Career Enhancement Program

职业提升计划

• 批准号: 10493635
• 负责人: JONATHAN Alfred FLETCHER
• 金额: $ 9.2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493635
• 关键词: Achievement; Anatomy; Area; Basic Science; Behavior; Biological Markers; Biology; Biomedical Engineering; Biometry; Cancer Biology; Caring; Characteristics; Clinical; Clinical Investigator; Clinical Research; Committee Members; Dana-Farber Cancer Institute; Development; Diagnosis; Discipline; Disease; Disease model; Doctor of Philosophy; Ensure; Equilibrium; Faculty; Foundations; Funding; Funding Mechanisms; Genetic; Genetic Predisposition to Disease; Genomics; Genotype; Goals; In Vitro; Individual; Institution; Interdisciplinary Study; Investigational Therapies; Laboratories; Leadership; Learning; Life Expectancy; Medical; Medical Oncologist; Medical Oncology; Medicine; Mentors; Mentorship; Minority; Minority Women; Molecular; Nature; Operative Surgical Procedures; Pathologist; Pathology; Patients; Pediatric Oncology; Phenotype; Quality of life; Radiation; Radiation Oncologist; Radiation Oncology; Records; Research; Research Personnel; Research Support; Science; Scientist; Solid; Source; Specialist; Surgeon; Surgical Oncology; Talents; Time; Training; Translational Research; Universities; Uterine Leiomyosarcoma; Validation; Woman; cancer type; career; career development; design; experience; human capital; improved; in vitro Model; in vivo Model; innovation; insight; interdisciplinary approach; leiomyosarcoma; member; multidisciplinary; novel strategies; novel therapeutic intervention; pressure; programs; recruit; sarcoma; soft tissue; success; translational cancer research; translational scientist; translational study; tumor

Career Enhancement Program (CEP): Project Summary / Abstract By its very nature, leiomyosarcoma (LMS) demands a multi-disciplinary approach to care and research. LMS are highly aggressive tumors, which frequently present at high stage, and require the coordinated and integrated care of surgeons, radiation oncologists, and medical oncologists. In addition, the diverse nature of the anatomic sites of presentation, the differential behavior, and molecular characteristics of soft tissue and uterine LMS, and genotypic and phenotypic overlap with other pleomorphic sarcomas demands the involvement of anatomic and molecular pathologists. This SPORE will be uniquely poised to provide career development opportunities and mentorship for young investigators in all of these disciplines. In particular, the SPORE CEP will recruit and promote promising young researchers to pursue careers in translational studies of LMS or genetic predisposition for sarcoma/LMS. The SPORE mechanism will provide these CEP awardees with rich opportunities to interact with and learn from basic, translational, and clinical sarcoma researchers from key disciplines. Elizabeth G. Demicco MD, PhD (University of Toronto), and Jonathan A. Fletcher MD (Dana Farber Cancer Institute) will serve as co-directors for the SPORE CEP committee. The CEP committee will assist the co-directors in ensuring that the CEP meets its goals and that awardees are progressing in their career development and being adequately mentored. The committee represents the multi-disciplinary nature of translational sarcoma research, with particular expertise in sarcoma biology, target discovery and validations, genomics, experimental therapeutics, biostatistics, surgery, radiation medicine, biomarkers, and pathology. The committee members are academic leaders at the SPORE member institutions with experience in LMS. As seen across sarcoma-relevant medical and surgical disciplines, women and minorities continue to be underrepresented. It is a priority for this SPORE that diversity is enhanced in sarcoma research and we have endeavored to contribute to this effort by including women as members of all SPORE Committees and in the program leadership. Providing research support and protected time for young investigators is essential in translational research, particularly in sarcoma research, where funding mechanisms are few. The SPORE CEP will facilitate transition of awardees to independent investigator status and will prioritize funding early career scientists who seek to advance quality of life through research on disease mechanisms. Specific aims that assist the SPORE CEP in achieving these goals include: 1. Identifying and providing exceptional science and career mentorship to young sarcoma researchers; 2. Enforcing adequate protected time for clinically-oriented investigators to facilitate their development into independent translational researchers; 3. Recruiting highly qualified minority and women investigators from diverse clinical and scientific backgrounds into translational LMS research; and 4. Promoting multi-disciplinary research by encouraging young investigators to participate in scientific retreats.

职业提升计划 (CEP)：项目摘要/摘要 就其本质而言，平滑肌肉瘤 (LMS) 需要采用多学科方法进行护理和研究。学习管理系统是 高度侵袭性肿瘤，经常出现在晚期，需要协调和整合 外科医生、放射肿瘤科医生和肿瘤内科医生的护理。此外，解剖学的多样性 软组织和子宫 LMS 的表现部位、差异行为和分子特征，以及 与其他多形性肉瘤的基因型和表型重叠需要解剖学和 分子病理学家。这个 SPORE 将提供独特的职业发展机会和 为所有这些学科的年轻研究人员提供指导。特别是，SPORE CEP 将招募和 促进有前途的年轻研究人员从事 LMS 或遗传倾向的转化研究 用于肉瘤/LMS。 SPORE机制将为这些CEP获奖者提供丰富的互动机会 与来自关键学科的基础、转化和临床肉瘤研究人员一起学习。 Elizabeth G. Demicco MD、PhD（多伦多大学）和 Jonathan A. Fletcher MD（达纳·法伯 癌症研究所）将担任 SPORE CEP 委员会的联合主任。 CEP委员会将协助 联合董事确保 CEP 实现其目标并确保获奖者在职业生涯中取得进步 发展并得到充分的指导。该委员会代表了多学科性质 转化肉瘤研究，在肉瘤生物学、靶标发现和 验证、基因组学、实验疗法、生物统计学、外科手术、放射医学、 生物标志物和病理学。委员会成员均为SPORE会员学术带头人 具有 LMS 经验的机构。从肉瘤相关的医学和外科学科来看， 妇女和少数族裔的代表性仍然不足。多样性是这个 SPORE 的首要任务 肉瘤研究得到加强，我们努力通过包括女性在内的努力为这一努力做出贡献 作为所有 SPORE 委员会的成员并参与项目领导。 为年轻研究者提供研究支持和受保护的时间对于转化至关重要 研究，特别是肉瘤研究，其资助机制很少。 SPORE CEP 将促进 获奖者过渡到独立研究者身份，并将优先资助那些早期职业科学家 寻求通过疾病机制研究来提高生活质量。协助 SPORE 的具体目标 CEP 实现这些目标包括： 1. 确定并提供卓越的科学和职业指导 年轻的肉瘤研究人员； 2. 为临床研究人员提供足够的保护时间，以促进 他们发展成为独立的转化研究人员； 3. 招聘高素质的少数民族和女性 来自不同临床和科学背景的研究人员参与转化 LMS 研究； 4. 推广 通过鼓励年轻研究人员参加科学务虚会来进行多学科研究。