Ambient Air Pollution, Weather, and Placental Abruption (APWA)

环境空气污染、天气和胎盘早剥 (APWA)

基本信息

项目摘要

ABSTRACT Placental abruption results in hemorrhage, ischemia, and fetal hypoxia, placing a tremendous health burden on both the mother and the newborn. Efforts to understand the etiology of this devastating obstetrical complication have been disap- pointing. This project will delineate environmentally-associated pathways to abruption and determine the impact of pol- lutant triggers that are implicated in acute versus chronic placental abruption. Given that one-fourth of all abruption cases have an acute etiology and 15% of abruptions may recur in future pregnancies, the role of environmental triggers is a critically important, yet unexplored, opportunity to understand the pathophysiology of this enigmatic obstetrical compli- cation. The project will capitalize on high resolution exposure and health outcome data as it aims to develop a birth linkage database that will include hospital discharges linked to both stillbirths and live births-infant deaths to resident women in California, Florida, Massachusetts, Michigan, and South Carolina (estimated 16 million births, including 155,000 abruption cases) between 2000–2016. For each pregnancy we will assign average daily ambient exposure to fine particulate matter with an aerodynamic diameter ≤2.5 µm (PM2.5), its constituents (elemental carbon and organic carbon, sulfate, nitrate, and ammonium), as well as gaseous pollutants (nitrogen dioxide and ozone), using spatiotemporally resolved models that predict exposure for each residential location. We will also assign every residence with average daily temperature, humid- ity, dew point, heat waves, and atmospheric air pressure. The project will focus on disentangling the relative contributions of ambient air pollution and weather-related conditions on acute abruption through a bi-directional, time-stratified case- crossover design, and those of abruptions with chronic underpinnings using a cohort design. We will apply distributed lag linear and non-linear models to identify critical windows of exposure, Bayesian Kernel Machine Regression to characterize associations based on multi-pollutant exposures, and causal interaction-mediation decomposition analyses through ischemic placental disease (preeclampsia, fetal growth disturbances). We will consider individual– and neighborhood–level con- founders derived from residential census tracts. All associations will be corrected for simultaneous exposure and outcome misclassification, as well as for exposure measurement error owing to maternal residential mobility through a regression calibration approach. The ubiquitous nature of air pollution and weather exposures and their potential impact on adverse perinatal outcomes, as well as the preliminary data supporting the associations, presents unprecedented opportunities to address implications of the adverse impact of air pollution and weather-related exposures on placental abruption and related obstetrical complications. This project aligns with 2 major critical areas of research–Co-exposures, and Data Sci- ence and Big Data–outlined in the 2018-2023 strategic goals of NIH-National Institute of Environmental Health Sciences.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Cande V. Ananth其他文献

38: Quantitative activity levels and gestational age at delivery: A prospective cohort study among nulliparous women
  • DOI:
    10.1016/j.ajog.2019.11.054
  • 发表时间:
    2020-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Whitney A. Booker;Etoroabasi E. Ekpe;Yuan Zhang;Cande V. Ananth;Roxane Handal-Orefice;Vanessa Nieto;Cynthia Gyamfi-Bannerman
  • 通讯作者:
    Cynthia Gyamfi-Bannerman
Preeclampsia risk related to maternal smoking: effect modification by body-mass index and gestational weight gain
  • DOI:
    10.1016/j.ajog.2022.11.1182
  • 发表时间:
    2023-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Morgan C. Dunn;Cande V. Ananth;Todd J. Rosen
  • 通讯作者:
    Todd J. Rosen
1065 The risk of mortality from cardiovascular disease differs depending on the mode of delivery
  • DOI:
    10.1016/j.ajog.2023.11.1092
  • 发表时间:
    2024-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Gabriella Lobitz;Emily B. Rosenfeld;Rachel Lee;Deepika Sagaram;Cande V. Ananth
  • 通讯作者:
    Cande V. Ananth
<strong>52</strong> Short term risk of cardiovascular disease complications differs depending on the mode of delivery
  • DOI:
    10.1016/j.ajog.2023.11.072
  • 发表时间:
    2024-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Gabriella Lobitz;Emily B. Rosenfeld;Rachel Lee;Deepika Sagaram;Cande V. Ananth
  • 通讯作者:
    Cande V. Ananth
strong52/strong Short term risk of cardiovascular disease complications differs depending on the mode of delivery
<强52/强> 心血管疾病并发症的短期风险因分娩方式而异
  • DOI:
    10.1016/j.ajog.2023.11.072
  • 发表时间:
    2024-01-01
  • 期刊:
  • 影响因子:
    8.400
  • 作者:
    Gabriella Lobitz;Emily B. Rosenfeld;Rachel Lee;Deepika Sagaram;Cande V. Ananth
  • 通讯作者:
    Cande V. Ananth

Cande V. Ananth的其他文献

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{{ truncateString('Cande V. Ananth', 18)}}的其他基金

Ambient Air Pollution, Weather, and Placental Abruption (APWA)
环境空气污染、天气和胎盘早剥 (APWA)
  • 批准号:
    10649518
  • 财政年份:
    2021
  • 资助金额:
    $ 64.27万
  • 项目类别:
Ambient Air Pollution, Weather, and Placental Abruption (APWA)
环境空气污染、天气和胎盘早剥 (APWA)
  • 批准号:
    10276251
  • 财政年份:
    2021
  • 资助金额:
    $ 64.27万
  • 项目类别:
Cardiovascular Health After Placental Abruption (CHAP)
胎盘早剥后的心血管健康 (CHAP)
  • 批准号:
    10677792
  • 财政年份:
    2020
  • 资助金额:
    $ 64.27万
  • 项目类别:
Cardiovascular Health After Placental Abruption (CHAP)
胎盘早剥后的心血管健康 (CHAP)
  • 批准号:
    10444976
  • 财政年份:
    2020
  • 资助金额:
    $ 64.27万
  • 项目类别:
Cardiovascular Health After Placental Abruption (CHAP)
胎盘早剥后的心血管健康 (CHAP)
  • 批准号:
    10238171
  • 财政年份:
    2020
  • 资助金额:
    $ 64.27万
  • 项目类别:
Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
胎盘早剥的触发因素——缺血性胎盘的病例交叉研究
  • 批准号:
    8324980
  • 财政年份:
    2010
  • 资助金额:
    $ 64.27万
  • 项目类别:
Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
胎盘早剥的触发因素——缺血性胎盘的病例交叉研究
  • 批准号:
    8514660
  • 财政年份:
    2010
  • 资助金额:
    $ 64.27万
  • 项目类别:
Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
胎盘早剥的触发因素——缺血性胎盘的病例交叉研究
  • 批准号:
    7983908
  • 财政年份:
    2010
  • 资助金额:
    $ 64.27万
  • 项目类别:
Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
胎盘早剥的触发因素——缺血性胎盘的病例交叉研究
  • 批准号:
    8701313
  • 财政年份:
    2010
  • 资助金额:
    $ 64.27万
  • 项目类别:
Triggers of Abruptio Placentae - A Case Crossover Study of an Ischemic Placental
胎盘早剥的触发因素——缺血性胎盘的病例交叉研究
  • 批准号:
    8141387
  • 财政年份:
    2010
  • 资助金额:
    $ 64.27万
  • 项目类别:

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造血分化的转录评估对急性淋巴细胞白血病的风险分层
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