Pharmacometrics and Analytical Chemistry Core

药物计量学和分析化学核心

• 批准号: 10487513
• 负责人: Jeremiah D Momper
• 金额: $ 20.06万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-10 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10487513
• 关键词: Address; Analytical Chemistry; Animal Model; Antibiotics; Basic Science; Biological Assay; Blood; Breast Feeding; Breastfed infant; Cerebrospinal Fluid; Clinical; Coupled; Data; Data Science; Development; Drug Kinetics; Education and Outreach; Environment; Goals; Hair shaft structure; High Pressure Liquid Chromatography; Human Milk; Infant; Infrastructure; Knowledge acquisition; Laboratories; Leadership; Liquid Chromatography; Measures; Meconium; Milk; Mothers; Parents; Pharmaceutical Preparations; Pharmacologic Substance; Pharmacology; Pharmacy Schools; Physiological; Plasma; Research Activity; Research Training; Resources; Sampling; Science; Secure; Spottings; Testing; Therapeutic Effect; Time; Tissues; Translational Research; Translations; Urine; Validation; Whole Blood; antimicrobial drug; base; cost effective; experience; innovation; instrumentation; laboratory facility; medical specialties; meetings; metabolomics; models and simulation; multidisciplinary; novel; pediatric department; pediatric pharmacology; pharmacokinetic model; pharmacometrics; physiologic model; pre-clinical; programs; tandem mass spectrometry

The Pharmacometrics and Analytical Chemistry Core (PACC) will further the goals of this multidisciplinary UC San Diego MPRINT CET proposal by conducting highly coordinated research activities with the Clinical, Basic Research and Data Science Projects and the Milk Analytics Core, with guidance from the Administrative Core. Precise, high quality translation and clinical pharmacokinetic (PK) data will be generated to help address hypotheses raised in each of the Projects. The infrastructure enabling the PACC lies in the established and highly productive UC San Diego Pediatric Pharmacology Laboratory (PPL) within the Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pediatrics. Specific Aims of the Clinical, Basic Science and Data Science Projects require quantification of antibiotics, their metabolites, and therapeutic effects markers in a variety of clinical and animal model matrices. The PACC is well qualified to conduct these quantitative assays and has experience with the small volumes and heterogeneous matrices associated with PK samples that will be generated by the Projects, including breastmilk. The PACC possesses prior and contemporary expertise in the processing of plasma, serum, whole blood, urine, cerebrospinal fluid, meconium, hair shaft, as well as all mammalian tissue types. Additionally, the PACC will continue to expand upon its capabilities to include quantification of drug metabolites in addition to their parent compounds. Quantification of drugs and metabolites in breast milk, plasma, and other matrices will be accomplished by LC-MS/MS and/or HPLC-UV. The PACC will also offer dedicated and specialized PK analysis to Project Leaders, including innovative PK modeling and simulation and physiologically-based PK (PBPK) modeling. Finally, the PACC will provide an optimal research and training environment in which to support the Clinical, Basic Science, and Translational Science Projects.

药物计量学和分析化学核心（PACC）将进一步实现这一多学科UC的目标 圣地亚哥MPRINT CET建议通过与临床，基础和临床研究中心进行高度协调的研究活动， 研究和数据科学项目和牛奶分析核心，由行政核心的指导。 将生成精确、高质量的翻译和临床药代动力学（PK）数据，以帮助解决 在每个项目中提出的假设。支持PACC的基础设施在于建立和 斯卡格斯学院内高效的加州大学圣地亚哥分校儿科药理学实验室（PPL） 药学和药学科学及儿科学系。临床、基础、 科学和数据科学项目需要量化抗生素、其代谢物和治疗药物， 在各种临床和动物模型基质中的效应标志物。反腐败委员会完全有资格进行这些工作， 定量分析，并具有与以下相关的小体积和异质基质的经验： 将由项目生成的PK样本，包括母乳。PACC拥有优先和 在血浆、血清、全血、尿液、脑脊液、胎粪处理方面的当代专业知识， 毛干，以及所有哺乳动物组织类型。此外，PACC将继续扩大其 除母体化合物外，还可对药物代谢物进行定量。定量 将通过LC-MS/MS和/或 HPLC-UV。PACC还将为项目负责人提供专门的PK分析，包括 创新的PK建模和模拟以及基于生理学的PK（PBPK）建模。最后，PACC将 提供最佳的研究和培训环境，以支持临床，基础科学， 翻译科学项目。