Linking sensory uncertainty with motivation and memory

将感觉不确定性与动机和记忆联系起来

• 批准号: 10491711
• 负责人: Michael Cohanpour
• 金额: $ 4.68万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491711
• 关键词: Address; Affect; Animals; Anterior; Anxiety; Area; Attention; Automobile Driving; Behavior; Behavioral; Brain; Categories; Decision Making; Delayed Memory; Dorsal; Environment; Food; Functional Magnetic Resonance Imaging; Future; Goals; Hippocampus (Brain); Hour; Human; Image; Incentives; Influentials; Knowledge; Laboratories; Learning; Link; Literature; Measures; Mediating; Mediation; Memory; Methods; Midbrain structure; Modeling; Mood Disorders; Motivation; Neurons; Participant; Pathologic; Pathway interactions; Persons; Population; Prevalence; Proxy; Reporting; Rewards; Semantics; Sensory; Short-Term Memory; Signal Transduction; Source; Stimulus; Temporal Lobe; Testing; Therapeutic Intervention; Time; Training; Uncertainty; Visual; Visual system structure; Work; career; cingulate cortex; clinically relevant; cognitive function; cost; design; information processing; innovation; insight; intrinsic motivation; motivated behavior; neuromechanism; novel; response; sensory input; tool; visual information; visual memory

Abstract: Processing information that reduces uncertainty is a key role of the brain. Emerging evidence shows that, in addition to using information that is given to them, animals actively seek to obtain information about future rewards or semantic (trivia) questions. Information demand (ID) is robust even when it is non-instrumental (cannot be exploited to increase reward gains). Moreover, non-instrumental ID activates the reward-sensitive dopaminergic midbrain and enhances memory, suggesting that uncertainty, independently of reward gains, is a source of motivation for decision making and cognitive function. However, little is known about the neural mechanisms mediating these effects of uncertainty. I will address this question by designing a new task that measures perceptual ID and allows me to examine how signals of sensory uncertainty relate to those of motivation and memory. I identified visual images – “texforms” – that reliably activate human ventral temporal cortex (VTC) and can be distorted in a controlled fashion to parametrically manipulate the uncertainty about animate/ inanimate stimulus categories. Second, I will use a generative model to decode trial-by-trial sensory uncertainty from stimulus-evoked multi-voxel activity in the VTC. Finally, I show preliminary evidence that perceptual ID (the desire to reveal the identity of an ambiguous image) is related to behavioral reports of confidence (a proxy of uncertainty). In Aim 1, I will examine the hypothesis that sensory uncertainty in VTC relates to midbrain activity either directly or mediated by univariate responses to confidence (such as those in the dorsal anterior cingulate cortex). In Aim 2, I will examine the hypothesis that VTC uncertainty modulates the hippocampus and generates ID-related memory enhancements. Furthermore, I will explore the possibility that distinct network interactions mediate the effect of ID on immediate and delayed memory. Together, the findings will bring significant new insights into the pathways through which multivariate and univariate signals of uncertainty motivate actions that reduce uncertainty and affect memory. In addition, the results will expand our understanding of pathways that produce maladaptive effects of uncertainty in disorders of mood and anxiety.

抽象的： 处理减少不确定性的信息是大脑的关键作用。新出现的证据表明，在 除了使用提供给它们的信息外，动物还积极寻求获取有关未来的信息 奖励或语义（琐事）问题。即使是非工具性的信息需求（ID）也很强劲 （不能被用来增加奖励收益）。此外，非工具 ID 激活了奖励敏感的 多巴胺能中脑并增强记忆力，这表明独立于奖励增益的不确定性是一种 决策和认知功能的动机来源。然而，人们对神经元知之甚少 调节这些不确定性影响的机制。我将通过设计一个新任务来解决这个问题 测量感知 ID 并允许我检查感觉不确定性信号与那些感觉不确定性信号之间的关系 动机和记忆。我识别出视觉图像——“纹理”——能够可靠地激活人类腹侧颞叶 皮层（VTC），并且可以以受控方式扭曲，以参数化方式操纵不确定性 有生命/无生命的刺激类别。其次，我将使用生成模型来解码逐个试验的感官 VTC 中刺激引起的多体素活动的不确定性。最后，我展示初步证据 感知 ID（揭示模糊图像身份的愿望）与行为报告有关 信心（不确定性的代表）。在目标 1 中，我将检验 VTC 中感觉不确定性的假设 与中脑活动直接相关或由对信心的单变量反应介导（例如那些在 背侧前扣带皮层）。在目标 2 中，我将检验 VTC 不确定性调节的假设 海马体并产生与 ID 相关的记忆增强。此外，我将探讨以下可能性： 不同的网络交互介导了 ID 对即时记忆和延迟记忆的影响。综合起来，研究结果 将为多变量和单变量信号的途径带来重要的新见解 不确定性会激发减少不确定性并影响记忆的行动。此外，结果将扩大我们的 了解在情绪和焦虑障碍中产生不确定性的适应不良影响的途径。