Global Health Research and Training in Cardiovascular Disease

心血管疾病的全球健康研究和培训

• 批准号: 10427988
• 负责人: Margaret Leighton McNairy
• 金额: $ 12.42万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10427988
• 关键词: 2019-nCoV; Adult; Amlodipine; Antihypertensive Agents; Area; Blood; Blood Pressure; Blood Screening; COVID-19; COVID-19 complications; Cardiac; Cardiac Death; Cardiovascular Diseases; Caring; Case-Control Studies; Cessation of life; Clinic; Clinical; Clinical Investigator; Clinical Trials; Cohort Studies; Communicable Diseases; Communities; Consumption; Data; Development; Diabetes Mellitus; Diastolic blood pressure; Disease; Early treatment; Echocardiography; Environment; Event; Faculty; Family; Fellowship; Foundations; Functional disorder; Funding; Future; General Population; Goals; Gold; HIV; HIV/TB; Haiti; Haitian; Health; Heart failure; Hypertension; Incidence; Inflammation; International; Intervention; Kidney Diseases; Laboratories; Lead; Lead levels; Leadership; Learning; Longitudinal cohort; Mass Spectrum Analysis; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Myocardial Infarction; Myocardial dysfunction; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Disease; Natural History; Obesity; Occupational; Outcome; PF4 Gene; Participant; Persons; Population; Postdoctoral Fellow; Poverty; Prevalence; Prevention; Randomized; Randomized Clinical Trials; Reach Effectiveness Adoption Implementation and Maintenance; Recording of previous events; Research; Research Project Grants; Research Training; Risk Factors; Role; Safety; Serology; Severities; Site; Smoking; Sodium; Sodium Chloride; Source; Spottings; Stroke; Tanzania; Testing; Time; Training; Training Programs; Unhealthy Diet; United States; Urine; Woman; base; biobank; blood lead; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical epidemiology; clinical trial implementation; cohort; design; early phase clinical trial; environmental Pb exposure; experience; global health; hypertension control; hypertension treatment; hypertensive; immune activation; implementation evaluation; implementation science; improved; kidney dysfunction; low income country; medication compliance; mortality; patient oriented; patient oriented research; physical inactivity; prehypertension; premature; primary outcome; programs; randomized trial; screening; social determinants; standard care; stool sample; training opportunity; training project

ABSTRACT: The goals of this K24 proposal are to train clinical investigators in the conduct of patient-oriented cardiovascular disease (CVD) research primarily in Haiti, with a new project in Tanzania and to conduct a new study on environmental lead exposure and CVD risk factors in Haiti (Aim 1). The training also leverages four currently funded CVD research projects in Haiti (Aims 2-5), and a funded CVD research project in Tanzania (Aim 6). United States trainees will spend ~50-60% of their time at international research sites in Haiti and Tanzania, which have onsite Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. The common theme of the projects is patient-oriented CVD research in the areas of clinical epidemiology, clinical trials, CVD-infectious diseases, and implementation science. The projects include: 1. Environmental lead exposure and CVD risk factors in Haiti 2. Clinical epidemiology of CVD risk factors, diseases, and poverty-related social determinants in Haiti 3. Randomized clinical trial of early hypertension treatment among persons living with HIV 4. COVID-19 and cardiac dysfunction 5. Implementation of hypertensive screening and management 6. Heart failure in Tanzania The focus of research training will be on postdoctoral clinical investigators who have completed their advanced degree training. Dr. McNairy has an impeccable history of excellence in research mentorship and serves in leadership roles in the Weill Cornell Global Health Research Fellowship and the Weill Cornell Women in Global Health Research Initiative. Trainees will be mentored by Dr. McNairy and will participate in research projects in Haiti (Aims 1-5) and Tanzania (Aim 6). These six projects have both clinical and laboratory aspects and offer trainees a broad research experience. Trainees learn through the conduct of their mentored research project and the opportunity to interact with colleagues working on studies other than their own. The K24 award will allow Dr. McNairy to decrease her administrative and clinical responsibilities and commit 50% effort to CVD- related research and mentorship of US trainees. Her long-term goal is to build a world-class CVD global health research and training program to improve CVD-related health outcomes among the world's poorest populations.

摘要：本K24提案的目标是培训临床研究者进行以患者为导向的 心血管疾病（CVD）研究主要在海地，在坦桑尼亚有一个新的项目，并进行一个新的 海地环境铅暴露和心血管疾病危险因素研究（目标1）。培训还利用了四个 目前在海地资助的CVD研究项目（目标2-5）和在坦桑尼亚资助的CVD研究项目 (Aim 6）。美国受训人员将在海地的国际研究地点花费约50-60%的时间， 坦桑尼亚，拥有现场威尔康奈尔大学教师，长期的国际合作者，以及杰出的 研究训练的环境。这些项目的共同主题是以患者为导向的心血管疾病研究， 临床流行病学、临床试验、心血管疾病-传染病和实施科学领域。的 项目包括： 1.海地的环境铅暴露和心血管疾病危险因素 2.海地CVD危险因素、疾病和贫困相关社会决定因素的临床流行病学 3. HIV感染者高血压早期治疗的随机临床试验 4. COVID-19和心功能障碍 5.实施高血压筛查和管理 6.坦桑尼亚心力衰竭 研究培训的重点将是博士后临床研究者谁已经完成了他们的高级 学位培训。McNairy博士在研究指导方面有着无可挑剔的卓越历史， 在威尔康奈尔全球健康研究奖学金和威尔康奈尔全球女性中担任领导角色 健康研究倡议。受训人员将由McNairy博士指导，并将参加 海地（目标1-5）和坦桑尼亚（目标6）。这六个项目具有临床和实验室两个方面， 学员具有广泛的研究经验。学员通过指导研究项目的进行学习 以及与从事其他研究的同事互动的机会。K24奖项将 允许McNairy博士减少她的行政和临床责任，并将50%的精力投入到CVD中- 美国学员的相关研究和指导。她的长期目标是打造世界一流的CVD全球健康 研究和培训计划，以改善世界上最贫困人口的心血管疾病相关健康结果 人口。