Methods Core

方法核心将确保宾夕法尼亚大学自杀创新的方法论创新和严谨 预防实施研究(INSPIRE)中心的研究。核心将响应和的需求 利用激励研究提供的机会来开发、实施和测试新方法 解决自杀预防和实施科学交叉的三个主要问题：1)什么是 在各种环境中采用和实施循证自杀预防干预的最佳方式 要优化覆盖范围、有效性和可持续性？2)我们如何准确、高效地衡量忠诚度 循证自杀预防干预扩大规模？3)随着我们从研究转向实践，如何 我们是否提供了可用于系统规划的相关成本的准确信息？这些方法 CORE将领导这些新工具的传播工作以及中心的研究成果，确保 Inspire成为研究、实践和消费者社区以外的地方和国家资源 宾夕法尼亚大学。方法核心成员将是自杀预防、实施方面的专家 科学、统计学、经济学、机器学习、定性研究和参与式设计。方法和 这些学科中的每一个模型都将巩固我们的项目。核心方法有四个具体目标。 目标1：作为科学孵化器，提炼和开发新方法，以应对该领域的三大挑战 自杀预防研究，包括(A)优化干预适应和实施战略 (B)利用机器学习制定高效率和有效的保真度测量策略；和(C) 推进衡量自杀预防干预措施实施成本的科学。目标2：提供 集中化的科学状况评估、数据管理、统计和人类主体保护 支持激发项目、先导研究和后续研究应用。核心将确保严谨 并通过集中机构研究来遵守所有中心研究的最高道德和研究标准 审查委员会和数据安全监测委员会审查和研究设计和数据分析资源。这个 CORE将通过使用共同的措施和数据最大限度地发挥数据汇集和共享的潜力 协调一致。目标3：传播灵感科学资源。我们的研究结果将为这两项研究提供信息 和自杀预防的实践；目标1将导致研究工具免费提供给自杀 和其他研究人员。我们将利用国家网络，宾夕法尼亚大学的通信 该机构还与INSPIRE网站合作，向多个部门广泛传播这些资源。目标4：确保 严格评估INSPIRE的研究效率和影响，通过提供战略、方法和 为管理核心提供技术支持。我们将采用定量评估指标和定性研究 优化对激励的评价。

The Methods Core will ensure the methodological innovation and rigor of the Penn Innovation in Suicide Prevention Implementation Research (INSPIRE) Center’s studies. The Core will respond to the needs of and leverage the opportunities provided by INSPIRE research to develop, implement, and test new methods to address three major questions at the intersection of suicide prevention and implementation science: 1) What are the best ways to adapt and implement evidence-based suicide prevention interventions in a variety of settings to optimize reach, effectiveness, and sustainability? 2) How do we accurately and efficiently measure fidelity to evidence-based suicide prevention interventions upon scale-up? 3) As we move from research to practice, how do we provide accurate information on associated costs that can be used for system planning? The Methods Core will lead dissemination efforts for these new tools as well as Center research findings, ensuring that INSPIRE becomes a local and national resource to the research, practice, and consumer communities beyond the University of Pennsylvania. Method Core members will be experts in suicide prevention, implementation science, statistics, economics, machine learning, qualitative research, and participatory design. Methods and models from each of these disciplines will undergird our projects. The Methods Core has four Specific Aims. Aim 1: As a scientific incubator, refine and develop new methods to answer three major challenges in the field of suicide prevention research, including (a) optimizing intervention adaptation and implementation strategy design; (b) developing efficient and effective strategies for fidelity measurement using machine learning; and (c) advancing the science of measuring implementation costs for suicide prevention interventions. Aim 2: Provide centralized state-of-the-science assessment, data management, statistical, and human subject protections support to INSPIRE Projects, Pilot Studies, and subsequent research applications. The Core will ensure rigor and adherence to highest ethical and research standards across all Center research by centralizing Institutional Review Board and Data Safety Monitoring Board review and study design and data analysis resources. The Core will maximize the potential for data pooling and sharing through use of common measures and data harmonization. Aim 3: Disseminate INSPIRE scientific resources. Our research findings will inform both research and practice in suicide prevention; Aim 1 will result in research tools that will be made freely-available to suicide and other researchers. We will leverage national networks, University of Pennsylvania’s communications apparatus, and the INSPIRE website to disseminate these resources widely to multiple sectors. Aim 4: Ensure rigorous evaluation of INSPIRE’s research productivity and impact by providing strategic, methodological, and technical support to the Administrative Core. We will apply quantitative evaluation metrics and qualitative study to optimize evaluation of INSPIRE.