Research Core

研究核心

• 批准号: 10488258
• 负责人: Kristina Simonyan
• 金额: $ 43.64万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-15 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488258
• 关键词: Adherence; Behavioral; Biological Markers; Biometry; Blood specimen; Brain imaging; California; Characteristics; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collection; Data; Data Analyses; Data Analytics; Data Collection; Data Science; Data Science Core; Development; Diagnostic; Differential Diagnosis; Disease; Ear; Electromyography; Ensure; Evaluation; Eye; Functional disorder; Future; General Hospitals; Genotype; Image; Larynx; Link; Massachusetts; Modeling; Monitor; Neurologic; Outcome Study; Participant; Patients; Peripheral; Phenotype; Protocols documentation; Psychophysics; Questionnaires; Research; Research Activity; Research Personnel; Resource Sharing; Risk Factors; San Francisco; Severities; Site; Spastic Dysphonias; Speech; Speech Acoustics; Standardization; Symptoms; Testing; Treatment outcome; Tremor; Universities; Utah; Voice; analytical tool; base; clinical database; clinical phenotype; cohort; computerized data processing; data acquisition; data anonymization; data harmonization; data repository; data sharing; data standards; data submission; data tools; diagnostic biomarker; investigator training; kinematics; machine learning algorithm; multimodality; neuroimaging; neuropsychiatry; next generation; prediction algorithm; recruit; repository; respiratory; screening; tool

PROJECT SUMMARY / ABSTRACT The Next-Generation Clinical Research and Data Science Core will be jointly led by Drs. Simonyan, Nagarajan and Barkmeier-Kraemer. The Core will monitor clinical and research activities of all Center sites, including Massachusetts Eye and Ear Infirmary (MEEI), Massachusetts General Hospital (MGH), University of Utah (UofU), and University of California San Francisco (UCSF). The Core will be responsible for the development of comprehensive clinical and imaging data repositories of patients with laryngeal dystonia and voice tremor and the use of these data for the development and testing of machine-learning algorithms for differential diagnosis of these disorders and the assessment of treatment outcomes. The Next-Generation Clinical Research and Data Science Core will pursue the following two specific aims: (1) Comprehensive clinical phenotyping; (2) Research data repository, and (3) Predictive data analytics. The Core's significance is in developing and implementation of standardized data collection and analytical tools for their availability to all Projects and associated investigators. In addition, data analytics based on common data across different Projects and Center sites will facilitate the development of unified diagnostic and treatment biomarkers for each of these disorders.

项目概要/摘要 下一代临床研究和数据科学核心将由博士共同领导。西蒙尼安, 纳加拉詹和巴克梅尔-克雷默。核心将监控所有中心站点的临床和研究活动， 包括马萨诸塞州眼耳医院 (MEEI)、马萨诸塞州总医院 (MGH)、麻省大学 犹他州 (UofU) 和加州大学旧金山分校 (UCSF)。核心将负责 开发喉肌张力障碍患者的综合临床和影像数据存储库 声音颤抖以及使用这些数据来开发和测试机器学习算法 这些疾病的鉴别诊断和治疗结果的评估。下一代 临床研究和数据科学核心将追求以下两个具体目标：（1）综合性 临床表型分析； (2) 研究数据存储库，以及 (3) 预测数据分析。 Core的意义在于 开发和实施标准化数据收集和分析工具，以供所有人使用 项目和相关研究人员。此外，基于跨不同领域的通用数据的数据分析 项目和中心站点将促进统一诊断和治疗生物标志物的开发 这些疾病中的每一种。