Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you - BETTER4U

通过为您量身定制的生物学和行为干预措施来预防肥胖 - BETTER4U

• 批准号: 10106435
• 金额: $ 30.92万
• 依托单位: BRADFORD TEACHING HOSP NHS FOUND TRUST
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10106435
• 关键词: Preventing; obesity; through; Biologically; bEhaviorally

BETTER4U aims at the identification and personalized management of all weight gain determinants to battle the increasingly rising numbers of overweight/obesity, via homogenous, globally adaptable and practically assessed public health initiatives and key interventions. Building on previous key projects and biobanks, the project will focus on the hitherto neglected impact of the polygenic background of weight gain on the effectiveness of lifestyle interventions for weight management in people with overweight/obesity. BETTER4U aims to probe into the global obesity challenge, study the problem and offer solutions in a tangible realistic way with the assistance of modern AI technologies and the contribution of experts around the world. BETTER4U will be realized through the following objectives: 1. To comprehensively understand and decipher genetics, metabolomics, microbiota,socio-economic, geographical, cultural and lifestyle features linked to weight gain throughout the life course, via meta-analyses (BETTER4U data from >50 studies, >1 million individuals) and extensive literature meta-review. 2.To develop the BETTER4U intervention methodology for weight gain prevention, based on a causal AI model of obesity determinants and a pilot study in 7 European countries. 3.To deploy technology assisted, real-time monitoring toolsto measure detailed behavioral indicators and their relation to the environmental context. 4.To evaluate the efficacy of the novel BETTER4U intervention methodology in a controlled, randomized clinical trial, based on individually-tailored recommendations for lifestyle change. 5.To maximize transferability and applicability of the BETTER4U intervention methodology by identifying implementation barriers and facilitators, as well as to evaluate implementation outcomes in both participants and stakeholders. 6. To develop and disseminate the BETTER4Uobesity prevention intervention methodology guidelines using a people centred, sustainable care approach

BETTER4U旨在通过同质化、全球适应性和实际评估的公共卫生倡议和关键干预措施，识别和个性化管理所有体重增加的决定因素，以抗击日益增长的超重/肥胖人数。在以前的关键项目和生物库的基础上，该项目将侧重于迄今被忽视的体重增加的多基因背景对超重/肥胖者体重管理生活方式干预的有效性的影响。BETTER4U的目标是在现代人工智能技术的帮助下，借助世界各地的专家的贡献，探索全球肥胖挑战，研究问题，并以切实现实的方式提供解决方案。BETTER4U将通过以下目标实现：1.通过元分析(来自&gt；50项研究的BETTER4U数据，&gt；100万人)和广泛的文献元回顾，全面了解和破译与整个生命过程中体重增加有关的遗传学、代谢组学、微生物区系、社会经济、地理、文化和生活方式特征。2.基于肥胖决定因素的因果人工智能模型和在7个欧洲国家进行的一项试点研究，开发BETTER4U干预方法以预防体重增加。3.部署技术辅助的实时监测工具，以衡量详细的行为指标及其与环境背景的关系。4.在一项对照的随机临床试验中，根据针对改变生活方式的个人定制建议，评估新型BETTER4U干预方法的有效性。5.通过确定执行障碍和促进者，最大限度地提高BETTER4U干预方法的可转移性和适用性，并评估参与者和利益攸关方的执行结果。6.采用以人为本的可持续护理方法，制定和传播BETTER4U肥胖预防干预方法指南