Core A Administrative Core

本次更新P01的中心主题是了解新生儿的肠道微生物群如何 以降低儿童后期患过敏性哮喘的风险。这将需要广泛的互动， 流行病学、环境、免疫学和生理学研究， 母亲和孩子的微生物群的变量以及这些微生物群的相互作用， 发展免疫系统。这些对早期免疫发育的影响可能有助于 儿童期过敏性哮喘的后续风险。本次更新P01的管理核心（核心A）将 再次对确保四个项目之间的生产力和协同作用负有最终责任， 四个核心。在P01联合项目主任约翰逊博士和Ownby博士的指导下，核心A是 负责优化本计划项目的科学和业务产出的行政保护伞。 与最初的P01一样，核心A的持续重点将是提供P01的监督和整合。 核心A将监督1）项目、核心、调查员、顾问之间的沟通和协作， 研究和行政人员，外部咨询委员会和NIH; 2）方法的质量， 数据和分析; 3）研究产出，主要通过介绍和出版，以促进有效和 及时传播研究结果;以及4）优化科学和业务协同作用。核心A员工 我将组织例行和特别会议，介绍和讨论项目的成果和想法 和核心，为这些会议制定科学议程，并任命和支持出版委员会， 外部咨询委员会。该核心将负责促进业务协同作用， 通过监测P01的业务和行政方面的进展和协调来提高效率。 核心A董事将定期审查研究活动，监控所有人员的生产力和效率。 项目和核心，维护文件，并协调IRB，CEAC和进度报告的提交， 参与机构。核心A将监督人事、采购和财务管理事项 包括与NIH和分包机构的赠款人员合作。 P01的创新之处在于，它汇集了多个学科和机构的专业知识， 解决一个主要的儿童健康问题，但它需要认真和周到的行政办法， 充分利用这一优势，同时尽量减少沟通障碍带来的不利影响 通过学科术语、专业知识、不同的科学观点和地理位置来介绍 距离虽然并非没有挑战，但核心A的领导者和工作人员从最初的P01中受益匪浅 经验，并将确保流程到位，以再次优化该P01团队的协同作用， 生产力

The central theme of this renewal P01 is to learn how the gut microbiota of newborn children could be altered to reduce the risk of allergic asthma in later childhood. This will require extensive interactions among epidemiological, environmental, immunologic and physiologic investigations of many potential influential variables on the microbiota of mother and child and the interactions of these microbiota to influence the developing immune system. These influences on early-life immune development likely contribute to the subsequent risk of allergic asthma during childhood. This renewal P01's Administrative Core (Core A) will again have the ultimate responsibility for assuring productivity and synergy among the four Projects and the four other Cores. Core A, under the direction of the P01 Co-Program Directors Drs. Johnson and Ownby, is the administrative umbrella responsible for optimizing scientific and operational output across this Program Project. As in the initial P01, the continuing focus of Core A will be to provide for P01 oversight and integration. Core A will oversee 1) communication and collaboration among Projects, Cores, investigators, consultants, research and administrative staff, the External Advisory Committee, and NIH; 2) the quality of methodology, data and analyses; 3) research output, primarily through presentation and publication, to promote effective and timely dissemination of findings; and 4) the optimization of scientific and operational synergy. The Core A staff will organize routine and special meetings to present and discuss results and ideas emanating from Projects and Cores, set scientific agendas for these meetings, and appoint and support a Publications Committee and External Advisory Committee. This Core will be responsible for promoting operational synergism and effectiveness through monitoring progress and coordination of operational and administrative facets of the P01. The Core A Directors will regularly review research activities, monitor the productivity and efficiency of all Projects and Cores, maintain documents, and coordinate IRB, CEAC and progress report submissions among the participating institutions. Core A will oversee matters of personnel, purchasing and fiscal management including working with NIH and grants personnel at the subcontracting institutions. This P01 is innovative in that it brings to bear expertise across multiple disciplines and institutions to address a major childhood health problem, but it requires careful and attentive administrative approaches to capitalize on this advantage while minimizing the attendant disadvantages of communication barriers introduced by disciplinary jargon, specialized expertise, different scientific perspectives, and geographic distance. While not without challenges, the Core A leaders and staff have benefited from the initial P01 experience and will assure processes are in place to once again optimize this P01 team's synergy and productivity.