MOLECULAR CYTOGENETICS OF SOLID TUMORS

实体瘤的分子细胞遗传学

• 批准号: 2084049
• 负责人: JONATHAN Alfred FLETCHER
• 金额: $ 9.23万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2084049
• 关键词: DNA replication; basal cell carcinoma; cytogenetics; health science research; health science research support; neoplasm /cancer genetics

This physician-Scientist Award will enable Dr. Fletcher to acquire a broad and thorough training in the fields of experimental cytogenetics and molecular biology. In each phase of the award, these skills will be applied to specific research questions in the field of oncology. Phase I will be conducted under the co-sponsorship of Drs. Cynthia C. Morton and Philip Leder, in the Department of Pathology and Genetics, respectively, at Harvard Medial School. A primary focus of this phase will be to localize the causative gene for nevoid basal cell carcinoma syndrome. During Phase I, Dr. Fletcher will also participate in seminars and courses at Harvard Medical School and at the Jackson Laboratory, and will continue extensive work-in-progress on solid tumor cytogenetics. The solid tumor cytogenetics projects will include: 1) identification of characteristic chromosome rearrangements in specific malignancies; 2) investigation of the diagnostic significance of specific cytogenetic patterns in mesenchymal tumors; and 3) determination of the extent and role of genetic instability in adult malignancies. Dr. Samuel E. Lux, Chief of the Hematology-Oncology Division at The Children's Hospital, Boston, and Dr. STeven J. Burakoff, Chief, Division of Pediatric Oncology, Dana-Fraber Cancer Institute, will co-sponsor Phase II of this award. During Phase II, Dr. Fletcher will establish a laboratory devoted to the cytogenetic and molecular characterization of solid tumors at the Dana-Farber Cancer Institute. This laboratory will utilize cytogenetic findings as a basis for subsequent molecular investigations into the etiologies of solid tumors.

这个医学奖将使弗莱彻博士获得广泛的

项目成果

Extremely poor prognosis of pediatric acute lymphoblastic leukemia with translocation (9;22): updated experience.

伴有易位的儿童急性淋巴细胞白血病的预后极差 (9;22)：最新经验。

• DOI: 10.3109/10428199209049820
• 发表时间: 1992
• 期刊: Leukemia & lymphoma
• 影响因子: 2.6
• 作者: Fletcher,JA;Tu,N;Tantravahi,R;Sallan,SE
• 通讯作者: Sallan,SE

Codeletion of p15 and p16 genes in primary non-small cell lung carcinoma.

• DOI: 10.1016/0169-5002(96)84216-4
• 发表时间: 1995-07
• 期刊: Cancer research
• 影响因子: 11.2
• 作者: S. Xiao;D. Li;J. Corson;J. Vijg;J. Fletcher

Fluorescent in situ hybridization assessment of chromosome 7 copy number in uncultured lung and kidney cells.

未培养的肺和肾细胞中 7 号染色体拷贝数的荧光原位杂交评估。

• DOI: 10.1016/0165-4608(93)90235-e
• 发表时间: 1993
• 期刊: Cancer genetics and cytogenetics
• 作者: Naeem,R;Donovan,K;Corson,JM;Fletcher,JA
• 通讯作者: Fletcher,JA

Molecular characterization of a 17q11.2 translocation in a malignant schwannoma cell line.

恶性神经鞘瘤细胞系 17q11.2 易位的分子特征。

• DOI: 10.1007/bf00220476
• 发表时间: 1992
• 期刊: Human genetics
• 影响因子: 5.3
• 作者: Reynolds,JE;Fletcher,JA;Lytle,CH;Nie,L;Morton,CC;Diehl,SR
• 通讯作者: Diehl,SR

Identification of genetically aberrant cell lineages in Wilms' tumors.

肾母细胞瘤中遗传异常细胞谱系的鉴定。

• DOI: 10.1002/gcc.2870100107
• 发表时间: 1994
• 期刊: Genes, chromosomes & cancer
• 作者: Weremowicz,S;Kozakewich,HP;Haber,D;Park,S;Morton,CC;Fletcher,JA
• 通讯作者: Fletcher,JA