Genetic control of tissue growth in animals

动物组织生长的遗传控制

• 批准号: FT200100242
• 负责人: Dr Barry Thompson
• 金额: $ 72.19万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT200100242
• 关键词: Genetic; control; tissue; growth; animals

This project aims to understand how the animal body grows. This project expects to generate new knowledge and understanding of the genetic programs that govern the size and shape of animal tissues, through use of cutting-edge genome editing approaches in laboratory animals. Expected outcomes of this project include the production of genetically engineered animals with altered tissue growth, development of new theories for how tissue growth is normally controlled and how it can be manipulated industrially. This should provide significant benefits, impacting stem cell biology (improving stem cell production), tissue engineering (improving growth of artificial tissues), veterinary science and agriculture (improving productivity).

这个项目旨在了解动物身体是如何生长的。该项目希望通过在实验动物中使用尖端的基因组编辑方法，对控制动物组织大小和形状的遗传程序产生新的知识和理解。这个项目的预期成果包括生产改变组织生长的基因工程动物，发展关于组织生长如何正常控制以及如何在工业上操纵的新理论。这将带来显著的好处，影响干细胞生物学（改善干细胞生产）、组织工程（改善人工组织的生长）、兽医科学和农业（提高生产力）。