Data Management and Analysis Core

项目摘要/摘要 数据和生命科学核心(DLSC)在内布拉斯加州综合研究中心的广泛、长期目标 生物分子通信(CIBC)将成为生物医学数据科学的关键、可持续资源 以及内布拉斯加大学的数据管理专业知识、服务和教育。这项研究进行了 加拿大帝国商业银行的调查人员将继续创建大型、复杂的数据集，特别是对于 研究人员的项目涉及高通量生物数据和分子生物学数据。恰如其分 这些数据集的实验设计、数据生成和后续分析需要分析和 计算专长、获得科学设备和相关技术专长、高吞吐量 用于数据管理的计算和资源。协调获得这类服务的成本往往很高 对于个别实验室来说，这是不直观的。许多生物医学研究人员面临的另一个障碍包括 与CIBC有关联的是研究数据和研究成果的及时和全面共享 合作者、利益相关者和公众。为了解决这些问题，加拿大帝国商业银行将继续支持DLSC。DLSC 提供硬件、软件和实验设计、生物信息学、计算生物学、 统计、计算机科学、数据管理和高级网络基础设施 更广泛的大学社区。到目前为止，DLSC已经推出了一个用于数据传输、托管和共享的Web门户 通过Globus和内布拉斯加大学的荷兰计算中心；发起与CIBC的合作 研究人员提供演示文稿和出版物；提供访问分析软件的途径；并主办 培训和劳动力发展机会。DLSC第二阶段的近期目标是扩展和 加强核心的数据科学和数据管理基础设施、服务、专业知识和教育 为CIBC调查人员和中心的总体目标和长期可持续性提供支持的方案。这 将通过四个目标实现：1)扩展现有的计算平台，用于数据存储、分析和 管理包括对生物分子成像实验的支持以及与研究空间的整合 平台，2)通过发起与整个大学的人员合作来促进核心可持续性 内布拉斯加州校园，支持需要数据专业知识的复杂、跨学科生物医学项目 科学和数据管理，3)通过在CIBC上的合作，在CIBC研究中发挥关键的、可持续的作用 项目，既是与CIBC相关的研究出版物的作者，也是随后的 内部和外部研究资金的建议，以及4)教育CIBC成员关于数据的作用 化学和生化研究中的科学，实验数据的潜力和注意事项，以及开始- 用于数据预处理和分析的ART资源和管道。DSLC将继续利用现有的 内布拉斯加州大学的专业知识，雇佣所需的专业知识，并建立长期的核心可持续性。

PROJECT SUMMARY/ABSTRACT The broad, long-term goal of the Data and Life Sciences Core (DLSC) within the Nebraska Center for Integrated Biomolecular Communication (CIBC) is to serve as a critical, sustainable resource for biomedical data science and data management expertise, service, and education at the University of Nebraska. The research performed by CIBC investigators will continue to result in the creation of large, complex data sets, particularly for those researchers with projects involving high-throughput biological data and molecular biology data. Proper experimental design, data generation, and subsequent analyses of these data sets requires analytical and computational expertise, access to scientific equipment and relevant technical expertise, high-throughput computing, and resources for data management. Coordinated access to such services is often cost prohibitive and nonintuitive for individual laboratories. Another obstacle faced by many biomedical researchers, including those affiliated with CIBC, is the timely and comprehensive sharing of research data and research findings with collaborators, stakeholders, and the public. To address these issues, CIBC will continue to support DLSC. DLSC provides hardware, software, and expertise in experimental design, bioinformatics, computational biology, statistics, computer science, data management, and advanced cyberinfrastructure to CIBC investigators and the wider university community. To date, DLSC has launched a web portal for data transfer, hosting, and sharing through Globus and the University of Nebraska’s Holland Computing Center; initiated collaborations with CIBC researchers leading to presentations and publications; provided access to analytical software; and hosted training and workforce development opportunities. The immediate goal of DLSC for Phase 2 is to expand and strengthen the core’s data science and data management infrastructure, services, expertise, and educational programming in support of CIBC investigators and the Center’s overall goals and long-term sustainability. This will be achieved through four aims: 1) expand an existing computational platform for data storage, analysis, and management to include support for biomolecular imaging experiments and integration with the Research Space platform, 2) promote core sustainability by initiating collaborations with personnel across the University of Nebraska campuses to enable complex, interdisciplinary biomedical projects that require expertise in data science and data management, 3) serve a critical, sustainable role in CIBC research by collaborating on CIBC projects, both as authors on research publications relevant to CIBC and as investigators on subsequent proposals for internal and external research funding, and 4) educate CIBC members about the role of data science in chemical and biochemical research, the potential and caveats of experimental data, and start-of-the- art resources and pipelines for data preprocessing and analysis. DSLC will continue to capitalize on existing expertise at the University of Nebraska, hire needed expertise, and build long-term core sustainability.