Animal Models & Imaging Facility (AMIF)

动物模型

• 批准号: 10487415
• 负责人: Karen H Martin
• 金额: $ 5.48万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10487415
• 关键词: Address; Animal Cancer Model; Animal Disease Models; Animal Model; Animals; Area; Award; Biomedical Research; Cancer Biology; Cancer Model; Cancer Patient; Cells; Centers of Research Excellence; Clinical Research; Collaborations; Complex; Core Facility; Data Analyses; Development; Disease Progression; Education; Electron Spin Resonance Spectroscopy; Ensure; Equipment; Event; Experimental Designs; Extramural Activities; Flow Cytometry; Funding; Goals; Health; Image; Institution; Investments; Journals; Magnetic Resonance Imaging; Malignant Neoplasms; Mentors; Modeling; Monitor; Neoplasm Metastasis; Optics; Patients; Postdoctoral Fellow; Pre-Clinical Model; Procedures; Process; Program Sustainability; Publications; Radiation therapy; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Rodent; Sampling; Series; Services; Signal Pathway; Students; System; Technology; Time; Training; Training Support; Translational Research; Tumor Biology; Universities; West Virginia; X-Ray Computed Tomography; Xenograft Model; animal imaging; cancer care; clinically relevant; design; efficacy testing; experience; extracellular; health disparity; human model; imaging facilities; imaging study; imaging system; improved; in vivo; instrumentation; member; microCT; molecular imaging; mouse model; new technology; non-invasive imaging; novel; novel therapeutics; operation; patient derived xenograft model; pre-clinical; pre-clinical research; programs; recruit; single cell analysis; success; therapeutic target; tool; treatment response; tumor; tumor growth; tumor microenvironment; tumor progression; tumorigenesis

PROJECT SUMMARY/ABSTRACT The Animal Models & Imaging Facility (AMIF) provides state-of-the-art, preclinical molecular imaging services for biomedical research at West Virginia University. Animal models of disease are a critical tool for the translational research projects that promote understanding of the factors that influence the progression of disease and the impact of potential therapeutic targets. Cancer researchers, in particular, need to be able to study tumor growth and metastasis in the context of the microenvironment in real time and in living animals to determine the events that initiate tumorigenesis, promote cancer progression or impact response to treatment. As part of the Tumor Microenvironment Center of Biomedical Research Excellence (TME CoBRE), the AMIF has expanded its imaging and preclinical treatment capabilities with the addition of new equipment for radiation therapy, electron paramagnetic resonance and magnetic resonance imaging, and for high-resolution micro computed tomography. The AMIF is the only facility on campus that can offer these longitudinal, non-invasive imaging studies with sufficient resolution for working in small animal models. The long-term goals of this core are to (1) establish novel treatment and imaging resources in an existing core facility to support translational research projects targeting the tumor microenvironment and (2) provide training and support for investigators using preclinical models to study cancer biology. This TME CoBRE-supported core will synergize with other Institutional Development Award (IDeA)-funded projects including other CoBRE projects, the IDeA Network of Biomedical Research Excellence (INBRE), and the IDeA Clinical and Translational Research Award (IDeA-CTR) to enhance research competitiveness, improve therapy, and address health disparities, particularly in cancer. The AMIF provides opportunities for collaboration with other Centers at WVU resulting in the broadest impact of CoBRE investment. Further, it is integrated with the Patient-Derived Xenograft Core Facility in this TME CoBRE application through the study of mouse models using primary patient samples. In addition, it is highly connected to the Flow Cytometry Single Cell Analysis Core Facility that will provide downstream analysis of cells recovered from xenograft models. The AMIF is committed to mentoring and participates in the Technology Seminar Series in partnership with the other CoBRE Cores to enhance both education and collaboration across the CoBRE- supported initiatives.

项目总结/摘要 动物模型和成像设施（AMIF）提供最先进的临床前分子成像服务 在西弗吉尼亚大学进行生物医学研究。疾病的动物模型是一个重要的工具， 翻译研究项目，促进对影响发展的因素的理解 疾病和潜在治疗靶点的影响。癌症研究人员尤其需要能够 在真实的时间和活体动物的微环境中研究肿瘤生长和转移， 确定引发肿瘤发生、促进癌症进展或影响治疗反应的事件。 作为生物医学研究卓越肿瘤微环境中心（TME CoBRE）的一部分，AMIF 通过增加新的放射设备，扩大了其成像和临床前治疗能力 电子顺磁共振和磁共振成像，以及用于高分辨率显微成像。 计算机断层扫描。AMIF是校园内唯一一个可以提供这些纵向，非侵入性 具有足够分辨率的成像研究，用于在小动物模型中工作。这一核心的长期目标 （1）在现有的核心设施中建立新的治疗和成像资源，以支持翻译 针对肿瘤微环境的研究项目;（2）为研究人员提供培训和支持 使用临床前模型来研究癌症生物学。这个TME CoBRE支持的核心将与其他 机构发展奖（IDEA）资助的项目，包括其他COBRE项目，IDEA网络 生物医学研究卓越奖（INBRE）和IDEA临床和转化研究奖（IDEA-CTR） 提高研究竞争力，改善治疗，解决健康差距，特别是癌症。 AMIF提供了与西弗吉尼亚大学其他中心合作的机会，从而产生了最广泛的影响， Cobre投资。此外，它与TME CoBRE中的患者源性异种移植核心设施相结合 通过使用主要患者样品的小鼠模型的研究来应用。此外，它还高度连接 流式细胞术单细胞分析核心设施，将提供回收细胞的下游分析 异种移植模型。AMIF致力于指导和参与技术研讨会系列 与其他CoBRE核心合作，加强整个CoBRE的教育和合作， 支持的举措。