Spatially Resolved Analytical Chemistry: Magnetic Resonance and Magnetic Resonance Imaging of Materials and Processes.

空间分辨分析化学：材料和过程的磁共振和磁共振成像。

• 批准号: RGPIN-2022-04003
• 负责人: Balcom, Bruce
• 金额: $ 7.5万
• 依托单位: University of New Brunswick
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762404
• 关键词: Spatially; Resolved; Analytical; Chemistry; Magnetic

It is a scientific truth that new methods of measurement inevitably lead to new discoveries and new understanding. Our long term objective is to develop and explore Magnetic Resonance (MR) and Magnetic Resonance Imaging (MRI) as quantitative tools in the chemical and materials sciences. MRI is well established in clinical radiology; it can be similarly valuable in analytical and materials chemistry because it permits, in select systems, examination of chemical change both spatially and temporally resolved. Magnetic resonance spectroscopy, the premier analytical technique in chemical science, is a frequency domain technique. The MR and MRI methods we espouse are strongly oriented to the time domain, where one measures signal intensities and signal lifetimes. Quite naturally such MR techniques are often termed time domain MR. In MRI these same signal intensities and lifetimes yield contrast in an image.      In this Discovery grant program we will emphasize three areas of research, our short term objectives. (1) MR/MRI methods with a new style variable field magnet for the interrogation of complex functional structures including batteries. Variable field operation permits interrogation of different MR active nuclei, for example 1H, 19F and 7Li at constant frequency. New MR/MRI applications in the variable field magnet will include 3D printed high strength MR/MRI compatible metal pressure vessels. (2) Relaxation correlation measurements of materials, notably new T1-T2* and T1rho-T2* methods. These methods will permit analysis of systems heretofore inaccessible to relaxation correlation studies. These methods will permit rational control and understanding of the contrast in the MR/MRI studies of area 1. (3) New style permanent magnets based on simple, low cost NdFeB permanent magnets. A variety of small portable magnets will be developed for studies of chemical systems, including magnets with an imposed permanent magnetic field gradient for studies of spatially resolved velocity in tube flow for rheology.       The UNB MRI Centre is one of the best known MR/MRI of materials laboratories worldwide. It is also one of the largest and best equipped laboratories of its type. The broad appeal of the methodologies we continue to pioneer is most readily reflected by the wide range of academic and corporate research labs with whom we interact. In all areas of research proposed we are one of the top three labs in the world, and in many cases we lead internationally. We intend to develop and extend our lead. In all of our work, the development and application of MR and MRI methods to `challenging' materials systems and conditions will assist the development and application of MR/MRI, a multi billion dollar industry, in science and biomedicine.

新的测量方法必然导致新的发现和新的理解，这是一个科学真理。我们的长期目标是开发和探索磁共振（MR）和磁共振成像（MRI）作为化学和材料科学的定量工具。MRI在临床放射学中已得到广泛应用;它在分析和材料化学中也具有同样的价值，因为它允许在选定的系统中检查空间和时间分辨率的化学变化。磁共振波谱是一种频域分析技术，是化学科学中最重要的分析技术。我们支持的MR和MRI方法强烈地面向时域，其中一个测量信号强度和信号寿命。很自然地，这种MR技术通常被称为时域MR。在MRI中，这些相同的信号强度和寿命在图像中产生对比度。 在这个发现补助金计划中，我们将强调三个研究领域，我们的短期目标。(1)采用新型可变磁场磁体的MR/MRI方法，用于询问包括电池在内的复杂功能结构。可变场操作允许以恒定频率询问不同的MR活性核，例如1H、19 F和7 Li。可变场磁体的新MR/MRI应用将包括3D打印的高强度MR/MRI兼容金属压力容器。(2)材料的弛豫相关测量，特别是新的T1-T2* 和T1 rho-T2 * 方法。这些方法将允许系统的分析，迄今无法弛豫相关研究。（3）基于简单、低成本NdFeB永磁体的新型永磁体。将开发各种小型便携式磁体用于化学系统的研究，包括具有施加的永久磁场梯度的磁体，用于研究管流中的空间分辨速度以用于流变学。 UNB MRI中心是全球最知名的MR/MRI材料实验室之一，也是同类实验室中规模最大、设备最好的实验室之一。我们继续开拓的方法的广泛吸引力最容易反映在与我们互动的广泛的学术和企业研究实验室中。在所有研究领域，我们都是世界上三大实验室之一，在许多情况下，我们在国际上处于领先地位。在我们所有的工作中，MR和MRI方法的开发和应用将有助于MR/MRI的开发和应用，这是一个价值数十亿美元的产业，在科学和生物医学领域。