CORE A: Administrative Core

摘要/摘要 管理核心 行政核心(AC)是神经变性和翻译中心成功的先行者 神经科学(CNTN)。CNTN是一个多学科的、主题连贯的、以使命为导向的、翻译的 神经科学研究计划专注于内华达州南部的神经退行性疾病(NDD)。这个 该中心是位于拉斯维加斯的克利夫兰临床卢鲁沃脑健康中心(LRCBH)之间的动态合作 内华达州维加斯(内华达州)和内华达大学拉斯维加斯(UNLV)。我们的研究中心对于 南卡罗来纳州的人口演变。国家官员强烈支持我们的 计划并定期与AC领导层互动，询问进度和支持需求。 在CNTN第一阶段，AC完成的工作改变了翻译神经科学 内华达州南部的研究环境。AC的显著成就是：1-对尖端技术的投资 神经科学和NDD研究的基础设施；2--指导6名初级调查人员(JIS) 毕业于独立职位；3-创建临床和翻译研究核心(CTRC)，以 建立一个新的新城疫患者纵向队列并深入表型；以及4--建立一个 数据管理和统计核心，用于安全存储和管理大型生物医学数据集，并协助CNTN 调查人员进行了统计分析。AC利用了从创新方法汇编的数据，这些方法由 评估股负责监测国家过渡网络核心和项目的运作。 在第二阶段，咨询委员会打算利用评估股的数据进行决策。数据将 就如何优化支持新技术的研究基础设施的发展制定战略 项目、CNTN调查员的职业发展，以及Cobre支持期之后的可持续性。 我们战略的第一步是通过两名联席董事(Sabbagh博士和 Kinney)和一名助理主任(Cummings博士)，以有效管理CNTN的快速增长 进取号。我们新的AC领导层雄心勃勃，希望在第二阶段实现五个具体目标。第一，AC将 加强CNTN核心、项目和咨询委员会之间的协调。第二，空调局将推进 通过增加我们的队列规模和加强基础研究项目进行科学研究，包括 这些项目由初级和试点项目调查人员进行。第三，咨询委员会将促进所有人的职业发展 CNTN人员。第四，咨询委员会将促进对CNTN活动的健全评估过程，以进一步利用 用于决策的数据。第五，AC将利用Cobre、机构、行业和慈善机构的支持来 强调南卡罗来纳州神经科学研究的可持续未来。因此，AC领导者完全是 致力于在南卡罗来纳州发展翻译神经科学研究生态系统，并协助州政府 官员们正在寻找有效的应对措施，以遏制即将在内华达州爆发的新城疫疫情。

SUMMARY/ABSTRACT Administrative Core The Administrative Core (AC) is spearheading the success of the Center for Neurodegeneration and Translational Neuroscience (CNTN). The CNTN is a multidisciplinary, thematically cohesive, mission-oriented, translational neuroscience research program focused on neurodegenerative diseases (NDD) in Southern Nevada (NV). The Center is a dynamic collaboration between the Cleveland Clinic Lou Ruvo Center for Brain Health (LRCBH) in Las Vegas, Nevada (NV), and the University of Nevada Las Vegas (UNLV). Our research center is very significant for the demographic evolution of Southern NV. This is evidenced by the fact that State Officials strongly support our project and interact regularly with AC leadership to inquire about progress and need for support. During CNTN Phase 1, the work accomplished by AC has transformed the translational neuroscience research environment in Southern NV. The significant achievements of AC are: 1- the investment in cutting-edge infrastructure for neuroscience and NDD research; 2- the mentoring of six Junior Investigators (JIs) who graduated with independent positions; 3- the creation of a Clinical and Translational Research Core (CTRC) to build and deeply phenotype a new longitudinal cohort of patients suffering NDD; and 4- the establishment of a Data Management and Statistics Core to securely store and manage large biomedical datasets and assist CNTN investigators with statistical analyses. AC has utilized the data compiled from innovative methods developed by the Assessment Unit to monitor the operations of CNTN Cores and projects. For Phase 2, the AC intends to exploit the data from the Assessment Unit for decision-making. The data will be scrutinized to strategize on how to optimize the development of research infrastructure that will support new projects, the career development of CNTN investigators, and sustainability beyond the COBRE support period. The first step in our strategy is the augmentation of the AC leadership with two co-Directors (Drs. Sabbagh and Kinney) and one Assistant Director (Dr. Cummings) to efficiently manage the rapid growth of the CNTN enterprise. Our new AC leadership ambitions to accomplish five specific aims during Phase 2. First, AC will enhance the coordination of CNTN Cores, projects, and advisory Committees. Second, the AC will advance scientific research by increasing the size of our cohort and fortifying fundamental research projects, including the projects by junior and pilot project investigators. Third, the AC will enhance the career development of all CNTN personnel. Fourth, the AC will foster a robust assessment process of CNTN activities to further use the data for decision-making. Fifth, AC will utilize COBRE, institutional, industry, and philanthropic support to accentuate the sustainable future of neuroscience research in Southern NV. Therefore, AC leaders are fully committed to develop the translational neuroscience research ecosystem in Southern NV and assist State Officials with finding an impactful response to curb the upcoming NDD pandemic in NV.