Cardiovascular Disease Research Training Program in Haiti

摘要 心血管疾病（CVD）是最常见的非传染性疾病， 海地的发病率和死亡率。在过去的十年里，它已经超过了传染病。高血压 (HTN)是海地成年人最常见的心血管疾病危险因素，其发病时间比海地成年人早10-20年 在美国黑人中。海地HTN的潜在驱动因素包括社会决定因素，如 极端贫困、粮食不安全、高盐饮食、心理压力以及环境污染， 高铅暴露。与此同时，海地仍然是该区域艾滋病毒感染率最高的国家， 35%的艾滋病毒感染者患有HTN。为了遏制这一令人担忧的心血管疾病流行，海地迫切需要心血管疾病 为年轻调查员和研究人员提供研究培训，以提高其开展 跨学科、有影响力的CVD研究。 该提案建立在该小组在海地进行的NIH研究和Fogarty培训的约40年历史的基础上。 d 'Etude du Sarcome et des Infections Escheristes（GHESKIO）及其美国合作伙伴Weill Cornell 药Cornell-GHESKIO合作伙伴关系始于艾滋病毒，自2015年以来已扩展到 应对海地的心血管疾病疫情。我们已经建立了一个强大的基础与8个积极的国家卫生研究院和基金会赠款 在CVD研究和GHESKIO NCD临床和研究单位的创建。我们现在需要训练一个 专业CVD研究人员的熟练劳动力，他们可以扩大海地的研究组合， 将研究成果转化为实践。 这项培训计划的目标是加强研究，最终改善心血管疾病相关的 海地和全世界的健康状况。我们的三个培训目标包括：1）提供长期的指导 在Quisqueya大学通过公共卫生硕士课程对8名海地临床医生科学家进行CVD研究培训， 指导海地的CVD研究; 2）培训24名CVD知识和技术方面的中期研究人员 通过由海地和国际教师教授的新的1年CVD核心研究课程的研究技能; 和3）建立一个由6个CVD诊所组成的CVD实施网络，以增加对CVD的吸收、优化和 评估海地高影响力的心血管疾病干预措施。网络诊所的工作人员将有机会 短期培训，包括参加每月的心血管病大圆桌会议和参加为期1周的 CVD核心研究课程中的研讨会。此外，我们还将赞助一年一度的国家CVD 研究会议，重点是学员的领导力和职业发展。拟议方案是 海地的第一个CVD研究培训计划，并带来了CVD课程的创新，新的研究 导师和教师，以及一个平台，为整个CVD干预措施的实施能力建设 国家我们致力于在海地培训下一代CVD研究人员。

ABSTRACT Cardiovascular disease (CVD) is the most common non-communicable disease and the leading cause of morbidity and mortality in Haiti. It has surpassed infectious diseases over the past decade. Hypertension (HTN) is the single most common CVD risk factor in Haitian adults and its onset is 10-20 years earlier than among Black Americans in the US. Potential drivers of HTN in Haiti include social determinants such as extreme poverty, food insecurity, a high salt diet, psychological stress, and also environmental pollutants such as high lead exposure. Concurrently, Haiti continues to have the highest HIV prevalence in the region with over 35% of persons living with HIV having HTN. To curb this alarming CVD epidemic, Haiti urgently needs CVD research training for both young investigators and research staff in order to increase its capacity to conduct interdisciplinary, impactful CVD research. This proposal builds on a ~40-year history in Haiti of NIH research and Fogarty training by the Groupe d’Etude du Sarcome et des Infections Opportunistes (GHESKIO) and its US collaborating partner, Weill Cornell Medicine. The Cornell-GHESKIO partnership began with a focus on HIV and since 2015 has expanded to address the CVD epidemic in Haiti. We have built a strong foundation with 8 active NIH and foundation grants in CVD research and the creation of the GHESKIO NCD Clinical and Research Unit. We now need to train a skilled workforce of specialized CVD researchers who can expand Haiti’s research portfolio and transform research findings into practice. The goal of this training program is to strengthen research that will ultimately improve CVD-related health outcomes in Haiti and the world. Our three training objectives include: 1) to provide long-term mentored CVD research training to 8 Haitian clinician scientists through MPH coursework at Quisqueya University with mentored CVD research in Haiti; 2) to train 24 medium-term research staff in CVD knowledge and technical research skills through a new 1-year CVD Core Research Course taught by Haitian and international faculty; and 3) to establish a CVD Implementation Network of 6 CVD clinics to increase the uptake, optimization, and evaluation of high-impact CVD interventions in Haiti. Staff at the Network clinics will have opportunities for short-term training including participation in monthly CVD Grand Rounds and participation in 1-week workshops within the CVD Core Research Course. In addition, we will sponsor an annual national CVD Research Conference with a focus on trainee leadership and career development. The proposed program is the first CVD research training program in Haiti and brings innovation in CVD coursework, new research mentors and faculty, and a platform for building implementation capacity for CVD interventions across the country. We are committed to training the next generation of CVD researchers in Haiti.