Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremor
Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremor
批准号:
10488253
负责人:
Kristina Simonyan
金额:
$74.3万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
未结题
起止时间:
2021-09-15 至 2026-08-31
关键词:
AcousticsAddressAffectAnestheticsBehavioralBehavioral trialBrainBrain imagingBupivacaineCharacteristicsClinicalClinical ManagementCommunicationCongenital neurologic anomaliesCryingDeformityDifferential DiagnosisDiseaseDysphoniaDystoniaEEG-based imagingEtiologyEventFeedbackFinancial compensationFocal DystoniasFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHumanImpairmentKnowledgeLaryngeal MucosaLarynxLearningMagnetic Resonance ImagingMagnetoencephalographyMissionModelingMotorMovementNatureNeuraxisNeurologic Voice DisorderNeuronal PlasticityPatientsPeripheralPersonsPhonationProcessProductionPublic HealthResearchRiskRoleSpastic DysphoniasSpeechTherapeuticTremorUnited States National Institutes of HealthVoiceauditory feedbackbasebehavioral responseclinical phenotypedisabilityexperimental studyfunctional disabilityfunctional magnetic resonance imaging/electroencephalographymotor learningmultimodalitynervous system disorderneural correlateneuroimagingnext generationnoninvasive brain stimulationnovel strategiesreduce symptomsrelating to nervous systemresponsescreeningsensory feedbacksequence learningsomatosensorytemporal measurement
中文摘要
项目概要/摘要
喉发声困难(LD)和声音震颤(VT)是损害言语的神经性语音障碍
生产LD的特征(即,在说话时发生,但不是笑或哭),
没有物理性喉部异常提示LD可能是一种影响任务特异性控制的疾病
中枢神经系统(CNS)的发音。类似地,VT经常在没有任何明确的外周血管的情况下观察到。
喉病因学,也提示中枢起源,但与LD的受累不同。的总目标
该项目旨在描述中枢神经系统病理生理学的共同和独特特征,
神经性语音障碍,LD和VT。言语行为是一个动态的过程,包括初始声门
运动、发声和对感觉反馈波动的代偿反应
发声识别LD和VT中的特定功能障碍需要清楚地了解何时
发声的过程,以及中枢神经系统中异常活动发生的位置。由于他们的时间差,
解决,以前的神经影像学研究还没有能够解决的问题,当异常的中枢神经系统
激活相对于特定发声事件发生。因此,关于潜在病因的关键线索
在这些疾病中很可能被忽略了。在这里,我们提出了一个多模式脑成像评估中枢神经系统
与LD和VT相关的异常。具体的目的是检查:1)空间和时间CNS
2)感觉运动对中枢神经系统病理生理的调节;
(3)运动学习与中枢神经系统病理生理学。LD和VT的未来治疗方法可以通过以下方式开发:
针对本项目中确定的CNS病理生理机制。例如,该项目将有助于
基于疾病特异性病理生理学,鉴定具有治疗潜力的神经靶点,
侵入性和非侵入性脑刺激。
英文摘要
PROJECT SUMMARY / ABSTRACT
Laryngeal dysphonia (LD) and Voice Tremor (VT) are neurological voice disorders that impair speech
production. The characteristic feature of LD (i.e., occurring during speaking but not laughing or crying) and the
lack of physical laryngeal abnormalities suggests that LD is likely a disorder affecting the task-specific control
of phonation by the central nervous system (CNS). Similarly, VT is often observed without any clear peripheral
laryngeal etiology, also suggesting a central origin but distinct from that affected in LD. The overall goal of
this project is to characterize the common and distinct features of CNS pathophysiology in the
neurological voice disorders, LD and VT. The act of speech is a dynamic process, including initial glottal
movement, voice onset, and compensatory responses to sensory feedback fluctuations during sustained
phonation. Identifying specific functional impairments in LD and VT requires a clear understanding of when in
the process of phonation, as well as where in the CNS, aberrant activity occurs. Due to their poor temporal
resolution, prior neuroimaging studies have not been able to address the question of when abnormal CNS
activation occurs relative to specific phonation events. As a result, critical clues about the underlying etiologies
in these disorders have likely been missed. Here, we propose a multimodal brain imaging assessment of CNS
abnormalities associated with LD and VT. The specific aims are to examine: 1) Spatial and temporal CNS
pathophysiology during speech and other vocal tasks; 2) Sensorimotor modulations on CNS pathophysiology;
and 3) Motor learning and CNS pathophysiology. Future treatments for LD and VT can be developed by
targeting CNS pathophysiological mechanisms identified in this project. For example, this project will help
identify neural targets that have a therapeutic potential based on disorder-specific pathophysiology for both
invasive and non-invasive brain stimulation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremor
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批准号:10340121
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依托单位:
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资助金额:$36.13万
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负责人:Kristina Simonyan
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依托单位:
Next-generation clinical phenotyping and pathophysiology of laryngeal dystonia and voice tremor
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海外基金