Data Management and Analysis Core

项目总结/摘要 内布拉斯加州集成中心内的数据和生命科学核心（DLSC）的广泛长期目标是 生物分子通信（CIBC）是生物医学数据科学的关键，可持续的资源 以及内布拉斯加大学的数据管理专业知识、服务和教育。展开的研究而产生 CIBC的调查人员将继续导致创建大型，复杂的数据集，特别是对于那些 研究人员的项目涉及高通量生物数据和分子生物学数据。适当 实验设计、数据生成和这些数据集的后续分析需要分析和 计算专门知识，获得科学设备和相关技术专门知识，高通量 计算和用于数据管理的资源。协调获得这些服务的费用往往过高 并且对于单个实验室来说是非直观的。许多生物医学研究人员面临的另一个障碍，包括 与CIBC有联系的机构，及时和全面地分享研究数据和研究成果， 合作者、利益相关者和公众。为了解决这些问题，CIBC将继续支持DLSC。DLSC 提供硬件，软件和实验设计，生物信息学，计算生物学， 统计，计算机科学，数据管理和先进的网络基础设施，CIBC调查人员和 更广泛的大学社区。到目前为止，DLSC已经推出了一个用于数据传输、托管和共享的门户网站 通过Globus和内布拉斯加大学的荷兰计算中心;发起与CIBC的合作 研究人员导致介绍和出版物;提供使用分析软件的机会;并主持 培训和劳动力发展机会。DLSC第二阶段的近期目标是扩大和 加强核心的数据科学和数据管理基础设施，服务，专业知识和教育 支持CIBC调查人员和中心的总体目标和长期可持续性的规划。这 将通过四个目标实现：1）扩展现有的计算平台，用于数据存储，分析， 管理，包括支持生物分子成像实验和与研究空间的整合 平台，2）通过与整个大学的人员开展合作，促进核心可持续性 内布拉斯加州的校园，使复杂的，跨学科的生物医学项目，需要在数据方面的专业知识 科学和数据管理，3）通过与CIBC合作，在CIBC研究中发挥关键的可持续作用 作为CIBC相关研究出版物的作者和后续研究的研究者， 内部和外部研究资金的建议，以及4）教育CIBC成员关于数据的作用 化学和生物化学研究的科学，实验数据的潜力和注意事项，以及 用于数据预处理和分析的艺术资源和管道。DSLC将继续利用现有的 在内布拉斯加大学的专业知识，聘请所需的专业知识，并建立长期的核心可持续性。

PROJECT SUMMARY/ABSTRACT The broad, long-term goal of the Data and Life Sciences Core (DLSC) within the Nebraska Center for Integrated Biomolecular Communication (CIBC) is to serve as a critical, sustainable resource for biomedical data science and data management expertise, service, and education at the University of Nebraska. The research performed by CIBC investigators will continue to result in the creation of large, complex data sets, particularly for those researchers with projects involving high-throughput biological data and molecular biology data. Proper experimental design, data generation, and subsequent analyses of these data sets requires analytical and computational expertise, access to scientific equipment and relevant technical expertise, high-throughput computing, and resources for data management. Coordinated access to such services is often cost prohibitive and nonintuitive for individual laboratories. Another obstacle faced by many biomedical researchers, including those affiliated with CIBC, is the timely and comprehensive sharing of research data and research findings with collaborators, stakeholders, and the public. To address these issues, CIBC will continue to support DLSC. DLSC provides hardware, software, and expertise in experimental design, bioinformatics, computational biology, statistics, computer science, data management, and advanced cyberinfrastructure to CIBC investigators and the wider university community. To date, DLSC has launched a web portal for data transfer, hosting, and sharing through Globus and the University of Nebraska’s Holland Computing Center; initiated collaborations with CIBC researchers leading to presentations and publications; provided access to analytical software; and hosted training and workforce development opportunities. The immediate goal of DLSC for Phase 2 is to expand and strengthen the core’s data science and data management infrastructure, services, expertise, and educational programming in support of CIBC investigators and the Center’s overall goals and long-term sustainability. This will be achieved through four aims: 1) expand an existing computational platform for data storage, analysis, and management to include support for biomolecular imaging experiments and integration with the Research Space platform, 2) promote core sustainability by initiating collaborations with personnel across the University of Nebraska campuses to enable complex, interdisciplinary biomedical projects that require expertise in data science and data management, 3) serve a critical, sustainable role in CIBC research by collaborating on CIBC projects, both as authors on research publications relevant to CIBC and as investigators on subsequent proposals for internal and external research funding, and 4) educate CIBC members about the role of data science in chemical and biochemical research, the potential and caveats of experimental data, and start-of-the- art resources and pipelines for data preprocessing and analysis. DSLC will continue to capitalize on existing expertise at the University of Nebraska, hire needed expertise, and build long-term core sustainability.