Chemical Physiology Training Program

项目摘要 这一博士前“化学生理学培训”计划(CPT)的目标是招募和培养不同的 培养学生所需的技术和专业技能，以应用化学生物工具和 方法以安全、伦理负责和严格的方式进行全动物和人体研究。学生在 该计划将接受化学生物学和生理学方面的培训，并将学习如何以及何时建立 具有互补专业知识的研究团队。CPT方案的开发得到了一些 改变OHSU的研究生课程结构和课程，使用循证实践。 这些变化的总体目标是根据每个学生的科学情况进行个性化的研究生培养 和职业兴趣，允许在技术、操作和专业技能和目标方面进行及时培训 获得学位的时间与每个毕业生未来的职业目标相适应。这项建议建立在 我们在生物医学科学(PBMS)和神经科学研究生项目(NGP)方面的成功以及 利用OHSU多个系最近在化学生物学和生理学方面的增长。 学生将被从PMCB和NGP研究生项目中撤出。管理和指导 这些研究生课程的结构将保持不变，而新的中心结构将促进 在跨学科学习社区中成功地对学生和博士后进行交叉培训。我们是 从NIGMS申请6个名额，这些名额将用于资助3名研究生2年级和3年级 训练。OHSU和斯坦伯格生理学培训基金将为每年额外的3个名额提供资金。 学生将在第一年完成学位授予计划和研究轮换的必修课程。 被任命为CPT的学生将被要求选择下列PBM和NGP选修课：化学生物学 创新者，生理学原理，药物发现与开发(药代动力学)，受体 药理学(药效学)，以及化学与生理学的新课程接口。学生们将 在第一年选修这些课程中的一些，然后在被CPT录取后，他们将选修额外的 二年级的课程。这些课程，连同涉及定量分析和统计的课程，严谨 和重现性，以及负责任的研究行为，提供了培训计划的学术核心。 他们的补充是杂志俱乐部、研讨会和一系列的职业发展课程和 活动。学生将发展化学生物学和生理学的实用知识，并将发展 在一门学科上有深厚的专业知识。学生将接受研究项目开发方面的培训和指导， 书面和口头沟通，并接触到一系列利用这些技能的工作机会。33岁的 培训人员来自俄亥俄州立大学，代表多个部门、研究所和学校。我们的目标是 通过吸引和培养不同的学生和教师群体来实现增长，并实施了几个 促进渠道发展的方法，并接触不同的学生群体。

Project Summary The goal of this predoctoral “Chemical Physiology Training” program (CPT) is to recruit and train a diverse pool of students to develop the technical and professional skills needed to apply chemical biology tools and methods to whole-animal and human studies in a safe, ethically responsible and rigorous manner. Students in this program will be trained in both chemical biology and in physiology and will learn how and when to build research teams with complementary expertise. Development of the CPT program is facilitated by a number of changes to modernize OHSU's graduate programs' structure and curriculum using evidence-based practices. The overall goals of these changes are to individualize graduate training according to each students scientific and career interests, allow for just-in-time training in technical, operational, and professional skills, and aim towards a time-to-degree appropriate with the future career goals of each graduate. This proposal builds on the success of our Program in Biomedical Sciences (PBMS) and Neuroscience Graduate Program (NGP) and takes advantage of the recent growth in Chemical Biology and Physiology across many departments at OHSU. Students will be pulled from both the PMCB and NGP graduate programs. The administrative and mentorship structures for those graduate programs will remain in place, while the new hub structure will facilitate successful cross training of students and post-docs in an interdisciplinary learning community. We are requesting 6 slots from NIGMS, which will be used to fund 3 students in years 2 and 3 of their graduate training. OHSU and the Steinberg endowment for training in Physiology will fund an additional 3 slots/year. Students will complete required coursework for their degree granting program and research rotations in year 1. Students appointed to CPT will be required to select the following PBMS and NGP electives: Chemical Biology Innovators, Principles of Physiology, Drug Discovery & Development (pharmacokinetics), Receptor Pharmacology (pharmacodynamics), and the new course Interface of Chemistry & Physiology. Students will take some of these courses during year 1 and then upon acceptance into CPT they will take the additional courses in year 2. These classes, together with courses addressing quantitative analysis and statistics, rigor and reproducibility, and the responsible conduct of research provide the academic core of the training program. They are supplemented with journal clubs, seminars, and a full array of professional development courses and activities. Students will develop a working knowledge of both chemical biology and physiology and will develop deep expertise in one discipline. Students will receive training and mentoring in research project development, written and verbal communication, and exposure to an array of job opportunities that utilize those skills. The 33 training faculty come from across OHSU, representing multiple departments, institutes, and schools. We aim to grow by attracting and fostering a diverse group of students and faculty, and have implemented several approaches to foster pipeline development and reach out to a diverse group of students.