CMV Vaccines: Reinfection and Antigenic Variation
CMV 疫苗:再感染和抗原变异
基本信息
- 批准号:10488568
- 负责人:
- 金额:$ 49.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-16 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAfricaAntigenic VariationAsiaBehaviorBehavior TherapyChildClinicalCognitive TherapyComplexConceptionsCongenital AbnormalityCytomegalovirusCytomegalovirus InfectionsCytomegalovirus VaccinesDevelopmentDiseaseEpidemiologyExhibitsExposure toFetusFrequenciesHouseholdHumanImmuneImmunityImmunologicsIncidenceInfantInfectionInterruptionInterventionLeadLinkMaternally-Acquired ImmunityMothersNatural HistoryNewborn InfantNorthern EuropePerformancePopulationPregnancyPregnant WomenPrevalencePreventive vaccineProspective StudiesReportingResearch DesignRiskRisk FactorsRoleRubella virusSecondary toSelection BiasSeroprevalencesSourceSouth AmericaTestingTherapeutic InterventionTransplant RecipientsVaccinesVariantVirusVirus DiseasesWomanZika Virusadaptive immunitychronic infectioncongenital infectiondesigngenetic varianthearing impairmenthearing rangein uteroinfant infectionintrauterine infectionoffspringpregnantpreventpreventive interventionresponsetherapy designtransmission processviral transmission
项目摘要
Abstract:
Congenital human cytomegalovirus (cCMV) infection is the most common viral infection acquired in-utero and
a significant cause of neurodevelopmental abnormalities in infants and children. Although the development of
prophylactic vaccines to prevent or modify this intrauterine infection is a high priority, the unique epidemiology
of cCMV infections, particularly in highly seroimmune maternal populations presents a potential hurdle for
vaccines that will induce immunity similar to that following natural infection. Paradoxically, the rates of cCMV
infections are highest in maternal populations with the highest rates of seroimmunity. In addition, the incidence
of clinically apparent congenital infections and long term neurodevelopmental sequelae in these populations
are similar to those in populations with lower rates of maternal seroimmunity. In this application we will explore
the hypothesis that reinfections with new strains of CMV contributes significantly to the incidence of non-
primary maternal infections that result in cCMV infection and that the source of new strains of CMV are
household exposures, specifically young children. Our approach will be to identify sources of virus exposures,
introduce a cognitive-behavioral intervention to reduce the risks of these exposures, and to determine the
impact of this intervention on the prevalence of cCMV infections in a population of pregnant women with near
universal seroimmunity to CMV prior to conception.
摘要:
先天性人巨细胞病毒(cCMV)感染是最常见的宫内获得性病毒感染,
是婴儿和儿童神经发育异常的重要原因。的发展虽然
预防性疫苗,以防止或修改这种宫内感染是一个高度优先事项,独特的流行病学
cCMV感染,特别是在高度血清免疫的孕产妇人群中,
疫苗将诱导类似于自然感染后的免疫力。巧合的是,cCMV的发病率
血清免疫率最高的产妇感染率最高。此外,发病率
这些人群中临床明显的先天性感染和长期神经发育后遗症
与母体血清免疫率较低的人群相似。在这个应用程序中,我们将探索
假设CMV新毒株的再感染显著增加了非-
导致cCMV感染的原发性母体感染和新CMV毒株的来源是
家庭接触,特别是幼儿。我们的方法将是确定病毒暴露的来源,
引入认知行为干预,以降低这些风险,并确定
本研究旨在探讨这种干预措施对接近正常妊娠的孕妇人群中cCMV感染率的影响。
在怀孕前对CMV的普遍血清免疫。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William Jarvis Britt其他文献
William Jarvis Britt的其他文献
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{{ truncateString('William Jarvis Britt', 18)}}的其他基金
Tegument Envelope Protein Interactions in CMV Envelopment
CMV 包膜中的皮膜包膜蛋白相互作用
- 批准号:
10573700 - 财政年份:2022
- 资助金额:
$ 49.95万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation
CMV 疫苗:再感染和抗原变异
- 批准号:
10019411 - 财政年份:2019
- 资助金额:
$ 49.95万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation
CMV 疫苗:再感染和抗原变异
- 批准号:
10686167 - 财政年份:2019
- 资助金额:
$ 49.95万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation (Vision and auditory screening in infants born to women enrolled in ZIP)
CMV 疫苗:再感染和抗原变异(参加 ZIP 的妇女所生婴儿的视力和听觉筛查)
- 批准号:
9472616 - 财政年份:2017
- 资助金额:
$ 49.95万 - 项目类别:
Inflammation and Hearing Loss Following Congenital CMV Infection
先天性巨细胞病毒感染后的炎症和听力损失
- 批准号:
9759910 - 财政年份:2017
- 资助金额:
$ 49.95万 - 项目类别:
Inflammation and Hearing Loss Following Congenital CMV Infection
先天性巨细胞病毒感染后的炎症和听力损失
- 批准号:
10238050 - 财政年份:2017
- 资助金额:
$ 49.95万 - 项目类别:
HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment
HCMV miRNA 对病毒装配室的分泌和形成的调节
- 批准号:
9883699 - 财政年份:2016
- 资助金额:
$ 49.95万 - 项目类别:
HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment
HCMV miRNA 对病毒装配室的分泌和形成的调节
- 批准号:
9250666 - 财政年份:2016
- 资助金额:
$ 49.95万 - 项目类别:
Congenital CMV and CNS Infection Mechanisms of Protective Immunity
先天性巨细胞病毒和中枢神经系统感染的保护性免疫机制
- 批准号:
8450754 - 财政年份:2011
- 资助金额:
$ 49.95万 - 项目类别:
Congenital CMV and CNS Infection Mechanisms of Protective Immunity
先天性巨细胞病毒和中枢神经系统感染的保护性免疫机制
- 批准号:
10398817 - 财政年份:2011
- 资助金额:
$ 49.95万 - 项目类别:
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