Biospecimen Core

生物样本核心

• 批准号: 10492752
• 负责人: Carolyn Glass
• 金额: $ 51.15万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492752
• 关键词: Academic Medical Centers; Accreditation; Age; Ambulatory Care Facilities; Atlases; Autopsy; Biological; Biological Assay; Biological Markers; Biopsy; Blood specimen; Bronchoscopy; Cardiac Surgery procedures; Cell Aging; Cells; Childhood; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Collection; Colon; Communities; Consent; Consent Forms; Country; Coupled; Data; Diagnosis; Elderly; Endoscopy; Enrollment; Ensure; Epidemiology; Evaluation; Exposure to; Faculty; Fresh Tissue; Funding; Gastroenterology; Goals; Health; Heart; Heart Transplantation; Heterogeneity; Home; Hospitals; Individual; Infant; Informatics; Institution; International; Intervention; Investigation; Laboratories; Language; Liquid substance; Logistics; Longevity; Lung; Lung Transplantation; Maps; Measures; Mitotic; Modification; Molecular; Muscle; Normal tissue morphology; Operative Surgical Procedures; Organ; Organ Donor; Organ Transplantation; Participant; Pathologic; Pathologist; Pathology; Perinatal; Phase; Population; Practice Guidelines; Predisposition; Procedures; Process; Proliferating; Protocols documentation; Pulmonology; Quality Control; Race; Regulation; Research; Research Personnel; Research Support; Resource Sharing; Sampling; Schedule; Secure; Services; Skin; Socioeconomic Status; Somatic Mutation; Source; Specimen; Swab; Tissue Banks; Tissue Procurements; Tissues; Training; United States; Work; age group; base; biobank; body system; clinically relevant; cohort; data sharing; demographics; environmental stressor; fetal; gender diversity; human tissue; interest; middle age; peripheral blood; programs; prospective; quality assurance; real time monitoring; recruit; saliva sample; scale up; senescence; standard of care; stem cells; stool sample; tissue mapping; tissue resource; transplant centers

ABSTRACT – Biospecimen Core The Biospecimen Core is essential for the acquisition of all biospecimens, verification of “normal healthy tissue” diagnosis, processing and allocation of all tissue and associated biofluids/non-tissue specimens required for SCENT. Integration of multiple, well-established Duke institutions with highly specialized collaborative capabilities is a unique strength of this Core. We are a nationally recognized biorepository and one of the highest organ transplantations centers in the country. Biobanking activities occur in parallel with standard of care biopsies, scheduled surgical procedures, autopsies and organ donor procurements. The objective of this Core is to provide biospecimen services with exceptional quality control measures to enable tissue mapping of cellular senescence biomarkers in normal healthy tissues across the lifespan (fetal/perinatal to elderly). This Core will be led by a team with expertise in autopsy, organ donor and surgical tissue procurement. To accomplish our goals, we will work to 1) efficiently identify, procure and verify diagnoses of high-quality normal healthy tissue and concurrent biofluids/non-tissue specimens based on stringent criteria, 2) process high-quality normal healthy tissues for correlative analyses and 3) ensure quality assurance and quality controls for sample management, specimen tracking and biobanking informatics management for optimal banked tissue sharing for all SenNet funded institutions. Our long-term goal is to constantly evolve to meet the needs of our investigators, either through regulatory modifications, logistical modifications, additions to the service menu, or in creating solutions to challenging research problems.

摘要：生物标本芯