Chemical Physiology Training Program

项目概要 这个博士前“化学生理学培训”计划（CPT）的目标是招募和培训多样化的 培养学生应用化学生物学工具和所需的技术和专业技能 以安全、道德负责和严格的方式进行全动物和人类研究的方法。学生在 该计划将接受化学生物学和生理学方面的培训，并将学习如何以及何时构建 具有互补专业知识的研究团队。 CPT 计划的发展受到许多因素的促进 使用基于证据的实践来改变 OHSU 研究生课程结构和课程的现代化。 这些变化的总体目标是根据每个学生的科学情况对研究生进行个性化培训 和职业兴趣，允许及时进行技术、操作和专业技能培训，以及目标 争取与每个毕业生未来职业目标相适应的攻读学位的时间。该提案建立在 我们的生物医学科学项目 (PBMS) 和神经科学研究生项目 (NGP) 的成功以及 利用 OHSU 许多部门化学生物学和生理学的最新发展。 PMCB 和 NGP 研究生项目都将招收学生。行政和指导 这些研究生课程的结构将保持不变，而新的中心结构将促进 在跨学科学习社区中成功地对学生和博士后进行交叉培训。我们是 向 NIGMS 申请 6 个名额，用于资助 3 名学生的研究生第二年和第三年 培训。 OHSU 和 Steinberg 生理学培训捐赠基金将每年额外资助 3 个名额。 学生将在第一年完成学位授予计划和研究轮转所需的课程。 被指定参加 CPT 的学生将需要选择以下 PBMS 和 NGP 选修课：化学生物学 创新者、生理学原理、药物发现与开发（药代动力学）、受体 药理学（药效学），以及新课程化学与生理学界面。学生将 在第一年学习其中一些课程，然后在接受 CPT 后，他们将学习额外的课程 第二年的课程。这些课程，以及涉及定量分析和统计的课程，严谨 和可重复性以及负责任的研究行为构成了培训计划的学术核心。 它们还辅以期刊俱乐部、研讨会和全套专业发展课程， 活动。学生将发展化学生物学和生理学的应用知识，并发展 一门学科的深厚专业知识。学生将接受研究项目开发的培训和指导， 书面和口头沟通，以及接触一系列利用这些技能的工作机会。 33号 培训教师来自 OHSU 各个部门，代表多个院系、研究所和学校。我们的目标是 通过吸引和培养多元化的学生和教师群体来成长，并实施了多项 促进渠道发展并接触不同学生群体的方法。

Project Summary The goal of this predoctoral “Chemical Physiology Training” program (CPT) is to recruit and train a diverse pool of students to develop the technical and professional skills needed to apply chemical biology tools and methods to whole-animal and human studies in a safe, ethically responsible and rigorous manner. Students in this program will be trained in both chemical biology and in physiology and will learn how and when to build research teams with complementary expertise. Development of the CPT program is facilitated by a number of changes to modernize OHSU's graduate programs' structure and curriculum using evidence-based practices. The overall goals of these changes are to individualize graduate training according to each students scientific and career interests, allow for just-in-time training in technical, operational, and professional skills, and aim towards a time-to-degree appropriate with the future career goals of each graduate. This proposal builds on the success of our Program in Biomedical Sciences (PBMS) and Neuroscience Graduate Program (NGP) and takes advantage of the recent growth in Chemical Biology and Physiology across many departments at OHSU. Students will be pulled from both the PMCB and NGP graduate programs. The administrative and mentorship structures for those graduate programs will remain in place, while the new hub structure will facilitate successful cross training of students and post-docs in an interdisciplinary learning community. We are requesting 6 slots from NIGMS, which will be used to fund 3 students in years 2 and 3 of their graduate training. OHSU and the Steinberg endowment for training in Physiology will fund an additional 3 slots/year. Students will complete required coursework for their degree granting program and research rotations in year 1. Students appointed to CPT will be required to select the following PBMS and NGP electives: Chemical Biology Innovators, Principles of Physiology, Drug Discovery & Development (pharmacokinetics), Receptor Pharmacology (pharmacodynamics), and the new course Interface of Chemistry & Physiology. Students will take some of these courses during year 1 and then upon acceptance into CPT they will take the additional courses in year 2. These classes, together with courses addressing quantitative analysis and statistics, rigor and reproducibility, and the responsible conduct of research provide the academic core of the training program. They are supplemented with journal clubs, seminars, and a full array of professional development courses and activities. Students will develop a working knowledge of both chemical biology and physiology and will develop deep expertise in one discipline. Students will receive training and mentoring in research project development, written and verbal communication, and exposure to an array of job opportunities that utilize those skills. The 33 training faculty come from across OHSU, representing multiple departments, institutes, and schools. We aim to grow by attracting and fostering a diverse group of students and faculty, and have implemented several approaches to foster pipeline development and reach out to a diverse group of students.