LIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomes

LIVOPT——肝硬化——优化患者结果的预测

基本信息

  • 批准号:
    10490243
  • 负责人:
  • 金额:
    $ 63.51万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-30 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT ABSTRACT Cirrhosis is a leading cause of mortality in the United States (US), diagnosed in millions of people and resulting in over 40,000 deaths each year, predominately in older people. These patients are at higher risk of serious complications (e.g. infection, ascites, hepatic encephalopathy), hospitalization and death. Little is known about the epidemiology and disease progression and older patients are more vulnerable and might have different risk profiles. The clinical challenge is to accurately and early predict who is at highest risk for requiring hospitalization and/or death and understanding how this might be different in older versus younger adults. . One barrier to date has been the lack of an epidemiologically representative patient sample that captures those with cirrhosis and goes beyond one health system, as many data repositories are skewed or limited: CMS only captures elderly and those with debility, NIS does not allow longitudinal observation, UNOS represents less than one percent of those with cirrhosis. Hence, we will build on our previous work to use a unique dataset, the Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN). CAPriCORN captures the electronic health records (EHR) from nine health systems from 2011-present (incl. academic center, county, VA and private), catching most of the diverse patient population in the greater Chicago metropolitan area, namely ~160,000 patients with liver cirrhosis. The dataset is extensive, allowing the use of traditional (e.g., regression) and novel analytical techniques (e.g. deep learning) to pursue the aims of the study. We aim to model cirrhosis progression in the elderly and to predict the risk of hospitalization and death in older patients with cirrhosis. We also aim to perform sub-group analyses focusing on race and socioeconomic factors in the elderly. The impact of accurate and early prediction of mortality and hospitalization risk in elderly patients with cirrhosis allows for targeted interventions of the most vulnerable patients to improve outcomes.
项目摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Daniela P Ladner其他文献

Transforming the Future of Surgeon-Scientists
改变外科医生科学家的未来
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    9
  • 作者:
    Daniela P Ladner;Allan M. Goldstein;Tim Billiar;Andrew M Cameron;Darren R Carpizo;Daniel I Chu;Craig M Coopersmith;Ronald P DeMatteo;Sandy Feng;Katherine A Gallagher;W. Gillanders;B. Lal;G. Lipshutz;Annie Liu;Ronald V. Maier;E. Mittendorf;Arden M. Morris;J. Sicklick;O. Velazquez;Bryan A. Whitson;Lee G Wilke;Sam S Yoon;Martha A. Zeiger;Diana L Farmer;E. S. Hwang
  • 通讯作者:
    E. S. Hwang

Daniela P Ladner的其他文献

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{{ truncateString('Daniela P Ladner', 18)}}的其他基金

Natural history, risk prediction and cost of cirrhosis in insured Americans.
受保美国人的肝硬化自然史、风险预测和费用。
  • 批准号:
    10346703
  • 财政年份:
    2022
  • 资助金额:
    $ 63.51万
  • 项目类别:
Natural history, risk prediction and cost of cirrhosis in insured Americans.
受保美国人的肝硬化自然史、风险预测和费用。
  • 批准号:
    10557845
  • 财政年份:
    2022
  • 资助金额:
    $ 63.51万
  • 项目类别:
The Northwestern Summer Research Program for Medical Students
西北医学生夏季研究计划
  • 批准号:
    10090216
  • 财政年份:
    2021
  • 资助金额:
    $ 63.51万
  • 项目类别:
LIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomes
LIVOPT——肝硬化——优化患者结果的预测
  • 批准号:
    10666608
  • 财政年份:
    2021
  • 资助金额:
    $ 63.51万
  • 项目类别:
The Northwestern Summer Research Program for Medical Students
西北医学生夏季研究计划
  • 批准号:
    10391427
  • 财政年份:
    2021
  • 资助金额:
    $ 63.51万
  • 项目类别:
Transplant Regimen Adherence for Kidney Recipients by Engaging Information Technologies: The TAKE IT Trial
通过利用信息技术提高肾受者的移植方案依从性:TAKE IT 试验
  • 批准号:
    9309767
  • 财政年份:
    2017
  • 资助金额:
    $ 63.51万
  • 项目类别:
Transplant Regimen Adherence for Kidney Recipients by Engaging Information Technologies: The TAKE IT Trial
通过利用信息技术提高肾受者的移植方案依从性:TAKE IT 试验
  • 批准号:
    9906214
  • 财政年份:
    2017
  • 资助金额:
    $ 63.51万
  • 项目类别:
A2ALL- Patient Safety System Improvements in Living Donor Liver Transplantation
A2ALL-活体肝移植中患者安全系统的改进
  • 批准号:
    8477034
  • 财政年份:
    2011
  • 资助金额:
    $ 63.51万
  • 项目类别:
A2ALL- Patient Safety System Improvements in Living Donor Liver Transplantation
A2ALL-活体肝移植中患者安全系统的改进
  • 批准号:
    8731865
  • 财政年份:
    2011
  • 资助金额:
    $ 63.51万
  • 项目类别:
A2ALL- Patient Safety System Improvements in Living Donor Liver Transplantation
A2ALL-活体肝移植中患者安全系统的改进
  • 批准号:
    8188248
  • 财政年份:
    2011
  • 资助金额:
    $ 63.51万
  • 项目类别:

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