Career Enhancement Program

职业提升计划

• 批准号: 10493635
• 负责人: JONATHAN Alfred FLETCHER
• 金额: $ 9.2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493635
• 关键词: Achievement; Anatomy; Area; Basic Science; Behavior; Biological Markers; Biology; Biomedical Engineering; Biometry; Cancer Biology; Caring; Characteristics; Clinical; Clinical Investigator; Clinical Research; Committee Members; Dana-Farber Cancer Institute; Development; Diagnosis; Discipline; Disease; Disease model; Doctor of Philosophy; Ensure; Equilibrium; Faculty; Foundations; Funding; Funding Mechanisms; Genetic; Genetic Predisposition to Disease; Genomics; Genotype; Goals; In Vitro; Individual; Institution; Interdisciplinary Study; Investigational Therapies; Laboratories; Leadership; Learning; Life Expectancy; Medical; Medical Oncologist; Medical Oncology; Medicine; Mentors; Mentorship; Minority; Minority Women; Molecular; Nature; Operative Surgical Procedures; Pathologist; Pathology; Patients; Pediatric Oncology; Phenotype; Quality of life; Radiation; Radiation Oncologist; Radiation Oncology; Records; Research; Research Personnel; Research Support; Science; Scientist; Solid; Source; Specialist; Surgeon; Surgical Oncology; Talents; Time; Training; Translational Research; Universities; Uterine Leiomyosarcoma; Validation; Woman; cancer type; career; career development; design; experience; human capital; improved; in vitro Model; in vivo Model; innovation; insight; interdisciplinary approach; leiomyosarcoma; member; multidisciplinary; novel strategies; novel therapeutic intervention; pressure; programs; recruit; sarcoma; soft tissue; success; translational cancer research; translational scientist; translational study; tumor

Career Enhancement Program (CEP): Project Summary / Abstract By its very nature, leiomyosarcoma (LMS) demands a multi-disciplinary approach to care and research. LMS are highly aggressive tumors, which frequently present at high stage, and require the coordinated and integrated care of surgeons, radiation oncologists, and medical oncologists. In addition, the diverse nature of the anatomic sites of presentation, the differential behavior, and molecular characteristics of soft tissue and uterine LMS, and genotypic and phenotypic overlap with other pleomorphic sarcomas demands the involvement of anatomic and molecular pathologists. This SPORE will be uniquely poised to provide career development opportunities and mentorship for young investigators in all of these disciplines. In particular, the SPORE CEP will recruit and promote promising young researchers to pursue careers in translational studies of LMS or genetic predisposition for sarcoma/LMS. The SPORE mechanism will provide these CEP awardees with rich opportunities to interact with and learn from basic, translational, and clinical sarcoma researchers from key disciplines. Elizabeth G. Demicco MD, PhD (University of Toronto), and Jonathan A. Fletcher MD (Dana Farber Cancer Institute) will serve as co-directors for the SPORE CEP committee. The CEP committee will assist the co-directors in ensuring that the CEP meets its goals and that awardees are progressing in their career development and being adequately mentored. The committee represents the multi-disciplinary nature of translational sarcoma research, with particular expertise in sarcoma biology, target discovery and validations, genomics, experimental therapeutics, biostatistics, surgery, radiation medicine, biomarkers, and pathology. The committee members are academic leaders at the SPORE member institutions with experience in LMS. As seen across sarcoma-relevant medical and surgical disciplines, women and minorities continue to be underrepresented. It is a priority for this SPORE that diversity is enhanced in sarcoma research and we have endeavored to contribute to this effort by including women as members of all SPORE Committees and in the program leadership. Providing research support and protected time for young investigators is essential in translational research, particularly in sarcoma research, where funding mechanisms are few. The SPORE CEP will facilitate transition of awardees to independent investigator status and will prioritize funding early career scientists who seek to advance quality of life through research on disease mechanisms. Specific aims that assist the SPORE CEP in achieving these goals include: 1. Identifying and providing exceptional science and career mentorship to young sarcoma researchers; 2. Enforcing adequate protected time for clinically-oriented investigators to facilitate their development into independent translational researchers; 3. Recruiting highly qualified minority and women investigators from diverse clinical and scientific backgrounds into translational LMS research; and 4. Promoting multi-disciplinary research by encouraging young investigators to participate in scientific retreats.

职业提升计划（CEP）：项目摘要/摘要 就其本质而言，平滑肌肉瘤（LMS）需要多学科的方法来护理和研究。lm被 高度侵袭性肿瘤，经常出现在高阶段，需要协调和综合治疗。 外科医生、放射肿瘤学家和医学肿瘤学家的护理。此外，解剖学的多样性 软组织和子宫LMS的表现部位、差异行为和分子特征，以及 与其他多形性肉瘤的基因型和表型重叠需要解剖和 分子病理学家这个SPORE将提供独特的职业发展机会， 为所有这些学科的年轻研究人员提供指导。特别是，SPORE CEP将招募和 促进有前途的年轻研究人员从事LMS或遗传易感性的转化研究 肉瘤/LMS。SPORE机制将为这些CEP获奖者提供丰富的互动机会 与来自关键学科的基础，转化和临床肉瘤研究人员一起学习。 伊丽莎白·G. Demicco医学博士、哲学博士（多伦多大学）和Jonathan A.医学博士弗莱彻（达纳法伯 癌症研究所）将担任SPORE CEP委员会的联合主任。CEP委员会将协助 共同主任，以确保CEP实现其目标，并获奖者在他们的职业生涯中取得进展 发展和得到充分的指导。该委员会代表了多学科性质 转化肉瘤研究，特别是在肉瘤生物学，目标发现和 验证，基因组学，实验治疗学，生物统计学，外科学，放射医学， 生物标志物和病理学。委员会成员均为SPORE会员单位的学术带头人 有LMS经验的机构。正如在肉瘤相关的医学和外科学科中所看到的， 妇女和少数民族的代表性仍然不足。这是一个优先为这个孢子，多样性是 加强了肉瘤研究，我们有义务通过包括妇女在内的方式为这一努力做出贡献。 作为所有SPORE委员会的成员和项目领导。 为年轻的研究人员提供研究支持和受保护的时间在翻译中至关重要 研究，特别是肉瘤研究，那里的资金机制很少。SPORE CEP将促进 将获奖者转变为独立研究者，并优先资助那些 寻求通过研究疾病机制来提高生活质量。协助孢子的具体目标 CEP在实现这些目标方面包括：1.确定并提供卓越的科学和职业导师， 年轻的肉瘤研究者; 2.为面向临床的研究者提供足够的保护时间， 他们的发展成为独立的翻译研究者; 3。招聘高素质的少数民族和妇女 来自不同临床和科学背景的研究人员转化LMS研究;和4.促进 通过鼓励年轻的研究人员参加科学务虚会，开展多学科研究。