Methods Core

方法核心将确保宾夕法尼亚大学自杀创新的方法创新和严谨性。 预防实施研究中心的研究。该核心将满足以下方面的需要， 利用INSPIRE研究提供的机会，开发、实施和测试新方法， 解决自杀预防和实施科学交叉点的三个主要问题：1）什么是 在各种环境中调整和实施循证自杀预防干预措施的最佳方法 优化覆盖面、有效性和可持续性？2)我们如何准确有效地衡量对 基于证据的自杀预防干预措施的规模扩大？3)当我们从研究转向实践时， 我们是否提供了可用于系统规划的相关成本的准确信息？的方法 核心将领导这些新工具以及中心研究成果的传播工作，确保 INSPIRE成为当地和国家的研究，实践和消费者社区以外的资源 宾夕法尼亚大学方法核心成员将是自杀预防，实施 科学、统计学、经济学、机器学习、定性研究和参与式设计。方法和 这些学科的模型将加强我们的项目。方法核心有四个具体目标。 目标1：作为一个科学孵化器，完善和开发新方法，以应对该领域的三大挑战 自杀预防研究，包括（a）优化干预适应和实施策略 设计;（B）使用机器学习开发用于保真度测量的高效且有效的策略;以及（c） 推进衡量自杀预防干预措施实施成本的科学。目标2：提供 集中的科学评估、数据管理、统计和人类受试者保护 支持INSPIRE项目、试点研究和后续研究应用。核心将确保严格 并通过集中机构，在所有中心研究中遵守最高的道德和研究标准 审查委员会和数据安全性监查委员会审查研究设计和数据分析资源。的 核心方案将通过使用共同措施和数据，最大限度地发挥数据汇集和共享的潜力 协调。目标3：传播INSPIRE科学资源。我们的研究结果将为两项研究提供信息， 目标1将导致研究工具，将免费提供给自杀 和其他研究人员。我们将利用国家网络，宾夕法尼亚大学的通信， 该网络还将利用国际空间信息系统和国际空间信息系统网站，向多个部门广泛传播这些资源。目标4：确保 严格评估INSPIRE的研究生产力和影响力，提供战略，方法， 为行政核心提供技术支持。我们将应用定量评估指标和定性研究 优化对INSPIRE的评估。

The Methods Core will ensure the methodological innovation and rigor of the Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center’s studies. The Core will respond to the needs of and leverage the opportunities provided by INSPIRE research to develop, implement, and test new methods to address three major questions at the intersection of suicide prevention and implementation science: 1) What are the best ways to adapt and implement evidence-based suicide prevention interventions in a variety of settings to optimize reach, effectiveness, and sustainability? 2) How do we accurately and efficiently measure fidelity to evidence-based suicide prevention interventions upon scale-up? 3) As we move from research to practice, how do we provide accurate information on associated costs that can be used for system planning? The Methods Core will lead dissemination efforts for these new tools as well as Center research findings, ensuring that INSPIRE becomes a local and national resource to the research, practice, and consumer communities beyond the University of Pennsylvania. Method Core members will be experts in suicide prevention, implementation science, statistics, economics, machine learning, qualitative research, and participatory design. Methods and models from each of these disciplines will undergird our projects. The Methods Core has four Specific Aims. Aim 1: As a scientific incubator, refine and develop new methods to answer three major challenges in the field of suicide prevention research, including (a) optimizing intervention adaptation and implementation strategy design; (b) developing efficient and effective strategies for fidelity measurement using machine learning; and (c) advancing the science of measuring implementation costs for suicide prevention interventions. Aim 2: Provide centralized state-of-the-science assessment, data management, statistical, and human subject protections support to INSPIRE Projects, Pilot Studies, and subsequent research applications. The Core will ensure rigor and adherence to highest ethical and research standards across all Center research by centralizing Institutional Review Board and Data Safety Monitoring Board review and study design and data analysis resources. The Core will maximize the potential for data pooling and sharing through use of common measures and data harmonization. Aim 3: Disseminate INSPIRE scientific resources. Our research findings will inform both research and practice in suicide prevention; Aim 1 will result in research tools that will be made freely-available to suicide and other researchers. We will leverage national networks, University of Pennsylvania’s communications apparatus, and the INSPIRE website to disseminate these resources widely to multiple sectors. Aim 4: Ensure rigorous evaluation of INSPIRE’s research productivity and impact by providing strategic, methodological, and technical support to the Administrative Core. We will apply quantitative evaluation metrics and qualitative study to optimize evaluation of INSPIRE.