Chemical Physiology Training Program

项目摘要 这个博士前“化学生理学培训”计划（CPT）的目标是招募和培养一个多样化的 培养应用化学生物学工具所需的技术和专业技能， 以安全、道德上负责和严格的方式将方法应用于整体动物和人体研究。学生 该计划将在化学生物学和生理学方面进行培训，并将学习如何以及何时建立 具有互补专业知识的研究团队。CPT计划的发展受到一些因素的促进， 改变现代化OHSU的研究生课程的结构和课程使用循证实践。 这些变化的总体目标是根据每一个学生的科学个性化研究生培养 和职业兴趣，允许在技术，操作和专业技能方面进行及时培训， 走向时间到度适当与每个毕业生的未来职业目标。该提案建立在 我们的生物医学科学计划（PBMS）和神经科学研究生课程（NGP）的成功， 利用最近在OHSU的许多部门的化学生物学和生理学的增长。 学生将被从PMCB和NGP研究生课程中拉出来。行政和指导 这些研究生课程的结构将保持不变，而新的中心结构将促进 学生和博士后在跨学科学习社区的成功交叉培训。我们 向NIGMS申请6个名额，用于资助3名毕业生第二年和第三年的学生 训练OHSU和Steinberg生理学培训基金会将每年资助额外的3个名额。 学生将在第一年完成学位授予计划和研究轮换所需的课程。 被任命为CPT的学生将被要求选择以下PBMS和NGP选修课：化学生物学 创新者，生理学原理，药物发现与开发（药代动力学），受体 药理学（药效学）和新课程化学与生理学的界面。学生将 在第一年参加其中的一些课程，然后在接受CPT后，他们将参加额外的 2年的课程。这些课程，连同课程解决定量分析和统计，严谨 和可重复性，以及负责任的研究行为提供了培训计划的学术核心。 他们补充了期刊俱乐部，研讨会和一系列专业发展课程， 活动学生将发展化学生物学和生理学的工作知识，并将发展 在一个学科有深厚的专业知识。学生将接受研究项目开发方面的培训和指导， 书面和口头沟通，并接触到一系列利用这些技能的工作机会。这位33 培训教师来自OHSU，代表多个部门，研究所和学校。我们的目标是 通过吸引和培养多样化的学生和教师群体来发展，并实施了几项 方法，以促进管道的发展，并接触到不同的学生群体。

Project Summary The goal of this predoctoral “Chemical Physiology Training” program (CPT) is to recruit and train a diverse pool of students to develop the technical and professional skills needed to apply chemical biology tools and methods to whole-animal and human studies in a safe, ethically responsible and rigorous manner. Students in this program will be trained in both chemical biology and in physiology and will learn how and when to build research teams with complementary expertise. Development of the CPT program is facilitated by a number of changes to modernize OHSU's graduate programs' structure and curriculum using evidence-based practices. The overall goals of these changes are to individualize graduate training according to each students scientific and career interests, allow for just-in-time training in technical, operational, and professional skills, and aim towards a time-to-degree appropriate with the future career goals of each graduate. This proposal builds on the success of our Program in Biomedical Sciences (PBMS) and Neuroscience Graduate Program (NGP) and takes advantage of the recent growth in Chemical Biology and Physiology across many departments at OHSU. Students will be pulled from both the PMCB and NGP graduate programs. The administrative and mentorship structures for those graduate programs will remain in place, while the new hub structure will facilitate successful cross training of students and post-docs in an interdisciplinary learning community. We are requesting 6 slots from NIGMS, which will be used to fund 3 students in years 2 and 3 of their graduate training. OHSU and the Steinberg endowment for training in Physiology will fund an additional 3 slots/year. Students will complete required coursework for their degree granting program and research rotations in year 1. Students appointed to CPT will be required to select the following PBMS and NGP electives: Chemical Biology Innovators, Principles of Physiology, Drug Discovery & Development (pharmacokinetics), Receptor Pharmacology (pharmacodynamics), and the new course Interface of Chemistry & Physiology. Students will take some of these courses during year 1 and then upon acceptance into CPT they will take the additional courses in year 2. These classes, together with courses addressing quantitative analysis and statistics, rigor and reproducibility, and the responsible conduct of research provide the academic core of the training program. They are supplemented with journal clubs, seminars, and a full array of professional development courses and activities. Students will develop a working knowledge of both chemical biology and physiology and will develop deep expertise in one discipline. Students will receive training and mentoring in research project development, written and verbal communication, and exposure to an array of job opportunities that utilize those skills. The 33 training faculty come from across OHSU, representing multiple departments, institutes, and schools. We aim to grow by attracting and fostering a diverse group of students and faculty, and have implemented several approaches to foster pipeline development and reach out to a diverse group of students.