Cellular and Molecular Oncology

细胞和分子肿瘤学

基本信息

批准号：
10491116
负责人：
Michelle A Ozbun
金额：
$ 11.94万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-26 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10491116
关键词：
Address Affect American Indians Animal Model Area Arsenic Automobile Driving Autophagocytosis Basic Science Behavior Behavioral Biochemical Biochemical Pathway Biochemical Process Bioinformatics Biology Biometry Cancer Center Support Grant Cancer Control Cancer Etiology Catchment Area Cell Communication Cell Culture System Cell model Cell physiology Cells Centers of Research Excellence Clinic Clinical Clinical Cancer Center Collaborations Communities Comprehensive Cancer Center Computer Models Development Direct Costs Doctor of Philosophy Environmental Carcinogens Environmental Exposure Environmental Pollution Epigenetic Process Exposure to Extramural Activities Flow Cytometry Funding Genetic Genetic study Genome Genome Stability Genomic approach Genomics Goals Grant Growth Human Imaging technology Immunology Incidence Indigenous American Inflammation Intervention Laboratories Malignant Neoplasms Mentors Metabolism Microscopy Modernization Molecular Molecular and Cellular Biology Mutation NCI Center for Cancer Research New Mexico Normal Cell Nuclear Pathway interactions Peer Review Pharmacy facility Phenotype Population Population Research Population Sciences Process Prognostic Marker Publications RNA Regulation Research Research Institute Research Personnel Resolution Resource Sharing Risk Factors Sampling Science Signal Pathway Signal Transduction Technology Therapeutic Therapeutic Human Experimentation Tissue imaging Tissues Tobacco use Training Training Programs Transcriptional Regulation Translating Translational Research Translations Ultraviolet Rays United States National Institutes of Health Universities Uranium Virus anticancer research cancer cell cancer genome cancer health disparity cancer initiation carcinogenesis carcinogenicity cellular imaging cellular oncology clinical translation college community setting diagnostic biomarker digital pathology environment related cancer fundamental research genome sequencing genome-wide high-throughput drug screening hispanic community imaging platform innovation interdisciplinary approach medical schools member microscopic imaging molecular oncology mortality novel oncology program patient engagement predictive modeling programs respiratory spatiotemporal synergism tumor initiation tumor microenvironment tumor progression working group

项目摘要

ABSTRACT: The Cellular and Molecular Oncology Research Program (CMO) is the fulcrum of basic mechanistic science in the University of New Mexico Comprehensive Cancer Center (UNMCCC). It facilitates inter-programmatic collaboration and translation to population research in the Cancer Control & Population Science Research (CCPS) Program and clinical-translational research in the Cancer Therapeutics Research (CT) Program to address cancers that are prevalent in New Mexico’s catchment area and the nation. Our overarching goals are to conduct outstanding cancer-relevant research in order to discover the cellular and molecular mechanisms that govern tumor initiation and drive cancer progression. These goals are accomplished through thematic research encompassing three scientific aims: (1) Carcinogenic Mechanisms of Environmental Exposures: To discover the molecular and cellular mechanisms by which environmental carcinogens and behavioral risk factors relevant to our catchment area promote cancer; (2) Genome Regulation: To define the mechanisms and pathways by which genome stability, epigenetic alterations, and transcriptional regulation are disrupted in cancer cells; and (3) Cellular Signaling and the Tumor Microenvironment: To determine how cell signaling pathways, cellular activities, and cell-cell interactions are altered during cancer initiation and progression and within the tumor microenvironment. The Program is led by Steven Belinsky, PhD, Mary Ann Osley, PhD, and Michelle Ozbun, PhD (incoming program co-leader as of 2020), who bring complementary expertise in the areas of molecular and cellular biology. The 37 Full Members and 4 Associate Members are drawn from 6 Basic Science and 4 Clinical Departments and Divisions in the UNM School of Medicine, and the UNM College of Pharmacy. The Program also takes advantage of the expertise of investigators in 2 UNM main campus departments, the Lovelace Respiratory Research Institute (LRRI) and Los Alamos National Laboratory, as well as state-of-the-art technologies provided by CCSG-supported Shared Resources. Annual direct cost funding as of 9/1/2020 equaled $8.7M ($2M from the NCI and $8M peer-reviewed). The discoveries made in this Program resulted in 352 publications, of which 38% were intra-programmatic collaborations and 26% were inter-programmatic collaborations, with a total collaborative publication level of 53%. Going forward, CMO will promote the growth of our new Program through expansion of program expertise and enhancement of program collaborations. CMO will continue to grow its expertise in discovery of the basic cellular and molecular mechanisms driving cancer, and build on its unique technological capabilities in advanced cell and tissue imaging, computer modeling, and state-of-the-art genomics to drive fundamental research in cancer etiology and progression and translate results to the clinic, our population and beyond.

摘要：细胞和分子肿瘤学研究计划（CMO）是基本的支点新墨西哥大学综合癌症中心（UNMCCC）的机械科学。它准备癌症控制和人群中的典型合作协作和转化为人群研究科学研究（CCPS）计划和癌症治疗研究中的临床翻译研究（CT）解决新墨西哥州集水区和国家普遍存在的癌症的计划。我们的总体目标是进行与癌症相关的出色研究，以发现细胞和控制肿瘤倡议并推动癌症进展的分子机制。这些目标是实现的通过主题研究，包括三个科学目的：（1）环境的致癌机制暴露：发现环境致癌物和细胞的分子和细胞机制与我们的集水区有关的行为风险因素促进癌症；（2）基因组调节：定义基因组稳定性，表观遗传学改变和转录调控的机制和途径是在癌细胞中破坏；（3）细胞信号传导和肿瘤微环境：确定细胞的方式在癌症开始期间，信号通路，细胞活性和细胞相互作用发生了变化，进展和肿瘤微环境内。该计划由史蒂文·贝林斯基（Steven Belinsky），博士学位，玛丽·安（Mary Ann）领导 Osley，PhD和Michelle Ozbun，博士学位（截至2020年，即将到来的计划联合领导者），他们带来完整分子和细胞生物学领域的专业知识。 37位完整成员和4个同学成员是来自UNM医学院的6个基础科学和4个临床部门和分裂 UNM药学院。该计划还利用了2个UNM主要的研究人员的专业知识校园部门，Lovelace呼吸研究所（LRRI）和Los Alamos国家实验室，以及由CCSG支持的共享资源提供的最新技术。年度直接成本截至9/1/2020的资金等于870万美元（来自NCI的200万美元和800万美元的同行评审）。发现的发现该计划产生了352个出版物，其中38％是截面的合作，26％是程序间合作，总协作出版物级别为53％。展望未来，CMO将通过扩展计划专业知识和计划的增强来促进我们的新计划的增长协作。 CMO将继续提高其在发现基本细胞和分子的发现方面的专业知识驱动癌症的机制，并以其高级细胞和组织中的独特技术能力为基础成像，计算机建模和最先进的基因组学，以推动癌症病因和进步并将结果转化为诊所，我们的人口及以后。