Core B: Clinical Resource Core

核心B：总结/摘要 临床资源核心（CRC;核心B）将为人类受试者提供支持， 密歇根大学（U-M）Udall中心通过招募，登记和详细的临床评估， 帕金森病（PD）受试者和年龄和性别匹配的对照（NC）受试者。的独特特征 拟议的U-M Udall中心将利用独特的深度临床和神经影像表型PD 人口从我们以前的尤德尔中心（09/2014-08/2020）。PD受试者队列全面 在上一个U-M Udall中心周期评估的学生将被招募进行额外的纵向评估， 新PD受试者的补充队列。CRC已将数据收集、录入和 验证，由生物统计和数据管理核心（BDMC;核心D）开发，符合 HIPAA和IRB法规。收集的数据与NINDS通用数据元素一致，以便于传输 使用ProFORMS将数据的数据库存储到NINDS数据管理库中。启联资源中心将与 神经影像资源核心（NRC;核心C），以协调受试者的体内神经影像评估。 CRC将作为项目III与荷兰帕金森研究者之间的联络人， 格罗宁根大学的认知（DUPARC）研究（P.I. Teus货车Laar博士）。CRC将继续 促进与太平洋尤德尔中心（P.I.托马斯·蒙廷博士）和 罗切斯特尤德尔中心（P.I.雷多尔西博士）。《儿童权利公约》的具体目标是： 1.招募、入组和保留PD受试者（净入组目标为N=100例合格PD受试者）， U-M Udall中心项目I和III的性别匹配的NC受试者（N=20），以支持他们的科学研究。 目标. 2.全面评估所有具有良好临床、运动功能和 在基线和随访时使用神经心理学仪器。 3.为U-M Udall中心项目I和III提供组织结构和运营监督 并与其他核心进行互动和协调，以确保及时的神经影像评估（NRC）和数据 传输和分析（BDMC）。 4.促进和协调格罗宁根大学DUPARC研究的数据传输。 5.支持与其他Udall中心的现有合作，并促进这些Udall中心之间的数据传输 中心

CORE B: SUMMARY/ABSTRACT The Clinical Resource Core (CRC; Core B) will provide support for human subjects Projects I and III of the University of Michigan (U-M) Udall Center through recruitment, enrollment, and detailed clinical assessment of Parkinson disease (PD) subjects and age- and gender-matched control (NC) subjects. A unique feature of the proposed U-M Udall Center is that it will leverage the unique deeply clinical and neuroimaging phenotyped PD population from our previous Udall Center (09/2014-08/2020). The cohort of PD subjects comprehensively assessed in the previous U-M Udall Center cycle will be recruited for additional longitudinal assessments with a supplemental cohort of new PD subjects. The CRC has standardized methods for data collection, entry, and verification, as developed by the Biostatistics and Data Management Core (BDMC; Core D), compliant with HIPAA and IRB regulations. Data collected is consistent with NINDS Common Data Elements to facilitate transfer of data to the NINDS Data Management Repository using ProFORMS. The CRC will closely collaborate with the Neuroimaging Resource Core (NRC; Core C) to coordinate in vivo neuroimaging assessments of subjects. The CRC will serve as the liaison between Project III and the investigators of the Dutch Parkinson and Cognition (DUPARC) study at the University of Groningen (P.I. Dr. Teus van Laar). The CRC will continue to foster existing collaborations with the Pacific Udall Center (P.I. Dr. Thomas Montine) and the University of Rochester Udall Center (P.I. Dr. Ray Dorsey). The specific goals of the CRC are: 1. To recruit, enroll, and retain PD subjects (net enrollment target of N=100 eligible PD subjects) and age- and gender-matched NC subjects (N=20) for the U-M Udall Center Projects I and III in support of their scientific goals. 2. To comprehensively assess all subjects with well-established clinical, motor function, and neuropsychological instruments at baseline and follow-up. 3. To provide the organizational structure and operations oversight for the U-M Udall Center Projects I and III and interact and coordinate with other Cores to assure prompt neuroimaging assessment (NRC) and data transfer and analysis (BDMC). 4. Facilitate and coordinate data transfer from the University of Groningen DUPARC study. 5. Support existing collaborations with other Udall Centers and facilitate transfer of data to and from these Udall Centers