Boston Chronic Kidney Disease Research Biopsy Center

波士顿慢性肾脏病研究活检中心

基本信息

  • 批准号:
    10493645
  • 负责人:
  • 金额:
    $ 54.95万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-09-15 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Chronic kidney disease (CKD) affects 37 million Americans, costs tens of billions of dollars annually, and can lead to kidney failure, cardiovascular disease (CVD), and early mortality. CKD is not a single entity but rather a heterogeneous condition with a wide spectrum of underlying causes, pathologic and clinical manifestations, and varying rates of loss of kidney function. Because of the paucity of kidney biopsy samples from patients with common forms of CKD and the acknowledged limitations of animal models, our understanding of the pathology and molecular mechanisms of CKD is limited. Improved understanding of human CKD due to hypertension and diabetes will require investigation of kidney tissue from patients with CKD, using rapidly evolving techniques in molecular pathology. We are responding to RFA-DK-20-026 to continue as a multicenter CKD recruitment site for the Kidney Precision Medicine Project (KPMP) that builds upon the accomplishments of our established multidisciplinary research group in the UG3/UH3 phase. We propose to continue to participate as a successful CKD recruitment site in Boston, MA including four clinical sites: Joslin Diabetes Center, Beth Israel Deaconess Medical Center, Brigham and Women’s Hospital, and Boston Medical Center. The proposal builds upon an established infrastructure and our experience recruiting and retaining KPMP participants. In addition, our site has an outstanding safety record for participants with no major post-biopsy complications as well as exceeding the quality biospecimen metrics. For the U01 phase we propose to obtain repeat kidney biopsies in selected individuals as well as increase the focus on social determinants of health. We also will continue to biopsy individuals with longstanding Type 1 diabetes mellitus with no evidence of kidney pathology (‘resistors') to identify molecular underpinnings of protection against diabetic kidney disease. We are committed to continued collaborative protocol development, sharing best practices, and team science to achieve the KPMP’s objectives of advancing precision medicine to improve the lives of our patients with and at risk for CKD. The proposed research plan, by improving our understanding of CKD pathophysiology, has the potential to dramatically impact public health.
项目总结

项目成果

期刊论文数量(0)
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Sylvia E Rosas其他文献

Sylvia E Rosas的其他文献

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{{ truncateString('Sylvia E Rosas', 18)}}的其他基金

Boston Chronic Kidney Disease Research Biopsy Center
波士顿慢性肾脏病研究活检中心
  • 批准号:
    10704109
  • 财政年份:
    2022
  • 资助金额:
    $ 54.95万
  • 项目类别:
Harvard Chronic Kidney Disease Research Biopsy Center
哈佛慢性肾脏病研究活检中心
  • 批准号:
    10223910
  • 财政年份:
    2017
  • 资助金额:
    $ 54.95万
  • 项目类别:
Harvard Chronic Kidney Disease Research Biopsy Center
哈佛慢性肾脏病研究活检中心
  • 批准号:
    9910985
  • 财政年份:
    2017
  • 资助金额:
    $ 54.95万
  • 项目类别:
Kidney Transplant Outcomes and APOL1
肾移植结果和 APOL1
  • 批准号:
    9441559
  • 财政年份:
    2017
  • 资助金额:
    $ 54.95万
  • 项目类别:
9/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
9/14 APOL1 长期肾移植结果网络 (APOLLO) 临床中心
  • 批准号:
    10731303
  • 财政年份:
    2017
  • 资助金额:
    $ 54.95万
  • 项目类别:
Harvard Chronic Kidney Disease Research Biopsy Center
哈佛慢性肾脏病研究活检中心
  • 批准号:
    9394445
  • 财政年份:
    2017
  • 资助金额:
    $ 54.95万
  • 项目类别:
Kidney Transplant Outcomes and APOL1
肾移植结果和 APOL1
  • 批准号:
    9977155
  • 财政年份:
    2017
  • 资助金额:
    $ 54.95万
  • 项目类别:
Coronary calcification in hemodialysis patients
血液透析患者冠状动脉钙化
  • 批准号:
    7839055
  • 财政年份:
    2009
  • 资助金额:
    $ 54.95万
  • 项目类别:
Carotid Intima-Media Thickness in Chronic Kidney Disease: a CRIC ancillary study
慢性肾病中的颈动脉内膜中层厚度:CRIC 辅助研究
  • 批准号:
    7991408
  • 财政年份:
    2009
  • 资助金额:
    $ 54.95万
  • 项目类别:
Carotid Intima-Media Thickness in Chronic Kidney Disease: a CRIC ancillary study
慢性肾病中的颈动脉内膜中层厚度:CRIC 辅助研究
  • 批准号:
    8300240
  • 财政年份:
    2008
  • 资助金额:
    $ 54.95万
  • 项目类别:

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