Data Management and Analysis Core

摘要 将由内布拉斯加州集成生物分子通讯中心(CIBC)进行的研究 调查人员将创建大型、复杂的数据集，特别是对于那些具有 元基因组学、代谢组学和蛋白质组学方面的项目。适当的实验设计、数据生成和 对这些数据集的后续分析将需要分析和计算专业知识，获得科学 设备和相关技术专长，以及大容量、高速计算设施。协调一致 对于个别实验室来说，获得这种服务的成本往往令人望而却步，而且不直观。另一个障碍 许多生物医学研究人员，包括那些隶属于CIBC的人，面临的是及时和 与合作者、利益相关者和 普罗大众。为了解决这些问题，加拿大帝国商业银行将支持数据管理和分析核心 (DMAC)设施。DMAC设施的长期目标是建立一个关键的、可持续的资源，用于 生物信息学和分析支持，而其近期目标是开发和实施硬件、软件、 和高通量生物/化学数据方面的专业知识，从多类型数据管理到综合统计 分析。DMAC将通过四个具体目标为CIBC调查人员提供服务：1)设计和实施 用于数据管理的计算平台-包括适当的文档、长期备份和 基本数据分析-用于CIBC调查人员进行的实验室实验；2)建立 启动与DMAC人员的协作以支持复杂的跨学科项目，这些项目可能需要 在实验设计、统计方法和解释方面的专业知识；3)在以下方面发挥关键、可持续的作用 通过作为研究合作者参与建议的中心项目进行CIBC研究，详见 应用，作为生物信息学的教育者，作为与CIBC相关的出版物的作者，以及作为联合 对内部和外部资金的后续提案进行调查；以及4)教育CIBC成员 关于大规模组学数据在化学和生化研究中的作用，潜在的和警告 这类数据，以及已建立的用于基因组数据预处理和分析的管道，并便利使用 这样的技术在CIBC项目中。DMAC设施将为中心成员提供资源和 解决跨学科和跨学科研究问题的专业知识，重点是了解化学和 生化通讯途径在公共卫生中的应用。通过DMAC，CIBC成员将 接受来自博士级别的生物医学科学家的个性化帮助，并与 核心。CIBC成员还将受益于教育机会，这将有助于建立他们的知识 以生物医学组学、计算和分析为基础。DMAC将利用现有的专业知识在 内布拉斯加州大学林肯分校，聘请所需的专业知识，并与荷兰计算中心合作 现有的计算设施，在林肯和奥马哈都有设施。

ABSTRACT The research to be performed by Nebraska Center for Integrated Biomolecular Communication (CIBC) investigators will result in the creation of large, complex datasets, particularly for those researchers with projects in metagenomics, metabolomics, and proteomics. Proper experimental design, data generation, and subsequent analyses of these datasets will require analytical and computational expertise, access to scientific equipment and relevant technical expertise, and large capacity, high-speed computing facilities. Coordinated access to such services is often cost prohibitive and non-intuitive for individual laboratories. Another obstacle faced by many biomedical researchers, including those affiliated with the CIBC, is the timely and comprehensive sharing of research data and research findings with collaborators, stakeholders, and the general public. To address these issues, the CIBC will support a Data Management and Analysis Core (DMAC) facility. The DMAC facility's long-term objective is to establish a critical, sustainable resource for bioinformatics and analytical support, while its near-term goal is to develop and implement hardware, software, and expertise in high-throughput bio/chemical data, from multi-type data management to integrative statistical analyses. The DMAC will serve CIBC investigators through four specific aims: 1) Design and implement a computational platform for data management - including appropriate documentation, long-term backup, and basic data analysis - for laboratory experiments conducted by CIBC investigators; 2) Establish a process for initiating collaborations with DMAC personnel to enable complex, interdisciplinary projects which may require expertise in experimental design, statistical methods, and interpretation; 3) Serve a critical, sustainable role in CIBC research by contributing as research collaborators on proposed center projects as detailed in this application, as educators in bioinformatics, as authors on publications relevant to the CIBC, and as co- investigators on subsequent proposals for both internal and external funding; and 4) Educate CIBC members about the role of large-scale omics data in chemical and biochemical research, the potential and caveats of such data, and the established pipelines for omic data preprocessing and analysis and facilitate the use of such techniques in CIBC projects. The DMAC facility will provide Center members with the resources and expertise to address inter- and transdisciplinary research questions focused on understanding chemical and biochemical communication pathways for applications in public health. Through the DMAC, CIBC members will receive individualized assistance from and in collaboration with Ph.D.-level biomedical scientists within the core. CIBC members will also benefit from educational opportunities, which will help build their knowledge base in biomedical omics, computation, and analysis. The DMAC will capitalize on existing expertise at the University of Nebraska-Lincoln, hire needed expertise, and partner with the Holland Computing Center, an existing computing facility with facilities in both Lincoln and Omaha.