Inflammation and Hearing Loss Following Congenital CMV Infection
先天性巨细胞病毒感染后的炎症和听力损失
基本信息
- 批准号:10238050
- 负责人:
- 金额:$ 61.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAffectAnimal ModelAnimalsAntiviral AgentsAuditoryAuditory systemAutopsyBirthBrazilCell physiologyCellsCellular MorphologyCellular TropismCharacteristicsChildChild HealthClinicalClinical TrialsCochleaCochlear nucleusCytomegalovirusCytomegalovirus InfectionsCytopathologyDevelopmentDiseaseExhibitsGeneticGoalsHair CellsHearingHematogenous SpreadHerpesviridaeHumanImmune responseIndiaInfantInfectionInfiltrationInflammationInner Ear InfectionInvestigationLabyrinthLesionLifeLinkLive BirthLiverMediatingMediator of activation proteinModelingMononuclearMorphologyMusNewborn InfantOrgan of CortiOutcomePathway interactionsPatientsPatternPerinatal InfectionPeripheralReportingRoleRouteSecondary toSensorineural Hearing LossSiteSpecimenSpleenStructureTherapeuticTranslatingViralViremiaVirusVirus DiseasesVirus Replicationadaptive immune responseclinical investigationcongenital cytomegaloviruscongenital infectionfollow-uphearing impairmentinfant infectioninsightintraperitonealmouse modelneonatal infectionneuron lossnovel therapeutic interventionperinatal periodprevent hearing lossprimary endpointprogressive hearing lossspiral gangliontargeted treatmentvirology
项目摘要
Abstract:
Hearing loss associated with congenital human cytomegalovirus (HCMV) infection, a relatively
frequent perinatal infection, accounts for nearly 25% of all causes of hearing loss in infants and
children in the US. The mechanisms of disease caused by infection of the inner ear by this
large herpesvirus are unknown, primarily because of hurdles inherent in the investigation of the
inner ear in humans. We have developed an informative murine model of hearing loss in which
newborn mice are infected peripherally and not intracranially with the closely related murine
CMV. In this model, about 30-50% of infected mice develop sensorineural hearing loss and a
significant number of mice with hearing loss exhibit progression in hearing loss, a clinically
important feature of hearing loss in infants with HCMV associated hearing loss. Our findings
strongly argue that virus-induced inflammation and not direct viral cytopathology is responsible
for hearing loss and progressive hearing loss in this model. Our studies will explore this
hypothesis by defining mechanisms of damage to the developing auditory system and hearing
loss in animals associated with CMV-induced inflammation of the inner ear. Results from these
studies will guide investigation into mechanisms of hearing loss in infants and children with
HCMV associated hearing loss and identify therapeutic approaches that can be translated into
treatment and prevention of hearing loss in CMV infected infants.
摘要:
先天性人巨细胞病毒(HCMV)感染相关的听力损失,
频繁的围产期感染,占婴儿听力损失所有原因的近25%,
美国的孩子。内耳感染引起的疾病的机制,
大疱疹病毒是未知的,主要是因为在调查中固有的障碍,
人类的内耳我们开发了一种信息丰富的听力损失小鼠模型,其中
新生小鼠外周感染而非颅内感染密切相关的鼠
巨细胞病毒在该模型中,约30-50%的感染小鼠发展为感音神经性听力损失,
相当数量的听力损失小鼠表现出听力损失的进展,
HCMV相关性听力损失婴儿听力损失的重要特征。我们的研究结果
强烈认为病毒诱导的炎症而不是直接的病毒细胞病理学是负责的
听力损失和渐进性听力损失。我们的研究将探讨这一点
通过定义发育中的听觉系统和听力损伤的机制,
与CMV诱导的内耳炎症相关的动物损失。从这些
研究将指导对婴儿和儿童听力损失机制的调查,
HCMV相关的听力损失,并确定治疗方法,可以转化为
CMV感染婴儿听力损失的治疗和预防。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cytomegalovirus Infection and Inflammation in Developing Brain.
- DOI:10.3390/v13061078
- 发表时间:2021-06-04
- 期刊:
- 影响因子:0
- 作者:Krstanović F;Britt WJ;Jonjić S;Brizić I
- 通讯作者:Brizić I
NK/ILC1 cells mediate neuroinflammation and brain pathology following congenital CMV infection.
- DOI:10.1084/jem.20201503
- 发表时间:2021-05-03
- 期刊:
- 影响因子:0
- 作者:Kveštak D;Juranić Lisnić V;Lisnić B;Tomac J;Golemac M;Brizić I;Indenbirken D;Cokarić Brdovčak M;Bernardini G;Krstanović F;Rožmanić C;Grundhoff A;Krmpotić A;Britt WJ;Jonjić S
- 通讯作者:Jonjić S
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
William Jarvis Britt其他文献
William Jarvis Britt的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('William Jarvis Britt', 18)}}的其他基金
Tegument Envelope Protein Interactions in CMV Envelopment
CMV 包膜中的皮膜包膜蛋白相互作用
- 批准号:
10573700 - 财政年份:2022
- 资助金额:
$ 61.8万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation
CMV 疫苗:再感染和抗原变异
- 批准号:
10019411 - 财政年份:2019
- 资助金额:
$ 61.8万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation
CMV 疫苗:再感染和抗原变异
- 批准号:
10488568 - 财政年份:2019
- 资助金额:
$ 61.8万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation
CMV 疫苗:再感染和抗原变异
- 批准号:
10686167 - 财政年份:2019
- 资助金额:
$ 61.8万 - 项目类别:
CMV Vaccines: Reinfection and Antigenic Variation (Vision and auditory screening in infants born to women enrolled in ZIP)
CMV 疫苗:再感染和抗原变异(参加 ZIP 的妇女所生婴儿的视力和听觉筛查)
- 批准号:
9472616 - 财政年份:2017
- 资助金额:
$ 61.8万 - 项目类别:
Inflammation and Hearing Loss Following Congenital CMV Infection
先天性巨细胞病毒感染后的炎症和听力损失
- 批准号:
9759910 - 财政年份:2017
- 资助金额:
$ 61.8万 - 项目类别:
HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment
HCMV miRNA 对病毒装配室的分泌和形成的调节
- 批准号:
9883699 - 财政年份:2016
- 资助金额:
$ 61.8万 - 项目类别:
HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment
HCMV miRNA 对病毒装配室的分泌和形成的调节
- 批准号:
9250666 - 财政年份:2016
- 资助金额:
$ 61.8万 - 项目类别:
Congenital CMV and CNS Infection Mechanisms of Protective Immunity
先天性巨细胞病毒和中枢神经系统感染的保护性免疫机制
- 批准号:
8450754 - 财政年份:2011
- 资助金额:
$ 61.8万 - 项目类别:
Congenital CMV and CNS Infection Mechanisms of Protective Immunity
先天性巨细胞病毒和中枢神经系统感染的保护性免疫机制
- 批准号:
10398817 - 财政年份:2011
- 资助金额:
$ 61.8万 - 项目类别:
相似海外基金
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 61.8万 - 项目类别:
Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
- 批准号:
2301846 - 财政年份:2023
- 资助金额:
$ 61.8万 - 项目类别:
Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 61.8万 - 项目类别:
Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
- 批准号:
23K16076 - 财政年份:2023
- 资助金额:
$ 61.8万 - 项目类别:
Grant-in-Aid for Early-Career Scientists