrics as potential mediators. We propose to evaluate the interaction between genes and lifestyle exposures on socioemotional development via an association study complemented with imputed -omics data. In a preconception-focused aim, we propose examining the impact of maternal and paternal preconception cardiovascular health on socioemotional development and behavior. Our contributions to the ECHO cohort, providing diversity and expertise, will enhance knowledge leading to improved child health.

项目概要/摘要 全国儿童医院和俄亥俄州立大学韦克斯纳分校 ECHO 俄亥俄队列站点的目标 医疗中心 (NCH-OSUWMC) 将通过收集和提供有价值的数据为 ECHO 队列做出贡献 针对参与的孕妇、怀孕伴侣和往往服务不足的多样化人群 生活在我们地区的儿童，因此我们可以通过更好地了解来改善各地的妇幼健康 怀孕前和怀孕期间的暴露如何影响儿童结局。俄亥俄州近 1/5 的儿童居住在 贫困。这一比率是非西班牙裔黑人儿童的两倍多。俄亥俄州中部地区多元化，发展迅速 不断增长的移民人口，其中包括最大的尼泊尔族和第二大的索马里难民人口 美国；六分之一的哥伦布儿童的父母是移民。我们服务的患者不仅生活在城市， 俄亥俄州的郊区和中部农村地区，以及俄亥俄州东南部的阿巴拉契亚地区、宾夕法尼亚州和 西弗吉尼亚州。我们服务的社区在多项妇幼健康福祉方面排名较差 指标，强调迫切需要更好地了解围产期的环境影响， 导致当地和全国的不良儿童后果。 NCH-OSUWMC 卫生系统高度 在参与涉及孕妇和儿童的大型多中心 NIH 研究以及健康状况方面具有丰富的经验 准备贡献跨学科领导力。我们拥有一个大型的围产期临床资料库， 调查以及十多年来来自孕妇及其伴侣及其子女的丰富生物样本数据。 我们的研究协调员和调查员在招募孕妇和孕妇方面拥有丰富的经验。 儿童进行研究调查并安全有效地处理健康数据和生物样本。的 请注意，我们在保留高风险孕产妇/儿童二人组的不同亚群以及受孕方面的记录 合作伙伴，跟进力度强。我们提供评估怀孕期间生活方式暴露的具体专业知识， 最突出的是孕产妇心血管健康，以及产前、围产期和产后健康的结果专业知识 和儿童时期的神经发育。我们建议 1) 评估妊娠期间孕产妇心血管健康的影响 使用美国心脏协会 Life’s Essential 8 框架对儿童社会情绪进行怀孕评估 使用现有的 ECHO 队列协议核心数据元素和 2) 到 21 岁的发育和行为 使用创新方法（连续血糖监测）调查进化之间的关联 围产期母亲血糖异常模式以及儿童社会情绪发展和行为 同时评估新生儿人体测量学作为潜在的中介因素。我们建议评估交互作用 通过关联研究补充基因和生活方式暴露对社会情感发展的影响 具有估算的组学数据。在以孕前为重点的目标中，我们建议检查孕产妇和 父亲先入为主的心血管健康对社会情绪发展和行为的影响。我们的贡献 向 ECHO 群体提供多样性和专业知识，将增强知识，从而改善儿童健康。