System for documenting and tracking skin lesions

用于记录和跟踪皮肤病变的系统

• 批准号: 10484160
• 负责人: MEHRAN ARMAND
• 金额: $ 25.24万
• 依托单位: LUMO IMAGING LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10484160
• 关键词: Address; Affect; Agreement; Algorithms; American; Appearance; Area; Atopic Dermatitis; Awareness; Basal Cell; Body Surface; Body Weight Changes; Cancerous; Caring; Cessation of life; Clinical; Clinical Research; Computer software; Consumption; Cutaneous; Data; Death Rate; Dermatologic; Dermatologist; Dermoscopy; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Documentation; Early Diagnosis; Eczema; Evolution; Future; Goals; Health Expenditures; Health Services Accessibility; Healthcare Systems; Image; Imaging Techniques; Incidence; Inflammatory; Institutional Review Boards; Lead; Lesion; Light; Literature; Location; Longitudinal Studies; Malignant Neoplasms; Manuals; Monitor; Morphology; Participant; Pathologist; Patient Monitoring; Patients; Persons; Phase; Photography; Pigments; Procedures; Prognosis; Psoriasis; Reading; Resolution; Scanning; Screening for Skin Cancer; Screening procedure; Sensitivity and Specificity; Skin; Skin Cancer; Small Business Technology Transfer Research; Software Tools; Squamous cell carcinoma; Standardization; System; Tablets; Techniques; Technology; Telephone; Testing; Time; Treatment Cost; Treatment Efficacy; United States; Visual; Visualization; Wait Time; Work; base; cancer diagnosis; cancer type; clinical imaging; cost; high risk; improved; interest; melanoma; mortality; new growth; novel; outpatient facility; patient prognosis; point of care; primary care setting; prototype; screening; screening program; skin lesion; standard of care; teledermatology; tool; underserved community; virtual

Project Summary The objective of this STTR proposal is to develop a system for longitudinally tracking the locations and morphologic changes to all Pigmented Skin Lesions on the patient’s body. The proposed software will build on a previously developed Total Body Photography (TBP) system, called Lumo Scanner, that can provide unprecedented resolution across the entire body surface. Skin cancers, including both melanoma and non- melanoma, are the most common type of cancer in the United States. Early-stage identification of suspicious pigmented lesions (SPLs) in primary care settings can lead to improved melanoma prognosis and a possible 20- fold reduction in treatment cost. The proposed device significantly reduces the clinicians’ time required for documenting lesions and for making diagnostic decisions, thereby allowing the healthcare system to better cope with the forecasted shortages of dermatologists. The proposed technology is novel in that it: 1) provides a standardized way of referring to lesions’ locations, 2) allows dermatologists to maintain a complete historical record of every lesion 3) detect significantly changed (evolved) lesions and 4) assists dermatologists in finding cancerous lesions at their very early stages to improve overall patient prognosis. The project team has already developed a Total Body Photography (TBP) system that is unlike the commercially available systems in that it obviates the need for using a dermatoscope and can produce images of sufficient resolution that can be used for early detection of skin cancers. This device has already received an IRB and has been installed at Johns Hopkins (JHU) Outpatient Center for its first clinical study. By your reading of this proposal is under review, JHU’s 100-patient study in which the efficacy of scan-based examinations will be compared with the efficacy of traditional clinical and dermatoscopic-based skin examinations, is well on its way. Within this proposal team intends to develop a temporal study tool that can follow all PSLs over time regardless of participants’ pose and weight changes between scanning sessions. Such a system will enable clinicians to accurately monitor patients’ PSLs over time, document any changes in previously identified lesions, and detect new lesions at the point of care. Within, the two phases of this project, the team will also focus on detecting evolved lesions and optimizing the scanning software to provide a better user interface for following and diagnosing pigmented skin lesions (PSL) while reducing the amount of time it takes for the dermatologist to fully document the patients lesions of interest. Though some literature suggests the epidemy in melanoma is the result of over-screening as evidenced by the number of deaths not increasing commensurately, others suggest that the low death-rate is the result of better screening. Regardless, there is unanimous agreement that too many lesions are studied by pathologists. Lumo Scanner when combined with the facilities developed in this project, will enable technicians perform highly accurate scans and thus allow the dermatologist to spend less documenting the high-risk patients. Also, this novel device will enable teledermatology in areas where there is a scarcity of dermatologists. Additionally, the proposed device can also be used for diagnosing and accurately monitoring the efficacy of therapies for psoriasis, atopic dermatitis, and other inflammatory skin conditions. Psoriasis and atopic dermatitis are also serious global problems. In the United States, psoriasis affects about 8 million people while about 31.6 million people in the United States have some form of eczema, including atopic dermatitis.

项目摘要 这项建议的目标是开发一种纵向跟踪地点和 患者身上所有色素性皮损的形态变化。拟议的软件将建立在 以前开发的全身摄影(TBP)系统，称为Lumo扫描仪，可以提供 史无前例的整个身体表面的分辨率。皮肤癌，包括黑色素瘤和非 黑色素瘤是美国最常见的癌症类型。可疑人员的早期识别 初级保健环境中的色素性病变(SPL)可以改善黑色素瘤的预后，并可能导致20- 治疗成本降低了一倍。建议的设备显著减少了临床医生需要的时间 记录损伤并做出诊断决策，从而使医疗保健系统能够更好地应对 预计会出现皮肤科医生的短缺。提出的技术是新颖的，因为它：1)提供了 2)皮肤科医生可以通过标准化的方式查看皮损的位置，以保持完整的病史 记录每一处皮损3)发现显著变化(演变)的皮损并协助皮肤科医生发现 癌症病变在非常早期的阶段，以改善整体患者的预后。 该项目团队已经开发了一种全身摄影(TBP)系统，它不同于商业上的 可用的系统，因为它不需要使用皮肤镜，并且可以产生足够的图像 可用于皮肤癌早期检测的分辨率。此设备已收到IRB和 已经安装在约翰·霍普金斯(JHU)门诊中心进行第一次临床研究。通过您对此的阅读 JHU的100名患者的研究提案正在审查中，在该研究中，基于扫描的检查的有效性将是 与传统的临床和皮肤镜为主的皮肤检查的疗效相比，是很好的方法。 在这份提案中，团队打算开发一种时态研究工具，该工具可以随时间跟踪所有PSL 记录参与者在扫描过程中的姿势和体重变化。这样的系统将使临床医生能够 随着时间的推移，准确监控患者的PSL，记录先前识别的病变中的任何变化，并检测 在看护点有新的损伤。在这个项目的两个阶段内，团队还将专注于检测 并优化扫描软件，以提供更好的用户界面用于跟踪和 诊断色素性皮肤损害(PSL)，同时减少皮肤科医生完全 记录患者感兴趣的皮损。 尽管一些文献表明黑色素瘤的流行是过度筛查的结果， 死亡人数没有相应地增加，其他人认为低死亡率是更好的结果 放映。无论如何，一致认为太多的病变是由病理学家研究的。卢莫 当扫描仪与本项目中开发的设施相结合时，将使技术人员发挥更高的性能 准确的扫描，从而使皮肤科医生花更少的时间记录高危患者。还有，这个 新的设备将在皮肤科医生稀缺的地区实现远程皮肤病。此外， 所提出的设备还可以用于诊断和准确监测治疗方法的疗效 牛皮癣、特应性皮炎和其他炎症性皮肤状况。牛皮癣和特应性皮炎也是 严重的全球性问题。在美国，牛皮癣影响着大约800万人，而大约3160万人 美国人患有某种形式的湿疹，包括特应性皮炎。